Physiology, Pharmacology, and Pathophysiology of the D1-like Family of Dopamine Receptors in the Central Nervous System

2003 ◽  
pp. 149-200
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Dopamine Receptors ◽  
The Central Nervous System

Dopamine Receptors in the Central Nervous System

1982 ◽  
pp. 255-301 ◽  
Author(s):  
Ian Creese ◽  
A. Leslie Morrow ◽  
Stuart E. Leff ◽  
David R. Sibley ◽  
Mark W. Hamblin
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Dopamine Receptors ◽  
The Central Nervous System

scholarly journals Dopaminergic modulation of Na+, K+ and GABA-activated currents in neurons of the mammalian central nervous system

2013 ◽  
Vol 11 (1) ◽  
pp. 3-13
Author(s):  
Anna Aleksandrovna Bukinich ◽  
Petr Dmitriyevich Shabanov
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Dopamine Receptors ◽  
Mammalian Central Nervous System ◽  
System A ◽  
Dopaminergic Modulation ◽  
The Central Nervous System ◽  
Modulating Functions

He modern investigations of dopaminergic modulation of voltage-depended Na+, K+ and GABA-activated currents in neurons of the mammalian central nervous system are reviewed in the paper. On the base of own findings and literature data concerning modulating functions of dopamine on voltage-depended Na+, K+ and GABA-activated currents in neurons of the mammalian central nervous system was shown that dopamine caused individual and often not one-directed effect in various neurons of the central nervous system. A type of dopamine effect can be determined by the prevalence of the class/type of dopamine receptors on membrane of a neuron.

The dopamine receptor in adult and maturing kidney

1989 ◽  
Vol 257 (3) ◽  
pp. F315-F327 ◽  
Author(s):  
R. A. Felder ◽  
C. C. Felder ◽  
G. M. Eisner ◽  
P. A. Jose
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Adenylate Cyclase ◽  
Dopamine Receptors ◽  
Dopamine Receptor ◽  
Receptor Activation ◽  
Receptor Subtypes ◽  
The Central Nervous System ◽  
Renal Tubular ◽  
Da2 Receptor

Dopamine, like other neurotransmitters, exerts its biological effects by occupation of specific receptor subtypes. The dopamine receptors in the central nervous system and certain endocrine organs are classified into the D1/D2 subtypes. Outside the central nervous system, the dopamine receptors are classified into the DA1/DA2 subtypes. The D1/D2 and DA1/DA2 receptor have marked similarities and some differences, the most notable of which is the lower affinity of the DA dopamine compared with the D dopamine receptor. DA1 receptor activation increases renal blood flow (RBF); stimulation of DA1 and DA2 receptors may also increase glomerular filtration rate (GFR). DA1 agonists inhibit fluid and electrolyte transport indirectly via hemodynamic mechanisms and directly by occupation of DA1 receptors in specific nephron segments. In the proximal tubule, DA1 agonists simulate adenylate cyclase and inhibit Na+-H+ antiport activity. They also increase phospholipase C and inhibit Na+-K+-ATPase activity (presumably as a consequence of protein kinase C activation). The latter effects may be facilitated by DA2 agonists. In cortical collecting ducts, dopamine antagonizes the effects of mineralocorticoids and the hydrosomotic effect of antidiuretic hormone. It has also been suggested that DA1 may also decrease sodium transport by influencing other hormones, such as atrial natriuretic peptide. Studies of dopamine in the young are complicated because of the propensity for dopamine to stimulate alpha-adrenoceptors. Dopamine alone may actually decrease RBF in the perinatal period. In some animals, the renal vasodilatory and natriuretic effects of dopamine increase with age. Renal tubular DA1-stimulated adenylate cyclase activity increases, whereas renal tubular DA1 receptors decrease with age. Renal DA2 receptor density is greater in the fetus; after birth renal DA2 receptors do not change. Endogenous dopamine may regulate sodium excretion in the young differently than in the adult. In the adult, sodium surfeit is associated with an increase in urinary dopamine; the opposite occurs in the young. A decrease in dopamine production or blockade of dopamine receptors results in an antinatriuresis in the adult; dopamine blockade in the young results in a natriuresis. It remains to be determined whether these age-related differences in dopamine effects are due to changes in receptor DA subtype density, second messengers, and/or interaction with other receptors.

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