Pharmacotherapy of psychotic disorders in children and adolescents

2006 ◽  
pp. 195-254
Keyword(s):  
Children And Adolescents ◽  
Psychotic Disorders

scholarly journals Methylphenidate and the risk of psychotic disorders and hallucinations in children and adolescents in a large health system

2016 ◽  
Vol 6 (11) ◽  
pp. e956-e956 ◽  
Author(s):  
K K C Man ◽  
D Coghill ◽  
E W Chan ◽  
W C Y Lau ◽  
C Hollis ◽  
...  
Keyword(s):  
Health System ◽  
Children And Adolescents ◽  
Psychotic Disorders

494. A longitudinal MRI study of children and adolescents with atypical psychotic disorders

2000 ◽  
Vol 47 (8) ◽  
pp. S150
Author(s):  
R. Nicolson ◽  
J.N. Giedd ◽  
J. Blumenthal ◽  
S.D. Hamburger ◽  
M. Lenane ◽  
...  
Keyword(s):  
Children And Adolescents ◽  
Psychotic Disorders ◽  
Longitudinal Mri ◽  
Mri Study

Suicidal behaviors in children and adolescents with psychotic disorders

2017 ◽  
Vol 179 ◽  
pp. 13-16 ◽  
Author(s):  
Sarah Hope Lincoln ◽  
Emily Norkett ◽  
Kelsey Graber ◽  
Sahil Tembulkar ◽  
Nicholas Morelli ◽  
...  
Keyword(s):  
Children And Adolescents ◽  
Psychotic Disorders ◽  
Suicidal Behaviors

scholarly journals Neuroleptic prescribing in an adolescent psychiatric in-patient unit

1996 ◽  
Vol 20 (9) ◽  
pp. 538-540 ◽  
Author(s):  
K. Lowe ◽  
H. Smith ◽  
A. Clark
Keyword(s):  
Clinical Practice ◽  
Children And Adolescents ◽  
Antipsychotic Medication ◽  
Royal College ◽  
Psychotic Disorders ◽  
Consensus Statement ◽  
Comprehensive Evaluation ◽  
High Dose ◽  
Age Group ◽  
Antipsychotic Prescribing

The Royal College of Psychiatrists' consensus statement suggests that prescribing high dose antipsychotic medication in children and adolescents should rarely be necessary. Our objective was to study the prescribing of antipsychotic medication in a regional adolescent unit during a three-year period. We found that antipsychotic prescribing on this unit is common in psychotic disorders and often high closes are required. This is not in keeping with the recommendations of the consensus statement. Review of clinical practice on other adolescent units is needed, together with a more comprehensive evaluation of the outcome of psychotic disorders in this age group.

Abnormal neuroradiological findings in children and adolescents with affective and non-affective psychotic disorders

2019 ◽  
Vol 29 ◽  
pp. S598-S599
Author(s):  
J. Pinzon Espinosa ◽  
A. Fortea ◽  
L. Espinosa ◽  
L. Lazaro ◽  
R. Calvo ◽  
...  
Keyword(s):  
Children And Adolescents ◽  
Psychotic Disorders

Relationship Between Daily Dose, Serum Concentration, and Clinical Response to Quetiapine in Children and Adolescents with Psychotic and Mood Disorders

2017 ◽  
Vol 50 (06) ◽  
pp. 248-255 ◽  
Author(s):  
Laura Albantakis ◽  
Karin Egberts ◽  
Rainer Burger ◽  
Christine Kulpok ◽  
Claudia Mehler-Wex ◽  
...  
Keyword(s):  
Serum Concentration ◽  
Children And Adolescents ◽  
Mood Disorders ◽  
Lower Limit ◽  
Psychotic Disorders ◽  
Rating Scale ◽  
Short Form ◽  
Adult Patients ◽  
Therapeutic Drug ◽  
Daily Dose

Abstract Introduction In child and adolescent psychiatry, therapeutic drug monitoring (TDM) is strongly recommended. However, therapeutic ranges (TR) are defined only for adults. The objectives of this naturalistic study were to assess the relationships between serum quetiapine concentration, daily dose, and clinical outcomes as well as the determinants of pharmacokinetic variability. Furthermore, it was elucidated whether the recommended TR for adult patients with psychotic disorders is valid for children and adolescents. Methods TDM was performed in 180 pediatric patients treated with quetiapine. Psychopathological changes were assessed by the Clinical Global Impression – Improvement scale (CGI-I). Adverse drug reactions (ADRs) were assessed by using a short form of the Udvalg for Kliniske Undersogelser (UKU) side effect rating scale. Results A weak positive linear relationship between daily dose (mean 349.9±248.9 mg/day) and serum concentration of quetiapine (rs=0.496, p<0.001) was found (mean age 15.6±1.9 years, 45.6% male, 31.1% monotherapy), but no relationship between serum concentration and clinical outcome was found. Dose variation accounted for only 12.5% (rs 2=0.125) of the variability of serum concentrations. No effects by gender, age, body weight, smoking habits, and co-medication were found. The majority of patients with psychotic (67.8%) and mood disorders (74.5%) showed a serum concentration below the suggested lower limit (100 ng/mL) of the TR for adults. Discussion There are several limitations of this study because of the naturalistic design, and our results should therefore be interpreted with caution. Notwithstanding, our data suggest that the lower limit of the TR for quetiapine is lower than the limit in adult patients.

scholarly journals Specificities of psychoses in children and adolescents with mental retardation

2003 ◽  
Vol 56 (5-6) ◽  
pp. 251-255
Author(s):  
Dusan Kolar ◽  
Svetomir Bojanin ◽  
Mila Kolar
Keyword(s):  
Mental Retardation ◽  
Children And Adolescents ◽  
Social Factors ◽  
Psychotic Disorders ◽  
Neurodevelopmental Disorder ◽  
Mentally Retarded ◽  
Differential Diagnostics ◽  
Mentally Retarded Children ◽  
Clinical Pictures ◽  
Developmental Psychiatry

Mental retardation is a heterogeneous neurodevelopmental disorder characterized by arrested or incomplete psychological development. The first part of the study deals with psychological and biological factors: etiology and pathogenesis of mental retardation and comorbid psychiatric disorders Their etiopathogenesis is similar as in other neurodevelopmental disorders and it was analyzed in the part dealing with biological specificities of persons with mental retardation. Numerous bio-psycho-social factors cause increased vulnerability of the mentally retarded to development of mental disorders. Thus, prevalence of these disorders is higher in mentally retarded persons than in general population. This study also deals with specificities regarding diagnosis of psychotic disorders in mentally retarded persons as well as neurobiologic, epidemiologic, clinical and therapeutic characteristics of schizophrenic psychoses, autism and affective disorders in persons with mental retardation. Special emphasis was given to diagnostics of these disorders in mentally retarded children and adolescents, as well as to problems of differential diagnostics. Apart from other things, we have concluded that specific clinical pictures demand subspeciality approach in the frame of developmental psychiatry.

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