Surgical Staging of Apparent Early-Stage Uterine and Adnexal Malignancies

2013 ◽  
pp. 12-43
Author(s):  
Eric Eisenhauer ◽  
Yukio Sonoda
Keyword(s):  
Early Stage ◽  
Surgical Staging

Retrospective analysis of stage IC uterine cancer patients: A single center experience.

2012 ◽  
Vol 30 (15_suppl) ◽  
pp. e15573-e15573
Author(s):  
Nadire Kucukoztas ◽  
Selim Yalcin ◽  
Samed Rahatli ◽  
Ozlem Ozen ◽  
Nihan Haberal ◽  
...  
Keyword(s):  
Endometrial Cancer ◽  
Early Stage ◽  
Uterine Cancer ◽  
Endometrial Adenocarcinoma ◽  
Cell Cancer ◽  
Disease Free Survival ◽  
Figo Stage ◽  
Surgical Staging ◽  
Increased Risk

e15573 Background: Stage IC patients are at an increased risk of recurrence and overall worse prognosis compared with stage IA and IB patients. Adjuvant chemoherapy is utilized based on specific pathologic factors. The objective of this study is to evaluate treatment outcomes at a single institution in patients with 1988 FIGO stage IC endometrial adenocarcinoma. Methods: Records of the patients with FIGO stage IB (formerly IC) endometrial cancer were retrospectively evaluated. All patients were initially treated surgically with comprehensive staging lymphadenectomy. Results: A total of 85 patients were included. Patient and tumor characteristics are shown in the table. Median age of the patients was 60 (range 27-95). Fifty-nine patients had at least one co-morbid disease. Complete surgical staging including pelvic and paraaortic lymph node dissection was performed in all the patients. Sixteen patients (19%) received adjuvant chemotherapy, including 6 patients with serous cancer and one patient with small cell cancer. Paclitaxel/carboplatin was the preferred regimen in Median follow up was 30 months (range 10-61 months). Seven patients (8%) relapsed and 4 patients (5%) died on follow up. 5 year disease free survival was 89% and overall survival was 95%. One of the 16 patients (6.2%) who received chemotherapy and 6 of the 69 patients (8.7%) who did not receive relapsed/died on follow up. Survival analysis was not performed because of the low number of events in both groups. Conclusions: We found similar rates of recurrence and death with previous studies in stage IC endometrial cancer. Complete surgical staging is the mainstay of treatment. Marginally lower recurrence rate in chemotherapy treated patients delineate the need for prospective randomized data addressing the role of adjuvant systemic therapy in early-stage patients with endometrial adenocarcinoma. [Table: see text]

Screening in the high-risk populations: Stage of breast cancer when detected by combination imaging with MRI and mammogram.

2013 ◽  
Vol 31 (26_suppl) ◽  
pp. 44-44
Author(s):  
Kendall W. Carpenter ◽  
Mindy L. Merritt ◽  
Matthew Gromet ◽  
Karinn Marie Chambers ◽  
Terry Sarantou ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Family History ◽  
High Risk ◽  
Early Stage ◽  
Brca Mutation ◽  
Assessment Tools ◽  
Surgical Staging ◽  
Node Positive ◽  
Node Positive Disease ◽  
Malignant Lesions

44 Background: Screening patients at high-risk for the development of breast cancer consists of MRI and mammography. This retrospective review of screening MRIs in patients designated as high-risk for the development of breast cancer--based on family history alone or a calculated lifetime risk of ≥ 20%--seeks to determine the utility of MRI screening in the detection of early-stage breast cancer. The primary outcome evaluated was stage of malignancy detected through screening imaging.  Methods: Results of screening imaging performed between 1/1/08 and 12/31/11 were retrospectively reviewed. Patients who had a personal history of breast cancer were excluded. Remaining screens were categorized based on the following criteria: family history, BRCA mutation or high-risk as calculated by risk assessment tools. Screens with corresponding core biopsies were evaluated for the following: previous imaging obtained, core biopsy pathology and pathologic staging. Results: 118 patients met inclusion criteria and had a subsequent biopsy as a result of screening. Resultant pathology was 75 (64%; 75/118) benign lesions, 19 (16%; 19/118) atypical lesions, and 24 (20%; 24/118) malignant lesions. Of the 24 malignant lesions, 1 (4%; 1/24) were found to be node-positive at the time of surgical staging, and, 23 (96%; 23/24) were node-negative. Conclusions: Four percent (1/24) of patients undergoing high-risk screening had nodal disease at surgical staging, which compares favorably to historical rates of approximately 30% node-positive disease at diagnosis (Krag DN et al., NSABP B-32). Therefore, this study shows that screening high-risk patients can decrease the nodal-positivity rate.

The role of pelvic and aortic lymphadenectomy at second look surgery in apparent early stage ovarian cancer after inadequate surgical staging followed by adjuvant chemotherapy

2014 ◽  
Vol 132 (2) ◽  
pp. 312-315 ◽  
Author(s):  
Mauro Signorelli ◽  
Robert Fruscio ◽  
Lorenzo Ceppi ◽  
Tiziana Dell'Anna ◽  
Domenico Vitobello ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Adjuvant Chemotherapy ◽  
Early Stage ◽  
Surgical Staging ◽  
Second Look ◽  
Early Stage Ovarian Cancer

Laparoscopic versus laparotomic surgical staging for early-stage epithelial ovarian cancer

2011 ◽  
Vol 120 ◽  
pp. S72 ◽  
Author(s):  
J. Park ◽  
D. Kim ◽  
J. Kim ◽  
Y. Kim ◽  
Y. Kim ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Epithelial Ovarian Cancer ◽  
Early Stage ◽  
Surgical Staging

scholarly journals Incomplete Staging in Ovarian Cancer

2020 ◽  
Author(s):  
Jogchum Beltman ◽  
P Laven ◽  
JE Bense ◽  
Maaike van der Aa ◽  
MC Vos ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Lymph Nodes ◽  
Early Stage ◽  
Pelvic Lymph Node Dissection ◽  
Surgical Staging ◽  
Evidence Based ◽  
National Guidelines ◽  
Obstetrics And Gynaecology ◽  
Analysis Technique ◽  
Do So

Abstract Objective Incomplete surgical staging of patients with early stage epithelial ovarian cancer (EOC) has been reported in up to 85% of cases, when based on the International Federation of Obstetrics and Gynaecology (FIGO) staging procedure. The aim of the present retrospective study was to clarify the reasons for incomplete staging.Methods The PRISMA (Prevention Recovery Information System for Monitoring and Analysis) technique was used to evaluate cases with FIGO I-IIa EOC based on incomplete staging from five gynecologic oncologic center hospitals in the Netherlands in the period 2010-2014.Results Fifty cases with an incomplete surgical staging of EOC according to national guidelines were included. The most common reasons for incomplete staging were insufficient random biopsies of the peritoneum (n=34, 68%), and less than ten lymph nodes being resected and/or found at pathology (n=16, 32%). The most mentioned reasons for not performing biopsies were forgetting to do so, and believing that after careful inspection and palpation, taking biopsies is irrelevant and/or already are being taken while performing a hysterectomy (cul-de-sac, bladder). The value of contralateral pelvic lymph node dissection in case of a unilateral ovarian malignancy was also doubted, influencing the number of lymph nodes resected.Conclusion The most important reasons for incomplete staging in EOC are, besides omitting elements by accident, questioning the importance of obligatory elements of the staging procedure. A structured list of staging steps during surgery and more evidence based consensus concerning these obligatory elements might increase the number of complete staging procedures in EOC.

Laparoscopic Versus Laparotomic Surgical Staging for Early Stage Epithelial Ovarian Cancer

2011 ◽  
Vol 18 (6) ◽  
pp. S59 ◽  
Author(s):  
J-Y. Park ◽  
D-Y. Kim ◽  
J-H. Kim ◽  
Y-M. Kim ◽  
Y-T. Kim ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Epithelial Ovarian Cancer ◽  
Early Stage ◽  
Surgical Staging
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