Blending and Blend Uniformity

2016 ◽  
pp. 127-190 ◽  
Keyword(s):  
Blend Uniformity

Method transfer of a near-infrared spectroscopic method for blend uniformity in a poorly flowing and hygroscopic blend

2020 ◽  
Vol 180 ◽  
pp. 113054 ◽  
Author(s):  
Bárbara B. Alvarado-Hernández ◽  
James V. Scicolone ◽  
Carlos Ortega-Zuniga ◽  
Andrés D. Román-Ospino ◽  
Yleana M. Colón-Lugo ◽  
...  
Keyword(s):  
Near Infrared ◽  
Spectroscopic Method ◽  
Method Transfer ◽  
Blend Uniformity ◽  
Infrared Spectroscopic

scholarly journals STUDY OF DIRECT COMPRESSION METHOD FOR THE PREPARATION OF QUINAPRIL HYDROCHLORIDE TABLETS

2019 ◽  
pp. 202-211
Author(s):  
SHWETHA MARGRET JL ◽  
MADHAVI BLR
Keyword(s):  
Batch Size ◽  
In Vitro Dissolution ◽  
Content Uniformity ◽  
Compatibility Study ◽  
Direct Compression ◽  
Compression Method ◽  
Compression Technique ◽  
Blend Uniformity ◽  
Excipient Compatibility ◽  
Quinapril Hydrochloride

Objective: Direct compression method is preferable for tablet manufacture. The direct compression method is followed for many formulations but the relevant study is not reported. The present work aims to study the suitability of the direct compression process to prepare tablets of quinapril hydrochloride (QHCl), a low dose drug with a starting dose of 5 mg, indicated in the treatment of hypertension, congestive heart failure, and other conditions. Methods: QHCl is reported to be unstable in the presence of moisture, heat, and some excipients. The direct compression method was tried instead of a wet granulation technique to prepare the tablets. Initially, drug-excipient compatibility study was carried out. For selected excipients and QHCl preformulation tests were conducted. The stabilizer was employed. Three formulations were tried. The blends were prepared by tumbling and trituration methods. Blend uniformity and precompression parameters were determined. Tablets were directly compressed and evaluated. Results: Drug-excipient compatibility was studied at 60°C and 40°C with an Relative humidity (RH) of 75% for 4 weeks. It showed discoloration of the pure drug and most of the drug excipient mixtures. Three formulations Q1, Q2, and Q3 were prepared using magnesium oxide (light), magnesium carbonate (light), and Aerosil as stabilizers. Blending was done by trituration and tumbling method for 10 min and 15 min duration for the given batch size. Blend uniformity was determined. Tumbling method for 15 min showed good blending as evident from the percentage coefficient of variation values. The blends had a good flow. Tablet evaluation showed hardness in the range of 2.5–3 kg/cm2 and disintegration time of 1–2 min. Q1 and Q2 passed the friability test. The content uniformity criterion was achieved with an acceptance value <20. In vitro dissolution, Q1 and Q2 were 100% and 98.8%, respectively, in 30 min and followed first-order kinetics. The stability study of Q1 indicated a single peak in the chromatogram corresponding to the drug. Q2 showed spotted discoloration. Conclusion: The direct compression technique could be employed for the preparation of QHCl tablets. Q1 showed better stability and release characteristics. Q2 and Q3 are considered for further study.

Blend uniformity analysis of pharmaceutical products by Broadband Acoustic Resonance Dissolution Spectroscopy (BARDS)

2012 ◽  
Vol 438 (1-2) ◽  
pp. 134-139 ◽  
Author(s):  
Dara Fitzpatrick ◽  
Eoin Scanlon ◽  
Jacob Krüse ◽  
Bastiaan Vos ◽  
Rachel Evans-Hurson ◽  
...  
Keyword(s):  
Acoustic Resonance ◽  
Pharmaceutical Products ◽  
Blend Uniformity

Blend Uniformity of a Filament and Staple Composite Yarn and Its Effect on Dyeing

1998 ◽  
Vol 68 (7) ◽  
pp. 528-532 ◽  
Author(s):  
Ching-Iuan Su ◽  
Wen-Yean Wu ◽  
Jiunn-Yih Lee
Keyword(s):  
Composite Yarn ◽  
Blend Uniformity

Blend uniformity and powder phenomena inside the continuous tumble mixer using DEM simulations

AIChE Journal ◽  
2014 ◽  
Vol 61 (3) ◽  
pp. 792-801 ◽  
Author(s):  
Miguel Florian-Algarin ◽  
Rafael Méndez
Keyword(s):  
Dem Simulations ◽  
Blend Uniformity
Sign in / Sign up

Export Citation Format

Share Document