Altered Development of the Pulmonary Circulation in Chronic Lung Injury

1999 ◽  
pp. 620-641
Keyword(s):  
Lung Injury ◽  
Pulmonary Circulation

Downregulation of blood and bone marrow neutrophils decreases expression of acute lung injury in sheep

1992 ◽  
Vol 263 (5) ◽  
pp. H1492-H1498
Author(s):  
P. J. McKenna ◽  
D. L. Rosolia ◽  
Y. Ishihara ◽  
K. H. Albertine ◽  
N. C. Staub ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Acute Lung Injury ◽  
Lung Injury ◽  
Peripheral Blood ◽  
Pulmonary Circulation ◽  
Tissue Injury ◽  
Blood Neutrophils ◽  
Superoxide Release

We have shown that infusion of zymosan-activated plasma (ZAP) in sheep causes acute lung injury and downregulates peripheral blood neutrophils in that elicited superoxide release is reduced for at least 24 h after the infusion. The present study was designed to test the following hypotheses: 1) peripheral blood neutrophils are representative of neutrophils marginated in the pulmonary circulation, 2) blood neutrophils are downregulated because neutrophils developing in bone marrow are similarly affected, and 3) downregulated neutrophils have a reduced capacity to produce tissue injury. In a series of experiments in 21 sheep, we showed that elicited superoxide release was similar in peripheral blood neutrophils and in marginated neutrophils washed out of the pulmonary vascular bed. Measurements of superoxide release from blood and bone marrow neutrophils collected 2-24 h after ZAP infusion revealed progressive downregulation with time and greater downregulation of superoxide release in bone marrow neutrophils compared with peripheral blood neutrophils. Finally, after downregulating peripheral blood neutrophils, subsequent infusion of ZAP in conscious sheep produced sequestration of neutrophils in the pulmonary circulation but failed to produce a sustained increase in lung lymph protein clearance. The results suggest that neutrophil downregulation, as measured in vitro, is expressed in vivo as reduced ability of neutrophils to produce tissue injury when challenged by an activating agent.

Regulation of the Pulmonary Circulation During Lung Injury

1992 ◽  
pp. 87-92
Author(s):  
N. F. Voelkel ◽  
S. Chang ◽  
T. McDonnell ◽  
C. Chen ◽  
J. Czartolomna
Keyword(s):  
Lung Injury ◽  
Pulmonary Circulation

scholarly journals Pulmonary Circulation in Acute Lung Injury in the Presence of Acute Poisoning by Toxic Substances

2007 ◽  
Vol 3 (3) ◽  
pp. 23
Author(s):  
A. N. Lodyagin ◽  
G. A. Livanov ◽  
I. P. Nikolayeva ◽  
B. V. Batotsyrenov ◽  
G. V. Shestova
Keyword(s):  
Acute Lung Injury ◽  
Lung Injury ◽  
Pulmonary Circulation ◽  
Acute Poisoning ◽  
Toxic Substances

scholarly journals Chronic Lung Injury in Preterm Lambs: Abnormalities of the Pulmonary Circulation and Lung Fluid Balance

2000 ◽  
Vol 48 (1) ◽  
pp. 64-74 ◽  
Author(s):  
Richard D Bland ◽  
Kurt H Albertine ◽  
David P Carlton ◽  
Linda Kullama ◽  
Penny Davis ◽  
...  
Keyword(s):  
Lung Injury ◽  
Fluid Balance ◽  
Pulmonary Circulation ◽  
Lung Fluid ◽  
Lung Fluid Balance
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