Processable Aqueous Dispersion of Fullerene C60: A Nanofl uid

Objective: The intension of the present study includes fabrication and optimization of mouth dissolving film loaded with Chlorothalidone by solvent evaporation techniques using two components and their three levels as multilevel Categoric design. Methods: Major problem associated with the development of film loaded with BCS class II drug is to increase its solubility. Here the Chlorothalidone solubility achieved by co-solvents, such as methanol. After dissolving the drug in co-solvent, this drug solution is poured into an aqueous dispersion of Hydroxypropyl Methylcellulose E5 (HPMC E5) and Polyethylene glycol 400 (PEG 400). The two independent variables selected are factor A (concentration of HPMC E5) and factor B (concentration of PEG 400) was selected on the basis of preliminary trials. The percentage drug release (R1), Disintegration time in sec (R2) and folding endurance (R3) were selected as dependent variables. Here HPMC E5 used as a film former, PEG 400 as plasticizer, mannitol as bulking agent, Sodium starch glycolate as a disintegrating agent, tween 80 as the surfactant, tartaric acid as saliva stimulating agent, sodium saccharin as a sweetener and orange flavour etc. These fabricated films were evaluated for physicochemical properties, disintegration time and In vitro drug release study. Results: The formulation F6 has more favorable responses as per multilevel categoric design is % drug release about 98.95 %, average disintegration time about 24.33 second and folding endurance is 117. Thus formulation F6 was preferred as an optimized formulation. Conclusion: The present formulation delivers medicament accurately with good therapeutic efficiency by oral administration, this mouth dissolving films having a rapid onset of action than conventional tablet formulations.

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Effect of fullerene C60 on morphofunctional state of seminiferous tubules of the testes after vitrification

Cryobiology ◽

10.1016/j.cryobiol.2020.10.211 ◽

2020 ◽

Vol 97 ◽

pp. 304

Author(s):

Nataliia Volkova ◽

Mariia Yukhta ◽

Larisa Sokil ◽

Lyudmyla Chernyshenko ◽

Lyudmyla Stepanyuk ◽

...

Keyword(s):

Fullerene C60 ◽

Seminiferous Tubules

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Fullerene C60 promoted photochemical hydroamination reactions of an electron deficient alkyne with trimethylsilyl group containing tertiary N-alkylbenzylamines

RSC Advances ◽

10.1039/d1ra00166c ◽

2021 ◽

Vol 11 (11) ◽

pp. 5914-5922

Author(s):

Suk Hyun Lim ◽

Hannara Jang ◽

Dae Won Cho

Keyword(s):

Fullerene C60 ◽

Dimethyl Acetylenedicarboxylate ◽

Trimethylsilyl Group

C60-promoted photoaddition reactions of N-α-trimethylsilyl-N-alkylbenzylamines with dimethyl acetylenedicarboxylate (DMAD) were carried out.

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Strain Sensor Based on Biological Nanomaterial

Engineering Proceedings ◽

10.3390/i3s2021dresden-10115 ◽

2021 ◽

Vol 6 (1) ◽

pp. 23

Author(s):

Levan P. Ichkitidze ◽

Alexander Yu. Gerasimenko ◽

Dmitry V. Telyshev ◽

Eugeny P. Kitsyuk ◽

Vladimir A. Petukhov ◽

...

Keyword(s):

Screen Printing ◽

Respiratory Diseases ◽

Specific Conductivity ◽

Strain Sensor ◽

Aqueous Dispersion ◽

Strain Sensors ◽

Bending Angle ◽

Multi Walled Carbon Nanotubes ◽

Number Of Cycles ◽

Walled Carbon Nanotubes

We investigated a prototype of a strain sensor based on the layers of a bionanomaterial containing bovine serum albumin (BSA matrix) and multi-walled carbon nanotubes (MWCNT filler). The aqueous dispersion of 25 wt.% BSA/0.3 wt.% MWCNT was applied by screen printing onto flexible polyethylene terephthalate substrates. After drying the layers by laser irradiation (~970 nm), various parameters of the layers were controlled, i.e., resistance R, bending angle θ, number of cycles n, and measurement time. One measurement cycle corresponded to a change within the range θ = ±150°. The layers of the BSA/MWCNT bionanomaterial had dimensions of (15 ÷ 20) mm × (8 ÷ 10) mm × (0.5 ÷ 1. 5) µm. The dependences of resistance R on the bending angle θ were similar for all layers at θ = ±30, and the R(θ) curves represented approximate linear dependences (with an error of ≤ 10%); beyond this range, the dependences became nonlinear. The following quantitative values were obtained for the investigated strain sensor: specific conductivity ~1 ÷ 10 S/m, linear strain sensitivity ~160, and bending sensitivity 1.0 ÷ 1.5%/°. These results are high. The examined layers of the bionanomaterial BSA/MWCNT as a strain sensor are of particular interest for medical practice. In particular, strain sensors can be implemented by applying a water dispersion of nanomaterials to human skin using a 3D printer for monitoring movements (arms and blinking) and the detection of signs of pathology (dysphagia, respiratory diseases, angina, etc.).

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A novel tricationic fullerene C60 as broad-spectrum antimicrobial photosensitizer: mechanisms of action and potentiation with potassium iodide

Photochemical & Photobiological Sciences ◽

10.1007/s43630-021-00021-1 ◽

2021 ◽

Vol 20 (3) ◽

pp. 327-341

Author(s):

Maximiliano L. Agazzi ◽

Javier E. Durantini ◽

Ezequiel D. Quiroga ◽

M. Gabriela Alvarez ◽

Edgardo N. Durantini

Keyword(s):

Potassium Iodide ◽

Broad Spectrum ◽

Mechanisms Of Action ◽

Fullerene C60

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Influence of surfactants in improving degradation of polluting dyes photocatalyzed by TiO2 in aqueous dispersion

Journal of Photochemistry and Photobiology A Chemistry ◽

10.1016/j.jphotochem.2021.113342 ◽

2021 ◽

pp. 113342

Author(s):

Raimondo Germani ◽

Marzia Bini ◽

Simona Fantacci ◽

Federica Simonetti ◽

Matteo Tiecco ◽

...

Keyword(s):

Aqueous Dispersion

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