Brain Serotonergic Receptors and Control of Fluid Intake and Cardiovascular Function in Rats

2013 ◽  
pp. 183-212
1998 ◽  
Vol 8 (2) ◽  
pp. 175-295 ◽  
Author(s):  
Craig A. Horswill

As a result of exercise-induced sweating, athletes and trained individuals can lose up to 3 L of fluid per hour. Fluid replacement is required to maintain hydration and allow the athlete to continue to perform. Inadequate fluid intake will adversely affect temperature regulation, cardiovascular function, and muscle metabolism. To maximize fluid intake and effectively replace fluid, athletes must employ behavioral strategies. Athletes can also select beverages with characteristics that complement their behavioral efforts. Palatability, rapid absorption, retention of the fluid, and ergogenicity are the major attributes to consider for enhancing hydration during training and physical activity.


2016 ◽  
Vol 2 (1) ◽  
pp. 22
Author(s):  
Wayunah Wayunah ◽  
Muhammad Saefulloh ◽  
Wiwin Nuraeni

ABSTRAK Jumlah kasus chronic kidney disease yang harus menjalani terapi hemodialisa sejumlah 400 pasien dari 1.000.000 penduduk di Indonesia (Situmorang, 2013). Pemantauan keberhasilan hemodialisa diukur dari Inter Dialilytic Weight Gain (IDWG) yang tidak lebih dari 4 % berat kering. Nilai IDWG yang melebihi dari normal menimbulkan gejala edema, sesak nafas, dan rasa tidak nyaman. Salah satu kepatuhan pasien dalam mempertahankan IDWG adalah self efficacy. Penelitian ini bertujuan untuk menganalisa pengaruh edukasi terstruktur terhadap self efficacy dan IDWG pada pasien hemodialisa. Desain penelitian quasi experimen, dengan pendekatan pretest-posttest with control group. Pemilihan sampel menggunakan purposive sampling. Jumlah sampel 38 pasien hemodialisa dibagi dua kelompok 22 kelompok intervensi dan 16 kelompok kontrol. Edukasi diberikan dengan gambar dan video dalam media LCD proyektor dan leaflet. IDWG diukur dengan observasi berat badan sedangkan self efficacy menggunakan kuesioner. Uji statistik menggunakan uji t-dependen dan t-independen. Hasil penelitian menunjukkan pemberian edukasi terstruktur pada kelompok intervensi meningkatkan self efficaccy untuk mengontrol intake cairan antar waktu dialysis (p=0,000, α=0,05), dan menurunkan IDWG (p=0,04, α=0,05). Sedangkan pada kelompok kontrol penerapan edukasi meningkatkan self efficacy (p=0,03, α=0,05), namun tidak menurnkan IDWG (p=0,053, α=0,05). Hasil analisis lanjut menggunakan uji t-independen pada kedua kelompok ditemukan tidak ada perbedaan yang bermakna dalam self efficacy dan IDWG (p > 0,05). Edukasi terstruktur berpengaruh dalam meningkatkan self efficacy dan menurunkan IDWG. Kata kunci : self efficacy, IDWG, edukasi terstruktur ABSTRACT The number of chronic kidney disease with hemodialysis therapy was 400 patients of 1,000,000 population in Indonesia (Situmorang, 2013). The success hemodialysis was monitored by Inter Dialilytic Weight Gain (IDWG) and the criteria was not more than 4 % of dry weight. An excess of IDWG value would cause the symptoms of edema, shortness of breath, and discomfort. Self efficacy was one of patient compliance in maintaining IDWG. The aim of this study was to analyze the effect of a structured education on self-efficacy and IDWG in hemodialysis patients. The study used quasi experimental design, with pretest-posttest control group approach. The sample was selected by purposive sampling technique. The sample was 38 patients, divided into intervention group (22 patients) and control group (16 patients). The intervention of structured education was use pictures and videos by LCD projector and leaflets. IDWG was measured by weight observation, while self-efficacy by questionnaire. The statistical test used t-dependent and t-independent. The result showed that structured education increased self efficaccy to control fluid intake on inter dialysis time (p = 0.000, α = 0.05) and decreased IDWG value (p = 0.04, α = 0.05) in the intervention group. While the intervention increased self efficaccy to control fluid intake on inter dialysis  time (p = 0.03, α = 0.05) and decreased IDWG value (p=0,053, α=0,05) in the control group. The results of further analysis used an independent t-test, showed that there were not a significant differences in self-efficacy and IDWG (p> 0.05) between intervention and control group. The structured education caused an increasing of self-efficacy and a decreasing of IDWG value. Keyword : self efficacy, IDWG, structured education


1995 ◽  
Vol 78 (4) ◽  
pp. 1219-1224 ◽  
Author(s):  
D. E. Dluzen ◽  
B. Liu ◽  
C. Y. Chen ◽  
S. E. DiCarlo

Behavioral and neurochemical indexes of nigrostriatal dopaminergic function were compared between sedentary control rats (n = 12) and daily spontaneous running (DSR) male rats (n = 10). Nine weeks of DSR did not significantly alter body, heart, pituitary, or testes weights. DSR and control animals did differ in performance on a sensorimotor beam walking task, with DSR rats showing significantly shorter times required to cross the beam (60 +/- 17 vs. 119 +/- 14s; P < 0.02) as well as fewer slips off the beam (3.0 +/- 0.8 vs 6.2 +/- 1.1; P < 0.05). DSR animals also engaged in significantly greater durations of social investigation than control rats (43 +/- 5 vs 25 +/- 3 s; P < 0.01) when tested in a social investigation memory-recognition test. Basal dopamine release rates from superfused corpus striatal tissue fragments of DSR rats were about one-half those obtained from control animals (18 +/- 5 vs. 34 +/- 6 pg.mg-1.min-1; P < 0.05), whereas responses of these striatal tissue fragments to a depolarizing concentration of potassium were virtually identical (45 +/- 10 vs. 47 +/- 8 pg.mg-1.min-1). These data indicate that a relatively limited intensity of DSR insufficient to alter cardiovascular function can exert substantial effects on behavioral and neurochemical indicators of nigrostriatal dopaminergic activity.


2020 ◽  
Author(s):  
Zoë A. Marshall ◽  
Kelly A. Mackintosh ◽  
Michael J. Lewis ◽  
Elizabeth A. Ellins ◽  
Melitta A. McNarry

2018 ◽  
Vol 20 (1) ◽  
pp. 27-33
Author(s):  
Maulida Ulfah ◽  
Yuniarti Yuniarti ◽  
Arintina Rahayuni

Background:Between 8 to 10% of the adult population suffers kidney damage and every year millions of people die from complications related to CKD. Fluidintake restrictions is the most difficult aspect to adhere, in RSUD Sukoharjo 45,16% who do not adherence of fluid intake restrictions. Based on the results of research in RSUD Sukoharjo as much as 58,06% patients have less knowledge of fluid intake restrictions.Objective: Know the effects of nutrition counseling to knowledge and adherence of fluid intake restrictions on CKD patients in RSUD Abdul Wahab Sjahranie Samarinda.Methods:The type of research was quasi experiment, using pre-post test control group design. Total research subjects were 15 people treatment and 15 control people. Data analysis used to know the difference using different test.Results:There was a significant difference in knowledge of fluid intake restrictionsbefore and after nutritional counseling using leaflets p <0,05 (p = 0,001). There was a significant difference in adherence of fluid intake restrictionsbefore and after nutritional counseling using leaflets p <0,001 (p=0,000). There was a significant difference in knowledge of fluid intakerestrictions before and after nutrition counseling between treatment group and control group p <0,05 (p = 0,006). There was no significant difference in adherence of  fluid intakerestrictions before and after nutrition counseling between treatment group and control group p> 0,05 (p = 0,109).Conclusion:Nutrition counseling can improve the knowledge and adherence of fluid intake restrictions in CKD patients undergoing Hemodialysis significantly


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