Polymeric Nanoparticles from Pure Block Copolymers

2013 ◽  
pp. 67-218
Keyword(s):  
Block Copolymers ◽  
Polymeric Nanoparticles ◽  
Pure Block

Solvent Effects on the Synthesis of Polymeric Nanoparticles via Block Copolymer Self-Assembly Using Microporous Membranes

2020 ◽  
Vol 1000 ◽  
pp. 324-330
Author(s):  
Sri Agustina ◽  
Masayoshi Tokuda ◽  
Hideto Minami ◽  
Cyrille Boyer ◽  
Per B. Zetterlund
Keyword(s):  
Block Copolymer ◽  
Block Copolymers ◽  
Self Assembly ◽  
Polymeric Nanoparticles ◽  
Raft Polymerization ◽  
Membrane Emulsification ◽  
Membrane Pore ◽  
Novel Technique ◽  
Wide Range ◽  
Membrane Pore Size

The self-assembly of block copolymers has attracted attention for many decades because it can yield polymeric nanoobjects with a wide range of morphologies. Membrane emulsification is a fairly novel technique for preparation of various types of emulsions, which relies on the dispersed phase passing through a membrane in order to effect droplet formation. In this study, we have prepared polymeric nanoparticles of different morphologies using self-assembly of asymmetric block copolymers in connection with membrane emulsification. Shirasu Porous Glass (SPG) membranes has been employed as the membrane emulsification equipment, and poly (oligoethylene glycol acrylate)-block-poly (styrene) (POEGA-b-PSt) copolymers prepared via RAFT polymerization. It has been found that a number of different morphologies can be achieved using this novel technique, including spheres, rods, and vesicles. Interestingly, the results have shown that the morphology can be controlled not only by adjusting experimental parameters specific to the membrane emulsification step such as membrane pore size and pressure, but also by changing the nature of organic solvent. As such, this method provides a novel route to these interesting nanoobjects, with interesting prospects in terms of exercising morphology control without altering the nature of the block copolymer itself.

scholarly journals Paclitaxel Magnetic Core–Shell Nanoparticles Based on Poly(lactic acid) Semitelechelic Novel Block Copolymers for Combined Hyperthermia and Chemotherapy Treatment of Cancer

Pharmaceutics ◽  
2019 ◽  
Vol 11 (5) ◽  
pp. 213 ◽  
Author(s):  
Evi Christodoulou ◽  
Maria Nerantzaki ◽  
Stavroula Nanaki ◽  
Panagiotis Barmpalexis ◽  
Kleoniki Giannousi ◽  
...  
Keyword(s):  
Electron Microscopy ◽  
Lactic Acid ◽  
Block Copolymers ◽  
Polymeric Nanoparticles ◽  
Average Particle Size ◽  
In Vitro Release ◽  
Poly Lactic Acid ◽  
Average Particle ◽  
Chemotherapy Treatment ◽  
Cytotoxicity Studies

Magnetic hybrid inorganic/organic nanocarriers are promising alternatives for targeted cancer treatment. The present study evaluates the preparation of manganese ferrite magnetic nanoparticles (MnFe2O4 MNPs) encapsulated within Paclitaxel (PTX) loaded thioether-containing ω-hydroxyacid-co-poly(d,l-lactic acid) (TEHA-co-PDLLA) polymeric nanoparticles, for the combined hyperthermia and chemotherapy treatment of cancer. Initially, TEHA-co-PDLLA semitelechelic block copolymers were synthesized and characterized by 1H-NMR, FTIR, DSC, and XRD. FTIR analysis showed the formation of an ester bond between the two compounds, while DSC and XRD analysis showed that the prepared copolymers were amorphous. MnFe2O4 MNPs of relatively small crystallite size (12 nm) and moderate saturation magnetization (64 emu·g−1) were solvothermally synthesized in the sole presence of octadecylamine (ODA). PTX was amorphously dispersed within the polymeric matrix using emulsification/solvent evaporation method. Scanning electron microscopy along with energy-dispersive X-ray spectroscopy and transmission electron microscopy showed that the MnFe2O4 nanoparticles were effectively encapsulated within the drug-loaded polymeric nanoparticles. Dynamic light scattering measurements showed that the prepared nanoparticles had an average particle size of less than 160 nm with satisfactory yield and encapsulation efficiency. Diphasic PTX in vitro release over 18 days was observed while PTX dissolution rate was mainly controlled by the TEHA content. Finally, hyperthermia measurements and cytotoxicity studies were performed to evaluate the magnetic response, as well as the anticancer activity and the biocompatibility of the prepared nanocarriers.

scholarly journals Photothermal and photodynamic activity of polymeric nanoparticles based on α-tocopheryl succinate-RAFT block copolymers conjugated to IR-780

2017 ◽  
Vol 57 ◽  
pp. 70-84 ◽  
Author(s):  
Raquel Palao-Suay ◽  
Francisco M. Martín-Saavedra ◽  
María Rosa Aguilar ◽  
Clara Escudero-Duch ◽  
Sergio Martín-Saldaña ◽  
...  
Keyword(s):  
Block Copolymers ◽  
Polymeric Nanoparticles ◽  
Tocopheryl Succinate ◽  
Photodynamic Activity

Facile synthesis of highly pure block copolymers by combination of RAFT polymerization, click reaction and de-grafting process

2012 ◽  
Vol 3 (7) ◽  
pp. 1803-1812 ◽  
Author(s):  
Guangdong Zhao ◽  
Peipei Zhang ◽  
Chengbo Zhang ◽  
Youliang Zhao
Keyword(s):  
Block Copolymers ◽  
Click Reaction ◽  
Raft Polymerization ◽  
Facile Synthesis ◽  
Pure Block

Synthesis of well-defined polymers grafted onto fumed silica by chain exchange reaction and highly pure block copolymers thereby

2010 ◽  
Vol 46 (39) ◽  
pp. 7397 ◽  
Author(s):  
Tengteng Hou ◽  
Peipei Zhang ◽  
Xiangdong Zhou ◽  
Xiangqian Cao ◽  
Youliang Zhao
Keyword(s):  
Block Copolymers ◽  
Exchange Reaction ◽  
Fumed Silica ◽  
Pure Block

Miniaturised preparation of polymeric nanoparticles using droplet manipulation on open surfaces

2019 ◽  
Vol 14 (13) ◽  
pp. 1312-1316 ◽  
Author(s):  
Alsaeed M. Abualsayed ◽  
Sara A. Abouelmagd ◽  
Mohamed Abdelgawad
Keyword(s):  
Polymeric Nanoparticles ◽  
Droplet Manipulation

Self-Assembly of Hydrogels From Elastin-Mimetic Block Copolymers

2002 ◽  
Vol 724 ◽  
Author(s):  
Elizabeth R. Wright ◽  
R. Andrew McMillan ◽  
Alan Cooper ◽  
Robert P. Apkarian ◽  
Vincent P. Conticello
Keyword(s):  
Block Copolymers ◽  
Self Assembly ◽  
Triblock Copolymers ◽  
Variable Temperature ◽  
Inverse Temperature ◽  
Temperature Transition ◽  
Scanning Calorimetry ◽  
Design Synthesis ◽  
Inverse Temperature Transition ◽  
Functional Biomaterials

AbstractTriblock copolymers have traditionally been synthesized with conventional organic components. However, triblock copolymers could be synthesized by the incorporation of two incompatible protein-based polymers. The polypeptides would differ in their hydrophobicity and confer unique physiochemical properties to the resultant materials. One protein-based polymer, based on a sequence of native elastin, that has been utilized in the synthesis of biomaterials is poly (Valine-Proline-Glycine-ValineGlycine) or poly(VPGVG) [1]. This polypeptide has been shown to have an inverse temperature transition that can be adjusted by non-conservative amino acid substitutions in the fourth position [2]. By combining polypeptide blocks with different inverse temperature transition values due to hydrophobicity differences, we expect to produce amphiphilic polypeptides capable of self-assembly into hydrogels. Our research examines the design, synthesis and characterization of elastin-mimetic block copolymers as functional biomaterials. The methods that are used for the characterization include variable temperature 1D and 2D High-Resolution-NMR, cryo-High Resolutions Scanning Electron Microscopy and Differential Scanning Calorimetry.

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