Childhood adversity, monoamine oxidase A genotype and risk for conduct disorder

2006 ◽  
pp. 67-78
Author(s):  
Brien Riley
Keyword(s):  
Monoamine Oxidase ◽  
Conduct Disorder ◽  
Childhood Adversity ◽  
Monoamine Oxidase A

scholarly journals Monoamine oxidase A and childhood adversity as risk factors for conduct disorder in females

2008 ◽  
Vol 39 (4) ◽  
pp. 579-590 ◽  
Author(s):  
E. C. Prom-Wormley ◽  
L. J. Eaves ◽  
D. L. Foley ◽  
C. O. Gardner ◽  
K. J. Archer ◽  
...  
Keyword(s):  
Monoamine Oxidase ◽  
Conduct Disorder ◽  
Childhood Adversity ◽  
Monoamine Oxidase A ◽  
Environment Interaction ◽  
Linked Gene ◽  
Genotype Environment Interaction ◽  
Gene Environment ◽  
Main Effect ◽  
Low Activity

BackgroundRecent studies among males have reported a genotype–environment interaction (G×E) in which low-activity alleles at the monoamine oxidase A (MAOA) locus conferred greater sensitivity to the effects of childhood adversity on risk for conduct disorder (CD). So far, few studies of females have controlled for gene–environment correlation or used females heterozygous for this X-linked gene.MethodLogistic regression analysis of a sample of 721 females ages 8–17 years from the longitudinal Virginia Twin Study of Adolescent Behavioral Development (VTSABD) assessed the additive effects of MAOA genotypes on risk for CD, together with the main effect of childhood adversity and parental antisocial personality disorder (ASP), as well as the interaction of MAOA with childhood adversity on risk for CD.ResultsA significant main effect of genotype on risk for CD was detected, where low-activity MAOA imparted the greatest risk to CD in girls while controlling for the significant effects of maternal ASP and childhood adversity. Significant G×E with weak effect was detected when environmental exposure was untransformed, indicating a higher sensitivity to childhood adversity in the presence of the high-activity MAOA allele. The interaction was no longer statistically significant after applying a ridit transformation to reflect the sample sizes exposed at each level of childhood adversity.ConclusionsThe main effect of MAOA on risk for CD in females, its absence in males and directional difference of interaction is suggestive of genotype–sex interaction. As the effect of G×E on risk for CD was weak, its inclusion is not justified.

Monoamine oxidase A genotype, childhood adversity, and criminal behavior in an incarcerated sample

2014 ◽  
Vol 24 (4) ◽  
pp. 164-171 ◽  
Author(s):  
Todd A. Armstrong ◽  
Brian B. Boutwell ◽  
Shahida Flores ◽  
Mary Symonds ◽  
Shawn Keller ◽  
...  
Keyword(s):  
Monoamine Oxidase ◽  
Criminal Behavior ◽  
Childhood Adversity ◽  
Monoamine Oxidase A

scholarly journals Childhood Adversity, Monoamine Oxidase A Genotype, and Risk for ConductDisorder

2004 ◽  
Vol 61 (7) ◽  
pp. 738 ◽  
Author(s):  
Debra L. Foley ◽  
Lindon J. Eaves ◽  
Brandon Wormley ◽  
Judy L. Silberg ◽  
Hermine H. Maes ◽  
...  
Keyword(s):  
Monoamine Oxidase ◽  
Childhood Adversity ◽  
Monoamine Oxidase A

scholarly journals High-dose testosterone treatment reduces monoamine oxidase A levels in the human brain: a preliminary report

2021 ◽  
pp. 105381
Author(s):  
Georg S. Kranz ◽  
Marie Spies ◽  
Chrysoula Vraka ◽  
Ulrike Kaufmann ◽  
Eva-Maria Klebermass ◽  
...  
Keyword(s):  
Monoamine Oxidase ◽  
Human Brain ◽  
Preliminary Report ◽  
Monoamine Oxidase A ◽  
High Dose ◽  
Testosterone Treatment
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