Calcium and Vitamin D: Regulation of Mineral Homeostasis

2006 ◽  
pp. 45-53
Author(s):  
D Goltzman
Keyword(s):  
Vitamin D ◽  
Mineral Homeostasis

scholarly journals Transcriptional responses in jejunum of two layer chicken strains following variations in dietary calcium and phosphorus levels

BMC Genomics ◽  
2021 ◽  
Vol 22 (1) ◽  
Author(s):  
Henry Reyer ◽  
Michael Oster ◽  
Siriluck Ponsuksili ◽  
Nares Trakooljul ◽  
Adewunmi O. Omotoso ◽  
...  
Keyword(s):  
Vitamin D ◽  
High Performance ◽  
Absorption Capacity ◽  
Egg Laying ◽  
Endocrine Regulation ◽  
Transcriptional Responses ◽  
Endogenous Factors ◽  
Mineral Homeostasis ◽  
Laying Performance ◽  
Vitamin D Levels

Abstract Background Calcium (Ca) and phosphorus (P) are essential nutrients that are linked to a large array of biological processes. Disturbances in Ca and P homeostasis in chickens are associated with a decline in growth and egg laying performance and environmental burden due to excessive P excretion rates. Improved utilization of minerals in particular of P sources contributes to healthy growth while preserving the finite resource of mineral P and mitigating environmental pollution. In the current study, high performance Lohmann Selected Leghorn (LSL) and Lohmann Brown (LB) hens at peak laying performance were examined to approximate the consequences of variable dietary Ca and P supply. The experimental design comprised four dietary groups with standard or reduced levels of either Ca or P or both (n = 10 birds per treatment group and strain) in order to stimulate intrinsic mechanisms to maintain homeostasis. Jejunal transcriptome profiles and the systemic endocrine regulation of mineral homeostasis were assessed (n = 80). Results Endogenous mechanisms to maintain mineral homeostasis in response to variations in the supply of Ca and P were effective in both laying hen strains. However, the LSL and LB appeared to adopt different molecular pathways, as shown by circulating vitamin D levels and strain-specific transcriptome patterns. Responses in LSL indicated altered proliferation rates of intestinal cells as well as adaptive responses at the level of paracellular transport and immunocompetence. Endogenous mechanisms in LB appeared to involve a restructuring of the epithelium, which may allow adaptation of absorption capacity via improved micro-anatomical characteristics. Conclusions The results suggest that LSL and LB hens may exhibit different Ca, P, and vitamin D requirements, which have so far been neglected in the supply recommendations. There is a demand for trial data showing the mechanisms of endogenous factors of Ca and P homeostasis, such as vitamin D, at local and systemic levels in laying hens.

Vitamin D and Bone Mineral Homeostasis during Pregnancy in the Diabetic BB Rat*

Endocrinology ◽  
1986 ◽  
Vol 118 (3) ◽  
pp. 1019-1025 ◽  
Author(s):  
JOHAN VERHAEGHE ◽  
ROGER BOUILLON ◽  
BULANGU L. NYOMBA ◽  
WILLY LISSENS ◽  
F. ANDRÉ VAN ASSCHE
Keyword(s):  
Vitamin D ◽  
Bone Mineral ◽  
Bb Rat ◽  
Mineral Homeostasis

scholarly journals Comparison of the Pharmacological Effects of Paricalcitol and Doxercalciferol on the Factors Involved in Mineral Homeostasis

2010 ◽  
Vol 2010 ◽  
pp. 1-8 ◽  
Author(s):  
J. Ruth Wu-Wong ◽  
Masaki Nakane ◽  
Gerard D. Gagne ◽  
Kristin A. Brooks ◽  
William T. Noonan
Keyword(s):  
Vitamin D ◽  
Cell Proliferation ◽  
Mrna Expression ◽  
Active Form ◽  
Parathyroid Cell ◽  
Pharmacological Effects ◽  
Sprague Dawley ◽  
Mineral Homeostasis ◽  
Sprague Dawley Rats ◽  
Serum Pth

Vitamin D receptor agonists (VDRAs) directly suppress parathyroid hormone (PTH) mRNA expression. Different VDRAs are known to have differential effects on serum calcium (Ca), which may also affect serum PTH levels since serum Ca regulates PTH secretion mediated by the Ca-sensing receptor (CaSR). In this study, we compared the effects of paricalcitol and doxercalciferol on regulating serum Ca and PTH, and also the expression of PTH, VDR, and CaSR mRNA. The 5/6 nephrectomized (NX) Sprague-Dawley rats on a normal or hyperphosphatemia-inducing diet were treated with vehicle, paricalcitol, or doxercalciferol for two weeks. Both drugs at the tested doses (0.042–0.33 g/kg) suppressed PTH mRNA expression and serum PTH effectively in the 5/6 NX rats, but paricalcitol was less potent in raising serum Ca than doxercalciferol. In pig parathyroid cells, paricalcitol and the active form of doxercalciferol induced VDR translocation from the cytoplasm into the nucleus, suppressed PTH mRNA expression and inhibited cell proliferation in a similar manner, although paricalcitol induced the expression of CaSR mRNA more effectively. The multiple effects of VDRAs on modulating serum Ca, parathyroid cell proliferation, and the expression of CaSR and PTH mRNA reflect the complex involvement of the vitamin D axis in regulating the mineral homeostasis system.

Early Oral Administration of Vitamin D and its Metabolites in Premature Neonates. Effect on Mineral Homeostasis

1982 ◽  
Vol 16 (Supplement) ◽  
pp. 75???78 ◽  
Author(s):  
BERNARD L. SALLE ◽  
LOUIS DAVID ◽  
F. H. GLORIEUX ◽  
E. DELVIN ◽  
JACQUES SENTERE ◽  
...  
Keyword(s):  
Vitamin D ◽  
Oral Administration ◽  
Premature Neonates ◽  
Mineral Homeostasis

Cross-Sectional Analysis of Abnormalities of Mineral Homeostasis, Vitamin D and Parathyroid Hormone in a Cohort of Pre-Dialysis Patients

2007 ◽  
Vol 107 (3) ◽  
pp. c109-c116 ◽  
Author(s):  
Daniel Zehnder ◽  
Martin J. Landray ◽  
David C. Wheeler ◽  
William Fraser ◽  
Lisa Blackwell ◽  
...  
Keyword(s):  
Vitamin D ◽  
Parathyroid Hormone ◽  
Dialysis Patients ◽  
Cross Sectional ◽  
Mineral Homeostasis ◽  
Cross Sectional Analysis ◽  
Sectional Analysis

scholarly journals Genomic Mechanisms Governing Mineral Homeostasis and the Regulation and Maintenance of Vitamin D Metabolism

JBMR Plus ◽  
2020 ◽  
Author(s):  
J Wesley Pike ◽  
Seong Min Lee ◽  
Nancy A Benkusky ◽  
Mark B Meyer
Keyword(s):  
Vitamin D ◽  
Vitamin D Metabolism ◽  
Mineral Homeostasis
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