Immune-Mediated Musculoskeletal and Neurological Disease

2011 ◽  
pp. 172-200
Author(s):  
Susan Shaw
Keyword(s):  
Neurological Disease ◽  
Immune Mediated

A potential link between autoimmunity and neurodegeneration in immune-mediated neurological disease

2011 ◽  
Vol 235 (1-2) ◽  
pp. 56-69 ◽  
Author(s):  
Sangmin Lee ◽  
Lijing Xu ◽  
Yoojin Shin ◽  
Lidia Gardner ◽  
Anastasia Hartzes ◽  
...  
Keyword(s):  
Neurological Disease ◽  
Immune Mediated ◽  
Potential Link

scholarly journals Paraneoplastic Diseases of the Central Nervous System

F1000Research ◽  
2020 ◽  
Vol 9 ◽  
pp. 167 ◽  
Author(s):  
Jonathan Galli ◽  
John Greenlee
Keyword(s):  
Cell Surface ◽  
Neurological Disease ◽  
Sensory Neuropathy ◽  
Tumor Type ◽  
Surface Binding ◽  
Antineuronal Antibodies ◽  
Immune Mediated ◽  
Clinical Presentations ◽  
The Central Nervous System ◽  
Paraneoplastic Antibody

Paraneoplastic neurological syndromes are nonmetastatic complications of malignancy secondary to immune-mediated neuronal dysfunction or death. Pathogenesis may occur from cell surface binding of antineuronal antibodies leading to dysfunction of the target protein, or from antibodies binding against intracellular antigens which ultimately leads to cell death. There are several classical neurological paraneoplastic phenotypes including subacute cerebellar degeneration, limbic encephalitis, encephalomyelitis, and dorsal sensory neuropathy. The patient’s clinical presentations may be suggestive to the treating clinician as to the specific underlying paraneoplastic antibody. Specific antibodies often correlate with the specific underlying tumor type, and malignancy screening is essential in all patients with paraneoplastic neurological disease. Prompt initiation of immunotherapy is essential in the treatment of patients with paraneoplastic neurological disease, often more effective in cell surface antibodies in comparison to intracellular antibodies, as is removal of the underlying tumor.

Antibodies in Autoimmune Human Neurological Disease: Pathogenesis and Immunopathology

2018 ◽  
Vol 38 (03) ◽  
pp. 267-277 ◽  
Author(s):  
Jon Williams ◽  
John Greenlee ◽  
Noel Carlson
Keyword(s):  
Neurological Disease ◽  
Neuronal Membrane ◽  
Disease Pathogenesis ◽  
Immune Mediated ◽  
Paraneoplastic Disease ◽  
Associated Malignancy ◽  
Membrane Antigens ◽  
Clinical Associations ◽  
Intracellular Targets ◽  
Antineural Antibodies

AbstractImmune-mediated processes represent a rapidly expanding categorical etiology for neurological disease manifestations spanning all subspecialties of neurology. Neural autoantibodies can be grossly divided into two main groups based on localization of the antigen: intracellular and cell membrane/synaptic antibodies. Antibodies reactive with neuronal membrane antigens have been identified in serum and cerebrospinal fluid of patients developing neurological disease either independent of or associated with cancer comorbidity, whereas antibodies directed against intracellular targets have a much higher rate of associated malignancy. Antibodies to neuronal membrane proteins such as the N-methyl-D-aspartate (NMDA) receptor are considered directly pathogenic based on disease models. Similar evidence exists for far fewer autoantibodies directed against intracellular targets. Attempts to produce an antibody-mediated animal model of human paraneoplastic disease have been unsuccessful to date. In this article, we review antineural antibodies and their clinical associations, briefly discuss recently characterized entities, and present proposed mechanisms of antibody pathogenicity.

Infection, Immunodeficiency, and Inflammatory Diseases in Autoimmune Neurology

2018 ◽  
Vol 38 (03) ◽  
pp. 379-391 ◽  
Author(s):  
Stacey Clardy ◽  
Amanda Piquet
Keyword(s):  
Differential Diagnosis ◽  
Immune System ◽  
Physical Examination ◽  
Neurological Disease ◽  
Viral Infections ◽  
Inflammatory Diseases ◽  
Critical Aspect ◽  
Immune Mediated ◽  
Comprehensive History

AbstractWhen patients present with neurological syndromes, such as encephalopathy/encephalitis, meningitis, and/or myelopathy/myelitis, the differential diagnosis is often broad, including infectious, inflammatory, autoimmune, vascular, and neoplastic etiologies. Just with inflammatory and autoimmune etiologies alone, there are numerous causative diseases. A comprehensive history and physical examination investigating for extraneurologic manifestations of immune-mediated disease is often necessary. Moreover, evaluating for an underlying infection and/or immunodeficiency becomes a critical aspect to the workup. This article will focus on the association of viral infections and dysregulation of the immune system as triggers of autoimmunity, in addition to various systemic inflammatory diseases that can cause neurological disease either with or without an established rheumatological disorder.

Immune-mediated experimental chronic pancreatitis

2001 ◽  
Vol 120 (5) ◽  
pp. A720-A720
Author(s):  
K RIACKEHEER ◽  
G SPARMANN ◽  
H KLEINE ◽  
H WEBER ◽  
S LIEBE ◽  
...  
Keyword(s):  
Chronic Pancreatitis ◽  
Immune Mediated ◽  
Experimental Chronic Pancreatitis

404: Immune Mediated Survival Advantage and Primary Tumor Control of Cryoablation Compared to Nephrectomy in a Murine Model of Advanced Renal Cancer

2006 ◽  
Vol 175 (4S) ◽  
pp. 132-132 ◽  
Author(s):  
Sean P. Hedican ◽  
Eric R. Wilkinson ◽  
Thomas F. Warner ◽  
Fred T. Lee ◽  
Stephen Y. Nakada
Keyword(s):  
Renal Cancer ◽  
Murine Model ◽  
Primary Tumor ◽  
Survival Advantage ◽  
Tumor Control ◽  
Advanced Renal Cancer ◽  
Immune Mediated

Abstract #1043 A Case of Immune-Mediated Hyperthyroidism Secondary to Atezolizumab Use

2018 ◽  
Vol 24 ◽  
pp. 240
Author(s):  
Zaib Khan ◽  
Khawla Ali ◽  
Carmen Polanco ◽  
Vinni Makin
Keyword(s):  
Immune Mediated

Investigating Neurological Disease

2001 ◽  
Author(s):  
Albert Hofman ◽  
Richard Mayeux
Keyword(s):  
Neurological Disease
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