Vitamins E and C

2013 ◽  
pp. 127-156
Author(s):  
Jean-Marc Zingg ◽  
Mohsen Meydani ◽  
Angelo Azzi
Keyword(s):  
Vitamins E And C

Lymphocyte DNA damage in rats exposed to pyrethroids: effect of supplementation with Vitamins E and C

Toxicology ◽  
2004 ◽  
Vol 203 (1-3) ◽  
pp. 17-26 ◽  
Author(s):  
Rosita Gabbianelli ◽  
Cinzia Nasuti ◽  
Giancarlo Falcioni ◽  
Franco Cantalamessa
Keyword(s):  
Dna Damage ◽  
Vitamins E And C

scholarly journals Phosalone Toxicity on Liver and Pancreas: Role of Vitamins E and C

2013 ◽  
Vol 25 (5) ◽  
pp. 2589-2592
Author(s):  
Hilmi Demirin ◽  
Osman Gökalp ◽  
Ertugrul Kaya ◽  
Bora Büyükvanli ◽  
Gökhan Cesur ◽  
...  
Keyword(s):  
Vitamins E And C ◽  
Liver And Pancreas

Antioxidants (vitamins E and C) decrease Bcl2/increase apoptosis in eutopic endometrium of women with endometriosis

2004 ◽  
Vol 82 ◽  
pp. S166-S167 ◽  
Author(s):  
M. Song ◽  
C. Dominguez ◽  
E. Lowe ◽  
S. Parthasarathy ◽  
A.A. Murphy
Keyword(s):  
Eutopic Endometrium ◽  
Vitamins E And C

scholarly journals Antioxidative defense

2011 ◽  
Vol 65 (3-4) ◽  
pp. 247-256
Author(s):  
Jelka Stevanovic ◽  
Suncica Borozan ◽  
Slavoljub Jovic ◽  
Igor Ignjatovic
Keyword(s):  
Free Radicals ◽  
Glutathione Peroxidase ◽  
Coenzyme Q ◽  
Cellular Protein ◽  
The Body ◽  
Antioxidative Defense ◽  
Cellular Defense ◽  
Physiological Processes ◽  
Vitamins E And C ◽  
And Control

Free radicals occur constantly during metabolism and take part in numerous physiological processes, such as: intra-cellular and inter-cellular signalization, gene expression, removal of damaged or senescent cells, and control of the tone of blood vessels. However, there is an increased quantity of free radicals in situations of so-called oxidative stress, when they cause serious damage to cellular membranes (peroxidation of their lipids, damage of membrane proteins, and similar), to interior cellular protein molecules, as well as DNA molecules and carbohydrates. This is precisely why the organism has developed numerous mechanisms for removing free radicals and/or preventing their production. Some of these are enzyme-related and include superoxide-dismutase, catalase, glutathione-peroxidase, and others. Other, non-enzyme mechanisms, imply antioxidative activities of vitamins E and C, provitamin A, coenzyme Q, reduced glutation, and others. Since free radicals can leave the cell that has produced them and become dispersed throughout the body, in addition to antioxidative defense that functions within cellular structures, antioxidant extra-cellular defense has also been developed. This is comprised by: transferrin, lactoferrin, haptoglobin, hemopexin, ceruloplasmin, albumins, extra-cellular isoform SOD, extracellular glutathione-peroxidase, glucose, bilirubin, urates, and many other molecules.

scholarly journals Biochemical criteria for the development mechanisms of various reproduction disorders in dairy cows

2021 ◽  
Vol 22 (11) ◽  
Author(s):  
Inna Ventsova ◽  
VLADIMIR SAFONOV
Keyword(s):  
Oxidative Stress ◽  
Dairy Cows ◽  
Malonic Dialdehyde ◽  
Antioxidant Protection ◽  
Factors Analysis ◽  
Gonadal Dysfunction ◽  
Vitamins E And C ◽  
Endocrine Status ◽  
Nitric Oxide Metabolites ◽  
Uterine Diseases

Abstract. Ventsova I, Safonov V. 2021. Biochemical criteria for the development mechanisms of various reproduction disorders in dairy cows. Biodiversitas 22: 4997-5002. The article presents the evaluation of peroxide, antioxidant, and hormonal conditions of high-producing red-and-white dairy cows in the physiological and pathological course of pregnancy and the postpartum period. The blood concentration of malonic dialdehyde, stable nitric oxide metabolites, S-nitrosothiols, vitamins E and C, carotin, gonadal, corticosteroid, and thyroid hormones, as well as activity of GPx, GR, SOD, catalase, and ceruloplasmin, were estimated to define major disorder-provoking factors. Analysis of the data shows that ketosis-gestosis syndrome during pregnancy, postpartum metritis, and gonadal dysfunction occur mainly because of oxidative stress in the context of unbalanced peroxide responses and antioxidant protection. Levels of malonic dialdehyde compared to healthy animals increased by 42.3%, 75%, 56.6%, respectively, as also enzyme activities of GR by 26%, 68.1%, 30.1% and catalase by 17.3%, 45.1%, and 23.9%, correspondingly. The endocrine status indicators in the animals with ketosis-gestosis syndrome changed as follows: progesterone levels were 29.5% lower in cows, 17?-estradiol and cortisol were 20.8% and 14.7% lower, respectively. In animals with inflammatory uterine diseases and depressing reproductive glands, progesterone level was 2 and 3 times lower than in healthy animals, the content of cortisol was 17.6% and 25.1% lower, and testosterone decreased by 21.4% and 75.1%, respectively.

scholarly journals Variegate porphyria induces plasma and neutrophil oxidative stress: effects of dietary supplementation with vitamins E and C

2009 ◽  
Vol 103 (1) ◽  
pp. 69-76 ◽  
Author(s):  
Miguel D. Ferrer ◽  
Pedro Tauler ◽  
Antoni Sureda ◽  
Clara Palacín ◽  
Josep A. Tur ◽  
...  
Keyword(s):  
Vitamin E ◽  
Vitamin C ◽  
Oxidative Damage ◽  
Antioxidant Activities ◽  
Dietary Supplementation ◽  
Antioxidant Defenses ◽  
Ros Production ◽  
Double Blind ◽  
Variegate Porphyria ◽  
Vitamins E And C

Our aim was to analyse the influence of variegate porphyria (VP) on the antioxidant defenses and markers of oxidative damage and inflammation in plasma and neutrophils and the effects of dietary supplementation with vitamins E and C on these parameters in plasma, neutrophils and erythrocytes. Twelve women affected by VP and twelve pair-matched healthy control women participated in a double-blind crossover study. Each participant took 50 mg/d of vitamin E and 150 mg/d of vitamin C, or a placebo, for 6 months, by consuming an almond-based beverage as the vehicle. Women affected by VP presented higher C-reactive protein and malondialdehyde (MDA) circulating levels. Plasma antioxidant defenses were not different between porphyric and control women. Neutrophils from VP women presented decreased catalase (CAT) and glutathione reductase (GR) activities together with increased protein carbonyl levels. Reactive oxygen species (ROS) production from stimulated neutrophils was also higher in porphyric women than their controls. Dietary supplementation was effective in increasing α-tocopherol levels in neutrophils and in reducing MDA levels in plasma. Erythrocyte CAT and GR activities were enhanced by the enriched beverage only in the control subjects. In conclusion, women affected by VP present a situation of inflammation, plasma oxidative damage and neutrophils more primed to the oxidative burst, with decreased antioxidant activities and increased ROS production capabilities and protein oxidative damage. Dietary supplementation with vitamin E (50 mg/d) and vitamin C (150 mg/d) for 6 months decreased plasma oxidative damage and enhanced the erythrocyte activities of CAT and GR.

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