Novel Approaches to Immunotherapy for Food Allergy

2004 ◽  
pp. 688-705
Keyword(s):  
Food Allergy ◽  
Novel Approaches

scholarly journals Novel Approaches to Food Allergy Management During COVID-19 Inspire Long-Term Change

2020 ◽  
Vol 8 (9) ◽  
pp. 2851-2857 ◽  
Author(s):  
Douglas P. Mack ◽  
Edmond S. Chan ◽  
Marcus Shaker ◽  
Elissa M. Abrams ◽  
Julie Wang ◽  
...  
Keyword(s):  
Food Allergy ◽  
Term Change ◽  
Novel Approaches ◽  
Allergy Management

scholarly journals Novel Approaches in the Inhibition of IgE-Induced Mast Cell Reactivity in Food Allergy

2021 ◽  
Vol 12 ◽  
Author(s):  
Chiara Tontini ◽  
Silvia Bulfone-Paus
Keyword(s):  
Mast Cell ◽  
Monoclonal Antibodies ◽  
Food Allergy ◽  
Mast Cells ◽  
Specific Ige ◽  
Mast Cell Activation ◽  
Type I ◽  
Allergen Specific Immunotherapy ◽  
Immunological Mechanisms ◽  
Novel Approaches

Allergy is an IgE-dependent type-I hypersensitivity reaction that can lead to life-threatening systemic symptoms such as anaphylaxis. In the pathogenesis of the allergic response, the common upstream event is the binding of allergens to specific IgE, inducing cross-linking of the high-affinity FcεRI on mast cells, triggering cellular degranulation and the release of histamine, proteases, lipids mediators, cytokines and chemokines with inflammatory activity. A number of novel therapeutic options to curb mast cell activation are in the pipeline for the treatment of severe allergies. In addition to anti-IgE therapy and allergen-specific immunotherapy, monoclonal antibodies targeted against several key Th2/alarmin cytokines (i.e. IL-4Rα, IL-33, TSLP), active modification of allergen-specific IgE (i.e. inhibitory compounds, monoclonal antibodies, de-sialylation), engagement of inhibitory receptors on mast cells and allergen-specific adjuvant vaccines, are new promising options to inhibit the uncontrolled release of mast cell mediators upon allergen exposure. In this review, we critically discuss the novel approaches targeting mast cells limiting allergic responses and the immunological mechanisms involved, with special interest on food allergy treatment.

Novel Approaches to Food Allergy

2013 ◽  
Vol 46 (3) ◽  
pp. 250-257 ◽  
Author(s):  
Yao-Hsu Yang ◽  
Bor-Luen Chiang
Keyword(s):  
Food Allergy ◽  
Novel Approaches

Novel Approaches to Low-Voltage Scanning Electron Microscopy

1990 ◽  
Vol 48 (1) ◽  
pp. 366-367
Author(s):  
Arthur V. Jones
Keyword(s):  
Electron Microscopy ◽  
Scanning Electron Microscopy ◽  
Low Voltage ◽  
Electron Optics ◽  
Current Interest ◽  
New Concepts ◽  
Opportune Time ◽  
Novel Approaches ◽  
Voltage Scanning ◽  
Scanning Electron

In comparison with the developers of other forms of instrumentation, scanning electron microscope manufacturers are among the most conservative of people. New concepts usually must wait many years before being exploited commercially. The field emission gun, developed by Albert Crewe and his coworkers in 1968 is only now becoming widely available in commercial instruments, while the innovative lens designs of Mulvey are still waiting to be commercially exploited. The associated electronics is still in general based on operating procedures which have changed little since the original microscopes of Oatley and his co-workers.The current interest in low-voltage scanning electron microscopy will, if sub-nanometer resolution is to be obtained in a useable instrument, lead to fundamental changes in the design of the electron optics. Perhaps this is an opportune time to consider other fundamental changes in scanning electron microscopy instrumentation.

Skin Prick Wheals Over 8 mm Signal Food Allergy

2011 ◽  
Vol 42 (5) ◽  
pp. 34
Author(s):  
SHERRY BOSCHERT
Keyword(s):  
Food Allergy

‘Persistent GERD’ May Actually Be Food Allergy

2005 ◽  
Vol 38 (21) ◽  
pp. 78
Author(s):  
SHERRY BOSCHERT
Keyword(s):  
Food Allergy
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