- Principles and Biological Pathways to Tissue Regeneration: The Tissue Regenerative Niche

Growth factors, medicine and synthetic peptides

Impact ◽

10.21820/23987073.2018.3.19 ◽

2018 ◽

Vol 2018 (3) ◽

pp. 19-21

Author(s):

Kunio Matsumoto

Keyword(s):

Drug Discovery ◽

Tissue Regeneration ◽

Synthetic Peptides ◽

Tumour Growth ◽

Biological Pathways ◽

Dynamic Movement ◽

Cord Injury ◽

Two Sides ◽

Hepatocyte Growth ◽

Lateral Sclerosis

Biological pathways often have an important role in more than one process. Equally, processes that are essential for normal physiology are hijacked by diseases such as cancer. The same pathways that assist tumour growth, survival and spreading can be critically important for the recovery from injuries or other diseases. This means there are often two sides to consider in the research of these pathways. Hepatocyte growth factor (HGF) is a protein that has intrinsically a key role in pathways responsible for dynamic movement, reconstruction and survival of cells for tissue regeneration. In tumour tissues, however, these actions of HGF participate in tumour spreading, metastasis and resistance against anticancer drugs. At the forefront of Matsumoto's research is the potential targeting of HGF and its receptor MET in regeneration and cancer, leading to drug discovery. He started bioventure to facilitate his research to clinical application. Clinical trials of HGF protein for treatment of amyotrophic lateral sclerosis/ALS and spinal cord injury are ongoing. He recently discovered artificial HGF composed of synthetic peptides. The artificial HGF can be the next generation biological drug by chemical synthesis. Peptides targeting HGF-MET pathway will be invaluable in the drug discovery for diagnosis and therapeutics of cancer.

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Are Grapes Able to Mitigate the Noxious Effects Induced by Cadmium Exposure in Different Tissues and/or Organs? A Mini Review

Drug Research ◽

10.1055/s-0044-101255 ◽

2018 ◽

Vol 69 (03) ◽

pp. 125-129

Author(s):

Bianca Handan ◽

Caroline Cardoso ◽

Luciana Pisani ◽

Debora Estadella ◽

Rosângela Chriguer ◽

...

Keyword(s):

Tissue Regeneration ◽

Health Professionals ◽

Scientific Literature ◽

Biological Pathways ◽

Cadmium Exposure ◽

Essential Metal ◽

Health Promoting ◽

Living Organisms ◽

Dark Blue ◽

Different Tissues

AbstractGrapes are fruits that grow in clusters and can be crimson, black, dark blue, yellow, green, orange, and pink. Cadmium is a non-essential metal toxic to living organisms and the environment. Recently, health professionals, food scientists, and consumers have paid much attention to grapes for their health-promoting effects. To the best of our knowledge, there are no reviews describing the ability of grapes to mitigate the toxic effects induced by cadmium exposure in different tissues and/or organs. Herein, the aim of this review is to present the effects of grapes following cadmium exposure on the number of papers published in the scientific literature. The results showed that grapes are able to mitigate the harmful activities induced by exposure to cadmium in several tissues and organs. The main actions are closely related to tissue regeneration as a result of the reestablishment of morphology and antioxidant activity. However, further studies are welcomed in order to elucidate new biological pathways regarding the outcomes promoted by grapes in this context, specially related to inflammation, tissue regeneration and cellular death.

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Decellularized bone extracellular matrix in skeletal tissue engineering

Biochemical Society Transactions ◽

10.1042/bst20190079 ◽

2020 ◽

Vol 48 (3) ◽

pp. 755-764

Author(s):

Benjamin B. Rothrauff ◽

Rocky S. Tuan

Keyword(s):

Tissue Engineering ◽

Bone Regeneration ◽

Tissue Regeneration ◽

Animal Studies ◽

Tumor Resection ◽

Regenerative Capacity ◽

Skeletal Tissue ◽

Large Bone

Bone possesses an intrinsic regenerative capacity, which can be compromised by aging, disease, trauma, and iatrogenesis (e.g. tumor resection, pharmacological). At present, autografts and allografts are the principal biological treatments available to replace large bone segments, but both entail several limitations that reduce wider use and consistent success. The use of decellularized extracellular matrices (ECM), often derived from xenogeneic sources, has been shown to favorably influence the immune response to injury and promote site-appropriate tissue regeneration. Decellularized bone ECM (dbECM), utilized in several forms — whole organ, particles, hydrogels — has shown promise in both in vitro and in vivo animal studies to promote osteogenic differentiation of stem/progenitor cells and enhance bone regeneration. However, dbECM has yet to be investigated in clinical studies, which are needed to determine the relative efficacy of this emerging biomaterial as compared with established treatments. This mini-review highlights the recent exploration of dbECM as a biomaterial for skeletal tissue engineering and considers modifications on its future use to more consistently promote bone regeneration.

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