Chitin and Chitosan Derivatives for Wound-Healing Applications

2013 ◽  
pp. 259-274
2021 ◽  
Vol 12 (3) ◽  
pp. 035016
Author(s):  
Natalya Nikolaevna Glushchenko ◽  
Olga Alexandrovna Bogoslovskaya ◽  
Balzhima Tsyrendorzhievna Shagdarova ◽  
Alla Victorovna Il’ina ◽  
Irina Pavlovna Olkhovskaya ◽  
...  

1984 ◽  
Vol 62 (5) ◽  
pp. 975-980 ◽  
Author(s):  
Manssur Yalpani ◽  
Laurance D. Hall

Nitroxide spin labels have been attached to chitin, chitosan, and their derivatives in order to investigate the solution and gel characteristics of these polymers. Thus, chitin was nonselectively acylated using the chloroacetamide label 3 to afford. the corresponding nitroxide derivative 4. Selective and nonselective labelling of chitosan was accomplished either via reductive alkylation using the keto label 5 and sodium cyanoborohydride or via a chitosan sulfate intermediate using labels 3 or 5. Two branched water soluble chitosan derivatives, carrying C-6 oxidized, terminal galactose side chains were selectively labelled by reductive animation using the amine label 13 to yield derivatives 14 and 15. Motional correlation values of the covalently-linked nitroxide moieties were shown to reflect the nature of the linkage between spin label and polymer, as well as structural differences between the branch residues of derivatives 14 and 15. The spin-probe – spin-label method was employed to demonstrate structural heterogeneities for the chitosan derivatives 7 and 15.


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