Noninvasive Clinical Assessment of Skin Irritation/Inflammation

3: Final Report on the Safety Assessment of Coconut Oil, Coconut Acid, Hydrogenated Coconut Acid, and Hydrogenated Coconut Oil

Journal of the American College of Toxicology ◽

10.3109/10915818609141927 ◽

1986 ◽

Vol 5 (3) ◽

pp. 103-121

Keyword(s):

Clinical Assessment ◽

Safety Assessment ◽

Skin Irritation ◽

Coconut Oil ◽

Laboratory Animals ◽

Final Report ◽

Cosmetic Products ◽

Oral Toxicity ◽

Eye Irritation ◽

Foaming Agent

In cosmetic products, Coconut Oil is used as a cleanser, foaming agent, or stabilizer at concentrations up to 50%. Acute, chronic, and subchronic oral toxicity studies indicate that Coconut Oil and Hydrogenated Coconut Oil are relatively nontoxic byingestion. Neither compound produced significant skin or eye irritation in laboratory animals. No sensitization was reported. Clinical assessment of cosmetic products containing Coconut Oil produced very minimal skin irritation reactions. There was no indication that theseingredients were primary irritants, sensitizers, or phototoxic compounds following human testing. It is concluded that Coconut Oil, Coconut Acid, Hydrogenated Coconut Oil, and Hydrogenated Coconut Acid are safe for use as cosmeticingredients.

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5 Final Report on the Safety Assessment of Zinc Phenolsulfonate

Journal of the American College of Toxicology ◽

10.3109/10915818609141917 ◽

1986 ◽

Vol 5 (5) ◽

pp. 373-390

Keyword(s):

Growth Inhibition ◽

Patch Test ◽

Clinical Assessment ◽

Safety Assessment ◽

Skin Irritation ◽

Metabolic Activation ◽

Final Report ◽

Cosmetic Products ◽

Feeding Study ◽

Significant Toxicity

Zinc Phenolsulfonate is a substituted phenol used in cosmetic products as an antimicrobial and astringent at concentrations up to 5%. This compound was moderately toxic when administered orally. No deaths or growth inhibition were reported in a 91-day rat feeding study. No significant toxicity was reported when Zinc Phenolsulfonate was applied dermally in acute and sub-chronic studies. A single insult patch test of a 5% aqueous Zinc Phenolsulfonate solution was negative for skin irritation in rabbits. Minimal skin irritation was reported when 100% Zinc Phenolsulfonate was tested. The Buehler test for delayed sensitization was negative. No eye irritation was observed in rabbits exposed to 5% aqueous Zinc Phenolsulfonate and only moderate irritation at 100%. No mutagenicity was observed when Zinc Phenolsulfonate was tested with and without metabolic activation in five Salmonella strains. Clinical assessment of Zinc Phenolsulfonate with product formulations indicated that Zinc Phenolsulfonate was at most a mild skin irritant in normal use, but not a sensitizer. It is concluded that Zinc Phenolsulfonate is safe as a cosmetic ingredient in the present practices of use and concentration.

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