Signal Transduction and Molecular Targets of Dietary Cancer-Preventive Phytochemicals

2013 ◽  
pp. 81-106
Author(s):  
Ann Bode ◽  
Zigang Dong
Keyword(s):  
Signal Transduction ◽  
Molecular Targets

scholarly journals The molecular mechanisms of multidrug resistance of human glioblastomas

2021 ◽  
Vol 67 (1) ◽  
pp. 20-28
Author(s):  
Alexandr Chernov ◽  
Irina Baldueva ◽  
Tatyana Nekhaeva ◽  
Elvira Galimova ◽  
Diana Alaverdian ◽  
...  
Keyword(s):  
Signal Transduction ◽  
Drug Resistance ◽  
Transcription Factors ◽  
Growth Factors ◽  
Multidrug Resistance ◽  
Tumor Suppressor Genes ◽  
Molecular Mechanisms ◽  
Molecular Targets ◽  
Polymorphic Variants ◽  
Signal Transduction Proteins

In review discusses the phenomenon of drug resistance of GB in the context of the expression of ABC family transporter proteins and the processes of proliferation, angiogenesis, recurrence and death. The emphasis is on the identifying for molecular targets among growth factors, receptors, signal transduction proteins, microRNAs, transcription factors, proto-oncogenes, tumor suppressor genes and their polymorphic variants (SNPs) for the development and creation of targeted anticancer drugs.

scholarly journals Molecular targets for therapy, signal transduction inhibition and imatinib

Leukemia ◽  
2002 ◽  
Vol 16 (7) ◽  
pp. 1205-1205 ◽  
Author(s):  
N Muller-Bérat Killmann ◽  
JA McCubrey
Keyword(s):  
Signal Transduction ◽  
Molecular Targets

Detection of signal transduction molecular targets in gastrointestinal tumours

2004 ◽  
Vol 42 (05) ◽  
Author(s):  
F Pintér ◽  
L Berta ◽  
K Diófalvi ◽  
T Micsik ◽  
E Schäfer ◽  
...  
Keyword(s):  
Signal Transduction ◽  
Molecular Targets ◽  
Gastrointestinal Tumours

The opposite effects of IL-15 and IL-21 on CLL B cells correlate with differential activation of the JAK/STAT and ERK1/2 pathways

Blood ◽  
2008 ◽  
Vol 111 (2) ◽  
pp. 517-524 ◽  
Author(s):  
Daniela de Totero ◽  
Raffaella Meazza ◽  
Matteo Capaia ◽  
Marina Fabbi ◽  
Bruno Azzarone ◽  
...  
Keyword(s):  
Signal Transduction ◽  
Cell Proliferation ◽  
Molecular Targets ◽  
Clonal Expansion ◽  
Lymphocytic Leukemia ◽  
Cross Linking ◽  
Signal Transduction Pathways ◽  
The Common ◽  
Cell Expression ◽  
New Molecular Targets

The clonal expansion of chronic lymphocytic leukemia (CLL) cells requires the interaction with the microenvironment and is under the control of several cytokines. Here, we investigated the effect of IL-15 and IL-21, which are closely related to IL-2 and share the usage of the common γ chain and of its JAK3-associated pathway. We found remarkable differences in the signal transduction pathways activated by these cytokines, which determined different responses in CLL cells. IL-15 caused cell proliferation and prevented apoptosis induced by surface IgM cross-linking. These effects were more evident in cells stimulated via surface CD40, which exhibited increased cell expression of IL-15Rα chain and, in some of the cases, also of IL-2Rβ. IL-21 failed to induce CLL cell proliferation and instead promoted apoptosis. Following cell exposure to IL-15, phosphorylation of STAT5 was predominantly observed, whereas, following stimulation with IL-21, there was predominant STAT1 and STAT3 activation. Moreover, IL-15 but not IL-21 caused an increased phosphorylation of Shc and ERK1/2. Pharmacological inhibition of JAK3 or of MEK, which phosphorylates ERK1/2, efficiently blocked IL-15–induced CLL cell proliferation and the antiapoptotic effect of this cytokine. The knowledge of the signaling pathways regulating CLL cell survival and proliferation may provide new molecular targets for therapeutic intervention.

scholarly journals Pharmacodynamic drug interactions

2014 ◽  
Vol 1 (2) ◽  
pp. 96-99
Author(s):  
Hocine GACEM ◽  
◽  
Amel Ahmane
Keyword(s):  
Signal Transduction ◽  
Drug Interactions ◽  
Drug Target ◽  
Molecular Targets ◽  
Drug Action ◽  
Synergistic Action ◽  
Pharmacological Effect ◽  
Pharmacodynamic Interactions ◽  
Site Of Action ◽  
Signal Transduction Systems

Pharmacodynamic interactions are manifested by a change in pharmacological effect at the site of action. There may be a synergistic action, a potentiation or antagonism. Pharmacodynamic interactions are predictable and preventable since the mechanisms of drug action are defined in advance, the interaction drug-target is systematically described and various effectors and signal transduction systems are highlighted. Any time the plurality of molecular targets of the same drug should be considered when prescribing. The wide diffusion of pharmacological information and the updating of knowledge are then two tools to manage this kind of interaction.

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