Histology and immunohistochemical studies of female genital tissue

2005 ◽  
pp. 125-133 ◽  
Author(s):  
Emmanuele Jannini ◽  
Giulia d’Amati ◽  
Andrea Lenzi
2020 ◽  
Vol 83 (5) ◽  
Author(s):  
Kevin A. Stoner ◽  
May A. Beamer ◽  
Hilary A. Avolia ◽  
Leslie A. Meyn ◽  
Sharon L. Hillier ◽  
...  

1995 ◽  
Vol 39 (8) ◽  
pp. 1899-1901 ◽  
Author(s):  
P. M. Furneri ◽  
A. Cianci ◽  
L. Campo ◽  
L. S. Roccasalva ◽  
G. Tempera ◽  
...  

1998 ◽  
Vol 66 (2) ◽  
pp. 514-520 ◽  
Author(s):  
Eva-Liz Johansson ◽  
Carola Rask ◽  
Margareta Fredriksson ◽  
Kristina Eriksson ◽  
Cecil Czerkinsky ◽  
...  

ABSTRACT We studied the antibody response including antibody-secreting cells (ASC) in the female genital tract of mice after mucosal immunizations with the recombinant B subunit of cholera toxin (rCTB) perorally, intraperitoneally, vaginally, and intranasally (i.n.). The strongest genital antibody responses as measured with a novel perfusion-extraction method were induced after vaginal and i.n. immunizations, and these routes also gave rise to specific immunoglobulin A (IgA) and IgG ASC in the genital mucosa. Specific ASC in the iliac lymph nodes, which drain the female genital tract, were seen only after vaginal immunization. Progesterone treatment increased the ASC response in the genital tissue after all mucosal immunizations but most markedly after vaginal immunization. We also tested rCTB as a carrier for human gamma globulin (HGG) and the effect of adding cholera toxin (CT) as an adjuvant for the induction of systemic and genital antibody responses to HGG after vaginal and i.n. immunizations. Vaginal immunizations with HGG conjugated to rCTB resulted in high levels of genital anti-HGG antibodies whether or not CT was added, while after i.n. immunization the strongest antibody response was seen with the conjugate together with CT. In summary, vaginal and i.n. immunization give rise to a specific mucosal immune response including ASC in the genital tissue, and vaginal immunization also elicits ASC in the iliac lymph nodes. We have also shown that rCTB can act as an efficient carrier for a conjugated antigen for induction of a specific antibody response in the genital tract of mice after vaginal or i.n. immunization.


Author(s):  
B. L. Soloff ◽  
A. L. Barron ◽  
H. J. White ◽  
R. G. Rank

Chlamydial organisms (specifically C. trachomatis) have been implicated as a frequent cause of genital infection in the human (1). Study of the histo- pathological aspects of such infections has been impeded because of difficulties in obtaining adequate tissue specimens and the lack of a suitable experimental host. In 1964, Murray (2) isolated the causative agent of guinea pig inclusion conjunctivitis which possesses similarities to human inclusion conjunctivitis. This guinea pig organism was found to be a member of the Chlamydia psittaci subgroup and was designated as the Gp-ic agent. Male guinea pigs have been successfully infected with Gp-ic by intraurethral inoculation. Transmission of the infection to the female by sexual contact has been demonstrated (3). We are not aware of any ultrastructural studies to date concerning the development of this agent in genital tissue.Studies in our laboratory have established that, in our guinea pig model, the cervix is the major site of injection.


1998 ◽  
Vol 5 (1) ◽  
pp. 94A-94A
Author(s):  
R MIXON ◽  
R BRISSIE ◽  
W GRIZZLE ◽  
J THOMAS ◽  
O FAYEPELERSEN ◽  
...  

2006 ◽  
Vol 39 (2) ◽  
pp. 16
Author(s):  
NAWAL M. NOUR

1991 ◽  
Vol 53 (2) ◽  
pp. 259-262
Author(s):  
Itaru TOKUHASHI ◽  
Masayuki MURAKAMI ◽  
Koji SERIKAWA ◽  
Hidemi SUZUKI ◽  
Mitsuhiro SATO ◽  
...  

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