Modelling Studies of the Roll and the Pitch Training Ship

2013 ◽  
pp. 299-302
Author(s):  
W Mironiuk ◽  
A Pawl_dzio
Keyword(s):  
Modelling Studies

A Study of the Average Flow in Open Channel with Baffle Blocks Distributed Uniformly

10.29007/zx1w ◽  
2018 ◽  
Author(s):  
Dung Tien Tran ◽  
Anh Tuan Le ◽  
Hong Nhung Le ◽  
Viet Hung Ho
Keyword(s):  
Water Level ◽  
Water Depth ◽  
Open Channel ◽  
Block Size ◽  
Average Flow ◽  
Modelling Studies ◽  
Baffle Block

A study of average flow in open channel with baffle blocks distributed uniformly has been considered by using channel with varied slopes. In this article, experimental and modelling studies were introduced when the correlation between the water depth and baffle block size is significant. The objective of the work is to give the rudimentary relations between discharge and water level in the channels. When the water depth is large, the effect of bottom channel friction on the flow is relatively small. This paper also gives applications of the software ‘Telemac-2D’ to simulate the flow under different conditions.

Synthesis of Indolyl Pyrazole Scaffolds as Potential Anti-cancer Agents and their Molecular Modelling Studies

2020 ◽  
Vol 17 (7) ◽  
pp. 828-839
Author(s):  
Ganga Reddy Gaddam ◽  
Pramod Kumar Dubey ◽  
Venkata Ramana Reddy Chittireddy
Keyword(s):  
Cell Lines ◽  
Biological Activities ◽  
Moderate Activity ◽  
Lung Cancer Cell ◽  
Anti Cancer ◽  
A549 Lung Cancer Cell ◽  
New Chemical Entities ◽  
Molecular Modelling Studies ◽  
Modelling Studies ◽  
A549 Lung

Background:: Indole and pyrazoles are one of the prime structural units in the field of medicinal chemistry and have been reported to exhibit a variety of biological activities specifically anti-cancer. In view of their medicinal significance, we synthesized a conjugate of the two moieties to get access to newer and potential anti-cancer agents. Methods: Indolyl pyrazoles [3-(1,3-diphenyl-1H-pyrazol-4-yl)-2-(1-methyl-1H-indole-3-carbon yl)acrylonitriles] (4a-l) were synthesized by adopting simple and greener protocol and all the synthesized derivatives were docked against Bcl-2 protein and the selected chemical moieties were screened for their cytotoxicity by using the MTT assay. Results: : All the synthesized compounds were docked against BCL-2 protein in order to understand their binding pattern. Among the 12 compounds docked, 4d, 4f, 4h, 4j, and 4l compounds exhibited better protein binding interactions and the same were screened for their anti-cancer activity against A549 (lung) cancer cell lines at a concentration of 100 μM using Doxorubicin as standard. Substitutions such as N-benzyl, N-ethyl groups and halogen groups such as Br, Cl on indole ring showed moderate activity against A-549 cell lines. Conclusion:: Among the 5 indolyl pyrazole derivatives screened, compounds 4h and 4j showed significantly better activity with an IC50 of 33.12 and 34.24 μM, respectively. Further, structural tweaking of the synthesized new chemical entities may lead to potential hit/lead-like molecules.

scholarly journals A synthesis of three decades of hydrological research at Scotty Creek, NWT, Canada

2019 ◽  
Vol 23 (4) ◽  
pp. 2015-2039 ◽  
Author(s):  
William Quinton ◽  
Aaron Berg ◽  
Michael Braverman ◽  
Olivia Carpino ◽  
Laura Chasmer ◽  
...  
Keyword(s):  
Land Cover ◽  
Water Flux ◽  
Study Region ◽  
Physical Mechanisms ◽  
Permafrost Thaw ◽  
Discontinuous Permafrost ◽  
Modelling Studies ◽  
Hydrology And Water Resources ◽  
And Storage ◽  
Storage Processes

Abstract. Scotty Creek, Northwest Territories (NWT), Canada, has been the focus of hydrological research for nearly three decades. Over this period, field and modelling studies have generated new insights into the thermal and physical mechanisms governing the flux and storage of water in the wetland-dominated regions of discontinuous permafrost that characterises much of the Canadian and circumpolar subarctic. Research at Scotty Creek has coincided with a period of unprecedented climate warming, permafrost thaw, and resulting land cover transformations including the expansion of wetland areas and loss of forests. This paper (1) synthesises field and modelling studies at Scotty Creek, (2) highlights the key insights of these studies on the major water flux and storage processes operating within and between the major land cover types, and (3) provides insights into the rate and pattern of the permafrost-thaw-induced land cover change and how such changes will affect the hydrology and water resources of the study region.

Functional and modelling studies of the binding of human monoclonal anti-DNA antibodies to DNA

1996 ◽  
Vol 33 (4-5) ◽  
pp. 471-483 ◽  
Author(s):  
Jatinderpal K. Kalsi ◽  
Andrew C.R. Martin ◽  
Yasuhiko Hirabayashi ◽  
Michael Ehrenstein ◽  
Celia M. Longhurst ◽  
...  
Keyword(s):  
Modelling Studies ◽  
Dna Antibodies ◽  
Antibodies To Dna

scholarly journals Comparing two sequential Monte Carlo samplers for exact and approximate Bayesian inference on biological models

2017 ◽  
Vol 14 (134) ◽  
pp. 20170340 ◽  
Author(s):  
Aidan C. Daly ◽  
Jonathan Cooper ◽  
David J. Gavaghan ◽  
Chris Holmes
Keyword(s):  
Bayesian Inference ◽  
Bayesian Methods ◽  
Sequential Monte Carlo ◽  
Model Parameters ◽  
Biological Models ◽  
Exact Inference ◽  
Modelling Studies ◽  
Approximate Bayesian ◽  
Approximate Bayesian Inference ◽  
Abc Methods

Bayesian methods are advantageous for biological modelling studies due to their ability to quantify and characterize posterior variability in model parameters. When Bayesian methods cannot be applied, due either to non-determinism in the model or limitations on system observability, approximate Bayesian computation (ABC) methods can be used to similar effect, despite producing inflated estimates of the true posterior variance. Owing to generally differing application domains, there are few studies comparing Bayesian and ABC methods, and thus there is little understanding of the properties and magnitude of this uncertainty inflation. To address this problem, we present two popular strategies for ABC sampling that we have adapted to perform exact Bayesian inference, and compare them on several model problems. We find that one sampler was impractical for exact inference due to its sensitivity to a key normalizing constant, and additionally highlight sensitivities of both samplers to various algorithmic parameters and model conditions. We conclude with a study of the O'Hara–Rudy cardiac action potential model to quantify the uncertainty amplification resulting from employing ABC using a set of clinically relevant biomarkers. We hope that this work serves to guide the implementation and comparative assessment of Bayesian and ABC sampling techniques in biological models.

scholarly journals Implementation Strategies for Improving Vitamin D Status and Increasing Vitamin D Intake in the UK: Current Controversies and Future Perspectives. Proceedings of the 2nd Rank Prize Funds Forum on Vitamin D

2021 ◽  
pp. 1-60
Author(s):  
J.L. Buttriss ◽  
S.A. Lanham-New ◽  
S. Steenson ◽  
L. Levy ◽  
G.E. Swan ◽  
...  
Keyword(s):  
Vitamin D ◽  
Age Groups ◽  
Implementation Strategies ◽  
Vitamin D Status ◽  
Cost Information ◽  
Hydroxyvitamin D ◽  
Minority Ethnic Groups ◽  
Modelling Studies ◽  
Clinical Consequences ◽  
The Uk

Abstract A multi-disciplinary expert group met to discuss vitamin D deficiency in the UK, and strategies for improving population intakes and status. Changes to UK Government advice since the 1st Rank Forum on Vitamin D (2009) were discussed, including rationale for setting a RNI (10µg/day;400IU/day) for adults and children (4+ years). Current UK data show inadequate intakes among all age groups, and high prevalence of low vitamin D status among specific groups (e.g. pregnant women and adolescent males/females). Evidence of widespread deficiency within some minority ethnic groups, resulting in nutritional rickets (particularly among Black and South Asian infants), raised particular concern. It is too early to establish whether population vitamin D status has altered since Government recommendations changed in 2016. Vitamin D food fortification was discussed as a potential strategy to increase population intakes. Data from dose-response and dietary modelling studies indicate dairy products, bread, hens’ eggs and some meats as potential fortification vehicles. Vitamin D3 appears more effective than vitamin D2 for raising serum 25-hydroxyvitamin D concentration, which has implications for choice of fortificant. Other considerations for successful fortification strategies include: i) need for ‘real-world’ cost information for use in modelling work; ii) supportive food legislation; iii) improved consumer and health professional understanding of vitamin D’s importance; iv) clinical consequences of inadequate vitamin D status; v) consistent communication of Government advice across health/social care professions, and via the food industry. These areas urgently require further research to enable universal improvement in vitamin D intakes and status in the UK population.

Adsorption of Eu(III) at rutile/water interface: Batch, spectroscopic and modelling studies

2021 ◽  
Vol 611 ◽  
pp. 125811
Author(s):  
Wanqiang Zhou ◽  
Yanlin Shi ◽  
Yao Li ◽  
Dongfan Xian ◽  
Jingyi Wang ◽  
...  
Keyword(s):  
Water Interface ◽  
Modelling Studies
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