Cerebrovascular Disease and Sleep Apnea

Sleep Apnea ◽  
2000 ◽  
pp. 306-327 ◽  
Keyword(s):  
Sleep Apnea ◽  
Cerebrovascular Disease

Abstract WP189: Prediction of Apnea Hypopnea Index among Stroke and TIA Patients

Stroke ◽  
2013 ◽  
Vol 44 (suppl_1) ◽  
Author(s):  
Jason Sico ◽  
Susan Ofner ◽  
H. Klar Yaggi ◽  
Dawn Bravata
Keyword(s):  
Blood Pressure ◽  
Sleep Apnea ◽  
Prediction Model ◽  
Cerebrovascular Disease ◽  
Medical History ◽  
Neck Circumference ◽  
Apnea Hypopnea Index ◽  
Berlin Questionnaire ◽  
Past Medical History ◽  
Obstructive Sleep

INTRODUCTION: Obstructive sleep apnea (OSA) is common among patients with stroke and TIA. Previously validated OSA screening instruments used in the general population are largely based on reported symptoms; when applied to those with cerebrovascular disease, they have shown poor correlation with the presence of OSA diagnosed via polysomnography (PSG). We sought to develop a cerebrovascular disease specific prediction model for OSA that is less reliant on symptomatology. Methods: We used data from a multi-site randomized, controlled strategy trial that included ischemic stroke and TIA patients at two VA hospitals. Data on patient demographics, vital signs, anthropomorphic measurements, past medical history, medications, stroke severity, and sleep questionnaires were obtained. All patients received PSG. Sleep apnea was defined as present if the apnea-hypopnea index (AHI) was ≥5. Because approximately half of subjects had OSA, discrimination was difficult; thus, AHI was used as the outcome for our prediction model. Epworth Sleepiness Scale (ESS)≥10, the Berlin Questionnaire>10, and Sleep Apnea Clinical Score (SACS)≥15 were considered ‘high risk’ for OSA. Bivariate regression models were used to assess the strength of the association between predictors and the outcome (log AHI+1); those statistically significant at the 0.1 level were entered into a multi-variable regression model. Backward elimination was used until all remaining variables were significant at the 0.05 level. Results: Among 194 Veterans, 119 (61.3%) had an AHI≥5. Neck circumference > 16 inches, systolic blood pressure less than 132 mmHg, peripheral vascular disease, and recent hospitalization for congestive heart failure were associated with increase in log AHI; history of chronic obstructive pulmonary disease/asthma was associated with a decrease in log AHI (R2=0.13). ESS≥10 (p=0.86) and Berlin Questionnaire >10 (p=0.80) were not associated with log AHI. The SACS≥15 was associated with AHI (p=0.01); however, it did not remain significant in the final model. Conclusions: A model using blood pressure, neck circumference and past medical history data was predictive of AHI. Further work is required to validate the use of this model in a larger cerebrovascular disease cohort.

Structural and serum surrogate markers of cerebrovascular disease in obstructive sleep apnea (OSA)

2006 ◽  
Vol 253 (6) ◽  
pp. 746-752 ◽  
Author(s):  
M. Saletu ◽  
D. Nosiska ◽  
G. Kapfhammer ◽  
W. Lalouschek ◽  
B. Saletu ◽  
...  
Keyword(s):  
Obstructive Sleep Apnea ◽  
Sleep Apnea ◽  
Cerebrovascular Disease ◽  
Surrogate Markers ◽  
Obstructive Sleep

scholarly journals Diagnosing and Treating Sleep Apnea in Patients With Acute Cerebrovascular Disease

2018 ◽  
Vol 7 (16) ◽  
Author(s):  
Dawn M. Bravata ◽  
Jason Sico ◽  
Carlos A. Vaz Fragoso ◽  
Edward J. Miech ◽  
Marianne S. Matthias ◽  
...  
Keyword(s):  
Sleep Apnea ◽  
Cerebrovascular Disease

Sleep Apnea and the Cerebrovascular Disease Correlation

2014 ◽  
Vol 14 (1) ◽  
pp. 31-32
Author(s):  
B. Hoyle ◽  
A. Culebras
Keyword(s):  
Sleep Apnea ◽  
Cerebrovascular Disease

scholarly journals The Burden of Associated Comorbidities in Patients with Obstructive Sleep Apnea—Regional Differences in Two Central–Eastern European Sleep Centers

2020 ◽  
Vol 9 (11) ◽  
pp. 3583
Author(s):  
Andras Bikov ◽  
Stefan Frent ◽  
Roxana Pleava ◽  
Laszlo Kunos ◽  
Saba Bokhari ◽  
...  
Keyword(s):  
Cardiovascular Disease ◽  
Obstructive Sleep Apnea ◽  
Sleep Apnea ◽  
Cerebrovascular Disease ◽  
Inverse Correlation ◽  
Cerebrovascular Diseases ◽  
Smoking History ◽  
Chronic Obstructive ◽  
Prevalence Rates ◽  
Obstructive Sleep

Background: Obstructive sleep apnea (OSA) is usually associated with cardiovascular and cerebrovascular disease, metabolic syndrome and depression. Data on relevant OSA-associated comorbidities in Central–European populations are scarce. The aim of this study was to compare the prevalence of comorbidities in two OSA cohorts from Hungary and Romania. Methods: Data from 588 (282 from Hungary, 306 from Romania) untreated patients with OSA were retrospectively analyzed. The prevalence rates of hypertension, diabetes, dyslipidemia, allergic rhinitis, asthma, chronic obstructive pulmonary disease (COPD), osteoporosis, cerebrovascular and cardiovascular disease, arrhythmia and depression were compared between the two populations following adjustment for demographics, body mass index, smoking history, comorbidities and sleep parameters. Results: The prevalence rates of hypertension, arrhythmia, cerebrovascular and cardiovascular disease, diabetes and COPD in the whole study population were directly related to the severity of OSA. We found an inverse correlation between the prevalence of osteoporosis and OSA severity (all p < 0.05). Following adjustment, the prevalence of dyslipidemia was higher in the Hungarian cohort, whilst the prevalence of asthma, cardiovascular and cerebrovascular diseases was higher in the Romanian cohort (all p < 0.05). Conclusions: There was no difference in the prevalence rate of most comorbidities in patients with OSA from the two cohorts, except for dyslipidemia, asthma, cardiovascular and cerebrovascular disease.

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