Hepatitis B: a case study in MCMC methods

1995 ◽  
pp. 39-62
Keyword(s):  
Hepatitis B ◽  
Mcmc Methods

Hepatitis B: A Case Study in MCMC

1998 ◽  
pp. 575-598
Author(s):  
D. J. Spiegelhalter ◽  
N. G. Best ◽  
W. R. Gilks ◽  
H. Inskip
Keyword(s):  
Hepatitis B

scholarly journals Toolbox for Non-Intrusive Structural and Functional Analysis of Recombinant VLP Based Vaccines: A Case Study with Hepatitis B Vaccine

PLoS ONE ◽  
2012 ◽  
Vol 7 (4) ◽  
pp. e33235 ◽  
Author(s):  
Anke M. Mulder ◽  
Bridget Carragher ◽  
Victoria Towne ◽  
Yuan Meng ◽  
Yang Wang ◽  
...  
Keyword(s):  
Functional Analysis ◽  
Hepatitis B ◽  
Hepatitis B Vaccine

Practical Use of MCMC Methods: Lessons from a Case Study

2002 ◽  
Vol 44 (4) ◽  
pp. 433 ◽  
Author(s):  
Grietje Zuur ◽  
Paul H. Garthwaite ◽  
Rob J. Fryer
Keyword(s):  
Mcmc Methods

scholarly journals Coevolution analysis of amino-acids reveals diversified drug-resistance solutions in viral sequences: a case study of hepatitis B virus

2020 ◽  
Vol 6 (1) ◽  
Author(s):  
Elin Teppa ◽  
Francesca Nadalin ◽  
Christophe Combet ◽  
Diego Javier Zea ◽  
Laurent David ◽  
...  
Keyword(s):  
Drug Resistance ◽  
Hepatitis B Virus ◽  
Hepatitis B ◽  
Resistance Mutations ◽  
Drug Resistance Mutations ◽  
Coevolution Analysis ◽  
B Virus ◽  
Compensatory Mutations ◽  
Viral Sequences

Abstract The study of mutational landscapes of viral proteins is fundamental for the understanding of the mechanisms of cross-resistance to drugs and the design of effective therapeutic strategies based on several drugs. Antiviral therapy with nucleos(t)ide analogues targeting the hepatitis B virus (HBV) polymerase protein (Pol) can inhibit disease progression by suppression of HBV replication and makes it an important case study. In HBV, treatment may fail due to the emergence of drug-resistant mutants. Primary and compensatory mutations have been associated with lamivudine resistance, whereas more complex mutational patterns are responsible for resistance to other HBV antiviral drugs. So far, all known drug-resistance mutations are located in one of the four Pol domains, called reverse transcriptase. We demonstrate that sequence covariation identifies drug-resistance mutations in viral sequences. A new algorithmic strategy, BIS2TreeAnalyzer, is designed to apply the coevolution analysis method BIS2, successfully used in the past on small sets of conserved sequences, to large sets of evolutionary related sequences. When applied to HBV, BIS2TreeAnalyzer highlights diversified viral solutions by discovering thirty-seven positions coevolving with residues known to be associated with drug resistance and located on the four Pol domains. These results suggest a sequential mechanism of emergence for some mutational patterns. They reveal complex combinations of positions involved in HBV drug resistance and contribute with new information to the landscape of HBV evolutionary solutions. The computational approach is general and can be applied to other viral sequences when compensatory mutations are presumed.

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