Roles for NAD(P)H Oxidases as Vascular Oxygen Sensors and Their Influence on Oxidant-Regulated Signaling Mechanisms

2003 ◽  
pp. 595-607 ◽  
Keyword(s):  
Oxygen Sensors ◽  
Signaling Mechanisms

Genetic Dissection of PTEN Signaling Mechanisms in Prostate Cancer

2005 ◽  
Author(s):  
Megan E. Keniry ◽  
Greg Hannon ◽  
Ramon Parsons
Keyword(s):  
Prostate Cancer ◽  
Genetic Dissection ◽  
Signaling Mechanisms

Tuning Down the Pain – An Overview of Allosteric Modulation of Opioid Receptors: Mechanisms of Modulation, Allosteric Sites, Modulator Syntheses

2020 ◽  
Vol 20 (31) ◽  
pp. 2852-2865 ◽  
Author(s):  
Damian Bartuzi ◽  
Tomasz M. Wróbel ◽  
Agnieszka A. Kaczor ◽  
Dariusz Matosiuk
Keyword(s):  
Side Effects ◽  
Opioid Receptors ◽  
Pain Perception ◽  
Allosteric Modulation ◽  
Allosteric Modulators ◽  
Signaling Mechanisms ◽  
Main Target ◽  
Allosteric Sites ◽  
Biased Signaling ◽  
Opioid Signaling

Opioid signaling plays a central role in pain perception. As such, it remains the main target in the development of antinociceptive agents, despite serious side effects involved. In recent years, hopes for improved opioid painkillers are rising, together with our understanding of allosterism and biased signaling mechanisms. In this review, we focus on recently discovered allosteric modulators of opioid receptors, insights into phenomena underlying their action, as well as on how they extend our understanding of mechanisms of previously known compounds. A brief overlook of their synthesis is also presented.

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