Sophorolipids: Production, Characterization and Biologic Activity

2013 ◽  
pp. 377-417 ◽  
Keyword(s):  
Biologic Activity

Upcoming Drifts In Bio-Similars

2020 ◽  
Vol 15 ◽  
Author(s):  
Geeta Aggarwal ◽  
Manju Nagpal ◽  
Ameya Sharma ◽  
Vivek Puri ◽  
Gitika Arora Dhingra
Keyword(s):  
Metabolic Diseases ◽  
Market Competition ◽  
Current Status ◽  
Medicinal Products ◽  
The Past ◽  
Biologic Activity ◽  
Emerging Trends ◽  
Regulatory Guidelines ◽  
Food Drug Administration ◽  
Insight Into

Background: Biopharmaceuticals such as Biologic medicinal products have been in clinical use over the past three decades and have benefited towards the therapy of degenerative and critical metabolic diseases. It is forecasted that market of biologics will be going to increase at a rate of 20% per year, and by 2025, more than ˃ 50% of new drug approvals may be biological products. The increasing utilization of the biologics necessitates for cost control, especially for innovators products that have enjoyed a lengthy period of exclusive use. As the first wave of biopharmaceuticals is expired or set to expire, it has led to various opportunities for the expansion of bio-similars i.e. copied versions of original biologics with same biologic activity. Development of biosimilars is expected to promote market competition, meet worldwide demand, sustain the healthcare systems and maintain the incentives for innovation. Methods: Appraisal of published articles from peer reviewed journals, PubMed literature, latest news and guidelines from European Medicine Agency, US Food Drug Administration (FDA) and India are used to identify data for review. Results: Main insight into the quality requirements concerning biologics, current status of regulation of biosimilars and upcoming challenges lying ahead for the upgrading of marketing authorization of bio-similars has been incorporated. Compiled literature on therapeutic status, regulatory guidelines and the emerging trends and opportunities of biosimilars has been thoroughly stated. Conclusion: Updates on biosimilars will support to investigate the possible impact of bio-similars on healthcare market.

scholarly journals A mutant insulin receptor with defective tyrosine kinase displays no biologic activity and does not undergo endocytosis.

1987 ◽  
Vol 262 (30) ◽  
pp. 14663-14671 ◽  
Author(s):  
D A McClain ◽  
H Maegawa ◽  
J Lee ◽  
T J Dull ◽  
A Ulrich ◽  
...  
Keyword(s):  
Tyrosine Kinase ◽  
Insulin Receptor ◽  
Biologic Activity ◽  
Mutant Insulin ◽  
Mutant Insulin Receptor

Chemistry of Water Collected from an Unventilated Drift, Yucca Mountain, Nevada

2006 ◽  
Vol 985 ◽  
Author(s):  
Brian D Marshall ◽  
Thomas A. Oliver ◽  
Zell E. Peterman
Keyword(s):  
Pore Water ◽  
Water Samples ◽  
Conveyor Belt ◽  
Yucca Mountain ◽  
Seepage Water ◽  
Biologic Activity ◽  
Co2 Concentrations ◽  
The Cross ◽  
Chemical Conditions

AbstractWater samples (referred to as puddle water samples) were collected from the surfaces of a conveyor belt and plastic sheeting in the unventilated portion of the Enhanced Characterization of the Repository Block (ECRB) Cross Drift in 2003 and 2005 at Yucca Mountain, Nevada. The chemistry of these puddle water samples is very different than that of pore water samples from borehole cores in the same region of the Cross Drift or than seepage water samples collected from the Exploratory Studies Facility tunnel in 2005. The origin of the puddle water is condensation on surfaces of introduced materials and its chemistry is dominated by components of the introduced materials. Large CO2 concentrations may be indicative of localized chemical conditions induced by biologic activity.

Synthesis and biologic activity of 3β-thiovitamin D3

1985 ◽  
Vol 23 (1) ◽  
pp. 81-85 ◽  
Author(s):  
James M. Londowski ◽  
Larry K. Revelle ◽  
Susan Bollman Kost ◽  
Robert A. Corradino ◽  
Rajiv Kumar
Keyword(s):  
Biologic Activity

scholarly journals bFGF and PDGF-BB for Tendon Repair: Controlled Release and Biologic Activity by Tendon Fibroblasts In Vitro

2009 ◽  
Vol 38 (2) ◽  
pp. 225-234 ◽  
Author(s):  
Stavros Thomopoulos ◽  
Rosalina Das ◽  
Shelly Sakiyama-Elbert ◽  
Matthew J. Silva ◽  
Nichole Charlton ◽  
...  
Keyword(s):  
Controlled Release ◽  
Tendon Repair ◽  
Biologic Activity

scholarly journals Binding and biologic activity of glucagon in liver cell membranes of chronically hyperglucagonemic rats.

1977 ◽  
Vol 252 (21) ◽  
pp. 7434-7436 ◽  
Author(s):  
C.B. Srikant ◽  
D. Freeman ◽  
K. McCorkle ◽  
R.H. Unger
Keyword(s):  
Liver Cell ◽  
Cell Membranes ◽  
Biologic Activity
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