Theory of Thin Layer Chromatography in Context of Pharmaceutical Analysis

2013 ◽  
pp. 1-2
Keyword(s):  
Thin Layer ◽  
Thin Layer Chromatography ◽  
Pharmaceutical Analysis ◽  
Layer Chromatography

Recent Applications of High Performance Thin Layer Chromatography and Derivative Spectrophotometry in Pharmaceutical Analysis

2020 ◽  
Vol 16 (6) ◽  
pp. 671-689
Author(s):  
Marcin Gackowski ◽  
Marcin Koba ◽  
Katarzyna Mądra-Gackowska ◽  
Piotr Kośliński ◽  
Stefan Kruszewski
Keyword(s):  
Thin Layer ◽  
Thin Layer Chromatography ◽  
Pharmaceutical Analysis ◽  
High Performance ◽  
Degradation Products ◽  
Derivative Spectrophotometry ◽  
Accuracy And Precision ◽  
Post Marketing ◽  
Layer Chromatography

At present, no one can imagine drug development, marketing and post-marketing without rigorous quality control at each stage. Only modern, selective, accurate and precise analytical methods for determination of active compounds, their degradation products and stability studies are able to assure the appropriate amount and purity of drugs administered every day to millions of patients all over the world. For routine control of drugs simple, economic, rapid and reliable methods are desirable. The major focus of current scrutiny is placed on high-performance thin layer chromatography and derivative spectrophotometry methods, which fulfill routine drug estimation’s expectations [1-4]. The present paper reveals state-of-the-art and possible applications of those methods in pharmaceutical analysis between 2010 and 2018. The review shows advantages of high-performance thin layer chromatography and derivative spectrophotometry, including accuracy and precision comparable to more expensive and time-consuming methods as well as additional fields of possible applications, which contribute to resolving many analytical problems in everyday laboratory practice.

Sorbents for thin-layer chromatography in pharmaceutical analysis

2010 ◽  
Vol 44 (9) ◽  
pp. 521-524 ◽  
Author(s):  
O. A. Goroshko ◽  
O. A. Checha ◽  
V. P. Pakhomov ◽  
Yu. V. Ruvinov ◽  
T. D. Ismagilov
Keyword(s):  
Thin Layer ◽  
Thin Layer Chromatography ◽  
Pharmaceutical Analysis ◽  
Layer Chromatography

scholarly journals Teaching the Basics of Pharmaceutical Analysis by Thin-Layer Chromatography and High-Performance Thin-Layer Chromatography to Undergraduate Students—Laboratory Practicals

1999 ◽  
Vol 82 (1) ◽  
pp. 38-47
Author(s):  
Jukka-Pekka Salo ◽  
Hannele Salomies
Keyword(s):  
Thin Layer ◽  
Thin Layer Chromatography ◽  
Undergraduate Students ◽  
Pharmaceutical Analysis ◽  
High Performance ◽  
Real Life ◽  
Point Of View ◽  
Pharmacy Students ◽  
Layer Chromatography ◽  
Complete Solutions

Abstract As part of the renewal of the pharmacy students’ curriculum, we planned a 2-day program with 9 exercises in thin-layer chromatography to teach the basics of the technique. Written reports with proper presentation ofresults were required. Related issues such assimple experimental design were integrated into the program. The results and difficultiesin their interpretation are described from a teacher’s point of view. As in real life, some exercises do not allow simple conclusions or complete solutions to a problem. The mostly positive feedback about the program suggests the program served its purpose well.

Thin-Layer Chromatography

1965 ◽  
Author(s):  
H. R. Bolliger ◽  
M. Brenner ◽  
H. Gänshirt ◽  
Helmut K. Mangold ◽  
H. Seiler ◽  
...  
Keyword(s):  
Thin Layer ◽  
Thin Layer Chromatography ◽  
Layer Chromatography

THE LESS-POLAR METABOLITES PRODUCED BY INCUBATION OF TESTOSTERONE-4-14C WITH RAT AND BOVINE BRAIN

1969 ◽  
Vol 61 (4) ◽  
pp. 641-648 ◽  
Author(s):  
Leon J. Sholiton ◽  
Emile E. Werk
Keyword(s):  
Thin Layer ◽  
Thin Layer Chromatography ◽  
Paper Chromatography ◽  
Specific Activity ◽  
Bovine Brain ◽  
Polar Fraction ◽  
End Products ◽  
Polar Metabolites ◽  
Layer Chromatography ◽  
Constant Specific Activity

ABSTRACT Rat and bovine brain have been incubated with testosterone-4-14C under standard conditions. With use of paper chromatography, the extracted metabolites were noted to fall into less-polar, iso-polar, and more polar fractions. The components of the less-polar fraction were separated by acetylation and thin-layer chromatography and the major end-products identified by recrystallization to constant specific activity or constant 3H/14C ratios. Androst-4-enedione and 5α-dihydrotestosterone were formed consistently under the conditions utilized. Trace amounts of other less-polar metabolites were noted occasionally.

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