Choroidal neovascularization: VEGF pathways

Myopic choroidal neovascularization and OCT angiography

Minerva Oftalmologica ◽

10.23736/s0026-4903.18.01805-6 ◽

2018 ◽

Vol 60 (3) ◽

Author(s):

Alfredo Pece

Keyword(s):

Choroidal Neovascularization ◽

Oct Angiography ◽

Myopic Choroidal Neovascularization

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The efficacy of anti-VEGF therapy in patients with bilateral myopic choroidal neovascularization depending on the time of treatment (clinical case)

Modern technologies in ophtalmology ◽

10.25276/2312-4911-2019-1-277-280 ◽

2019 ◽

pp. 277-280

Author(s):

N.V. Zaitseva ◽

◽

T.N. Iureva ◽

A.P. Yakimov ◽

◽

...

Keyword(s):

Choroidal Neovascularization ◽

Clinical Case ◽

Myopic Choroidal Neovascularization ◽

Anti Vegf

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Functional parameters of patients with central serous chorioretinopathy complicated by choroidal neovascularization on the background of antiangiogenic therapy

POINT OF VIEW EAST – WEST ◽

10.25276/2410-1257-2020-2-40-42 ◽

2020 ◽

pp. 40-42

Author(s):

A.A. Plyukhova ◽

◽

M.A. Afanasyeva ◽

Keyword(s):

Choroidal Neovascularization ◽

Central Serous Chorioretinopathy ◽

Antiangiogenic Therapy ◽

Functional Parameters

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Choroidal Neovascularization Associated with Morning Glory Syndrome: A Case Report

Archives of Clinical and Medical Case Reports ◽

10.26502/acmcr.96550293 ◽

2020 ◽

Vol 04 (06) ◽

Author(s):

Shigeru Sato ◽

Takeshi Morimoto ◽

Sayaka Tanaka ◽

Motokazu Tsujikawa ◽

Kohji Nishida

Keyword(s):

Case Report ◽

Choroidal Neovascularization ◽

Morning Glory ◽

Morning Glory Syndrome

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Faculty Opinions recommendation of Randomized trial of a home monitoring system for early detection of choroidal neovascularization home monitoring of the Eye (HOME) study.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.718170898.793489994 ◽

2014 ◽

Author(s):

Carl Regillo ◽

SK Steven Houston III

Keyword(s):

Early Detection ◽

Randomized Trial ◽

Choroidal Neovascularization ◽

Monitoring System ◽

Home Monitoring ◽

Home Study

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Faculty Opinions recommendation of Gut microbiota influences pathological angiogenesis in obesity-driven choroidal neovascularization.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.726996915.793529230 ◽

2017 ◽

Author(s):

Christiana Ruhrberg ◽

Alessandro Fantin

Keyword(s):

Gut Microbiota ◽

Choroidal Neovascularization ◽

Pathological Angiogenesis

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Faculty Opinions recommendation of Bevacizumab vs photodynamic therapy for choroidal neovascularization in multifocal choroiditis.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.9579956.10240054 ◽

2011 ◽

Author(s):

Chi-Chao Chan ◽

Hatice Nida Sen

Keyword(s):

Photodynamic Therapy ◽

Choroidal Neovascularization ◽

Multifocal Choroiditis

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Topical Diclofenac-Loaded Liposomes Ameliorate Laser-Induced Choroidal Neovascularization in Mice and Non-Human Primates

Current Neurovascular Research ◽

10.2174/1567202614666161104115440 ◽

2017 ◽

Vol 14 (1) ◽

pp. 46-52 ◽

Cited By ~ 3

Author(s):

Masamitsu Shimazawa ◽

Yuki Inoue ◽

Tomomi Masuda ◽

Risako Onodera ◽

Kohei Tahara ◽

...

Keyword(s):

Choroidal Neovascularization ◽

Topical Diclofenac

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Anti-VEGFR2 Antibody-modified Micelle for Triggered Drug Delivery and Effective Therapy of Choroidal Neovascularization

Current Neurovascular Research ◽

10.2174/1567202616666190619150956 ◽

2019 ◽

Vol 16 (3) ◽

pp. 258-265

Author(s):

Kei Takahashi ◽

Tomomi Masuda ◽

Mitsunori Harada ◽

Tadashi Inoue ◽

Shinsuke Nakamura ◽

...

Keyword(s):

Drug Delivery ◽

Choroidal Neovascularization ◽

Pigment Epithelium ◽

Drug Carrier ◽

Retinal Pigment ◽

Laser Coagulation ◽

Antiangiogenic Agents ◽

Drug Carrier System ◽

Novel Drug ◽

Drug Delivery Devices

Objective: This study aimed to examine whether DC101 (anti-VEGFR2 antibody)- modified micelles have applications as novel drug delivery devices, which allow small molecule antiangiogenic agents to deliver to angiogenic sites on a murine laser-induced choroidal neovascularization (CNV) model. Materials and Method: CNV was induced by photocoagulation on the unilateral eye of each mouse under anesthesia. Immediately after laser coagulation, E7974-loaded DC101-modified micelles and motesanib-loaded DC101-modified micelles were intravitreally administrated. Two weeks after photocoagulation, CNV was visualized using fluorescein-conjugated dextran (MW=2,000 kDa), and the CNV area was measured in retinal pigment epithelium (RPE)-choroidal flat mounts. Results: Intravitreal administration of both DC101-modified micelles loaded with E7974 at 2 µM and motesanib at 2 µM significantly reduced CNV area in the murine laser-induced CNV model at a clearly lower concentration than the effective dose of each agent. Conclusion: These results suggest that DC101-modified micelle might be effective drug carrier system for treating CNV and other ocular angiogenic diseases.

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