Drug Interactions with Nutrients and Natural Products

2013 ◽  
pp. 1067-1072
Author(s):  
David Greenblatt
Keyword(s):  
Natural Products ◽  
Drug Interactions

Transcriptome and Proteome Analyses of Drug Interactions with Natural Products

2008 ◽  
Vol 9 (10) ◽  
pp. 1038-1048 ◽  
Author(s):  
Hai Fang ◽  
Kankan Wang ◽  
Ji Zhang
Keyword(s):  
Natural Products ◽  
Drug Interactions

Revisiting CYP2C9-Mediated drug-drug Interactions: A Review

2021 ◽  
pp. 6166-6172
Author(s):  
Nurliana Abd Mutalib ◽  
Mohd Amirul Ariffin Mohd Rafi ◽  
Normala Abd Latip
Keyword(s):  
Natural Products ◽  
Reference Material ◽  
Drug Interactions ◽  
Phase 1 ◽  
Potential Drug ◽  
Health Practitioners ◽  
Clinical Drugs ◽  
Clinically Significant

Drug-drug interactions (DDI) are the most common cases that occur in our healthcare in which are very alarming as it may lead to severe complications. Consumption of natural products concomitantly with conventional drugs or treatment using polypharmacy have become the norm that promoting the potential of pharmacokinetic or pharmacodynamic drug interactions as the combination may mimic, increase or reduce the effects of the drug or the herb which could result in clinically significant interactions. CYP2C9 is the second major isoform from CYP450 family of enzyme, which responsible in phase 1 metabolism of 15-20% clinical drugs. Up to date, many substrates of CYP2C9 have been discovered and these discoveries may open more doors for potential drug-drug interactions in patients. Many studies have been done to evaluate the effect of drugs on the activity of CYP2C9 and how it influenced the effectiveness of therapy in patients. Various data regarding CYP2C9 related DDI from in vitro, in vivo and clinical studies were critically discussed in this review to provide insights on how these drugs and natural products may exhibit drug interactions clinically. This review could be beneficial reference material for health practitioners and researchers.

scholarly journals Selection of Priority Natural Products for Evaluation as Potential Precipitants of Natural Product–Drug Interactions: A NaPDI Center Recommended Approach

2018 ◽  
Vol 46 (7) ◽  
pp. 1046-1052 ◽  
Author(s):  
Emily J. Johnson ◽  
Vanessa González-Peréz ◽  
Dan-Dan Tian ◽  
Yvonne S. Lin ◽  
Jashvant D. Unadkat ◽  
...  
Keyword(s):  
Natural Products ◽  
Drug Interactions ◽  
Natural Product ◽  
Selection Of

scholarly journals Pregnane X receptor and natural products: beyond drug–drug interactions

2006 ◽  
Vol 2 (6) ◽  
pp. 847-857 ◽  
Author(s):  
Jeff L Staudinger ◽  
Xunshan Ding ◽  
Kristin Lichti
Keyword(s):  
Natural Products ◽  
Drug Interactions ◽  
Pregnane X Receptor

Inhibition of CYP2C9 by natural products: insight into the potential risk of herb-drug interactions

2020 ◽  
Vol 52 (2) ◽  
pp. 235-257 ◽  
Author(s):  
Kai Wang ◽  
Qing Gao ◽  
Tingting Zhang ◽  
Jinqiu Rao ◽  
Liqin Ding ◽  
...  
Keyword(s):  
Natural Products ◽  
Drug Interactions ◽  
Potential Risk ◽  
Insight Into
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