Monitoring the Impact of Asthma Drug Therapy: Database Studies

2005 ◽  
pp. 531-558
Keyword(s):  
Drug Therapy ◽  
Asthma Drug ◽  
The Impact

S275 – Nasal Morphology and Nasal Patency in Leprosy Patients

2008 ◽  
Vol 139 (2_suppl) ◽  
pp. P167-P167
Author(s):  
Maria Teresa Torres Larrosa ◽  
Luis Jorge Peréz Peréz ◽  
Juan-Jose Artazkoz-del Toro
Keyword(s):  
Drug Therapy ◽  
Therapy Group ◽  
Control Group ◽  
Nasal Patency ◽  
Multidrug Therapy ◽  
Airway Patency ◽  
Expiratory Resistance ◽  
Leprosy Patients ◽  
The Right ◽  
The Impact

Objectives 1) To assess the impact of multi-drug leprosy therapy on the development of nasal deformities and nasal airway patency. 2) Evaluate the nasal morphology and nasal patency in leprosy patients treated with the multidrug therapy in comparison with patients treated with 1 drug therapy and a group of healthy volunteers. Methods In an overall group of 84 patients studied, 38 were treated with a therapy based on a single drug, and 22 were treated with multi-drug therapy, while 24 subjects formed a control group. We used anterior rhinoscopy to analised the morphology of the nose. We meassured the nasal inspiratory and expiratory resistance of the right and left nostrils and total nasal inspiratory and expiratory resistance at a transnasal pressure of 150 Pa. by using active anterior rhinomanometry. The statistical analysis was carried out using the Varianza analisys. Results The nasal structures in the 1-drug therapy group underwent bone and cartilaginous resorption with an increase in nasal resistances. We found significant statistical differences between the resistance values obtained in this group and the control group (p<0,05). In the multidrug therapy group, the morphology of the nose remains as in healthy patients. No significant statistical differences were found between the resistance values obtained in the multidrug therapy patients and the control group (P>0,05). Conclusions The multidrug therapy prevents developing nasal deformities and maintains a normal nasal airflow.

A THEORETICAL ASSESSMENT OF THE EFFECTS OF DISTRIBUTED DELAY ON THE TRANSMISSION DYNAMICS OF HEPATITIS B

2015 ◽  
Vol 23 (03) ◽  
pp. 423-455
Author(s):  
P. MOUOFO TCHINDA ◽  
JEAN JULES TEWA ◽  
BOULECHARD MEWOLI ◽  
SAMUEL BOWONG
Keyword(s):  
Drug Therapy ◽  
Hepatitis B ◽  
Basic Reproduction Number ◽  
Disease Transmission ◽  
Time Delays ◽  
Reproduction Number ◽  
Distributed Delay ◽  
Global Dynamics ◽  
The Impact ◽  
The Basic Reproduction Number

In this paper, we investigate the global dynamics of a system of delay differential equations which describes the interaction of hepatitis B virus (HBV) with both liver and blood cells. The model has two distributed time delays describing the time needed for infection of cell and virus replication. We also include the efficiency of drug therapy in inhibiting viral production and the efficiency of drug therapy in blocking new infection. We compute the basic reproduction number and find that increasing delays will decrease the value of the basic reproduction number. We study the sensitivity analysis on the key parameters that drive the disease dynamics in order to determine their relative importance to disease transmission and prevalence. Our analysis reveals that the model exhibits the phenomenon of backward bifurcation (where a stable disease-free equilibrium (DFE) co-exists with a stable endemic equilibrium when the basic reproduction number is less than unity). Numerical simulations are presented to evaluate the impact of time-delays on the prevalence of the disease.

Advances and Controversies in Adult ICU Sedation, Part 1: An Overview of the Importance of Sedation and Agitation and Subjective Assessment Tools for Patient Evaluation

2001 ◽  
Vol 36 (12) ◽  
pp. 1266-1278
Author(s):  
Gilles L. Fraser ◽  
Richard Riker
Keyword(s):  
Health Care ◽  
Drug Therapy ◽  
Critically Ill ◽  
Subjective Assessment ◽  
Assessment Tools ◽  
Critically Ill Patient ◽  
Patient Evaluation ◽  
Icu Patients ◽  
Icu Sedation ◽  
The Impact

This feature examines the impact of pharmacologic interventions on the treatment of the critically ill patient—an area of health care that has become increasingly complex. It will review recent advances (including evolving and controversial data) in drug therapy for adult ICU patients and assess these new modalities in terms of clinical, humanistic, and economic outcomes. Direct questions or comments to Gil Fraser, PharmD, at [email protected] .

Asthma drug therapy trends in the United States, 1972 to 1985

1987 ◽  
Vol 80 (3) ◽  
pp. 398-402 ◽  
Author(s):  
L.A. Bosco ◽  
D.E. Knapp ◽  
B. Gerstman ◽  
C.F. Graham
Keyword(s):  
United States ◽  
Drug Therapy ◽  
The United States ◽  
Asthma Drug

scholarly journals The impact of renal protection clinics on prescription of and adherence to cardioprotective drug therapy in chronic kidney disease patients

2017 ◽  
Vol 10 (3) ◽  
pp. 375-380
Author(s):  
Fanny Lepeytre ◽  
Héloise Cardinal ◽  
Lorraine Fradette ◽  
Jacobien Verhave ◽  
Marc Dorais ◽  
...  
Keyword(s):  
Chronic Kidney Disease ◽  
Drug Therapy ◽  
Kidney Disease ◽  
Renal Protection ◽  
The Impact ◽  
Cardioprotective Drug

Treatment of chronic pain by using intrathecal drug therapy compared with conventional pain therapies: a cost-effectiveness analysis

2002 ◽  
Vol 97 (4) ◽  
pp. 803-810 ◽  
Author(s):  
Krishna Kumar ◽  
Gary Hunter ◽  
Denny D. Demeria
Keyword(s):  
Cost Effectiveness ◽  
Drug Therapy ◽  
Breakthrough Pain ◽  
Control Group ◽  
Consecutive Series ◽  
Content Type ◽  
Failed Back Syndrome ◽  
Hospitalization Costs ◽  
The Impact ◽  
Fine Print

Object. The object of this study was to compare the cost-effectiveness of intrathecal drug therapy (IDT) with that of conventional pain therapy (CPT) in patients suffering from chronic low back pain caused by failed back syndrome. In this study, the authors tabulated actual costs, in Canadian dollars, in a consecutive series of patients undergoing IDT within the Canadian health care system and have compared them with costs in a control group in the same environment. The influence of these treatments on the quality of life (QOL) was also analyzed. Methods. The authors report on a series of 67 patients suffering from failed back syndrome, 23 of whom underwent implantation of a programmable drug delivery pump and 44 of whom acted as controls. Patients were followed for a 5-year period during which the investigators tabulated the actual costs incurred for diagnostic imaging, professional fees, implantation costs including hardware, nursing visits for maintenance of the pumps, alternative therapies, and hospitalization costs for breakthrough pain. From this data, cumulative costs for each group were calculated for a 5-year period. Patient responses on the Oswestry Pain Questionnaire were analyzed to assess the impact of treatment on QOL. The actual cumulative costs for IDT during a 5-year period were $29,410, as opposed to $38,000 for CPT. High initial costs of equipment required for IDT were recovered by 28 months. After this time point, managing patients with CPT became the more expensive treatment option for the remainder of the follow-up period. The Oswestry Disability Index showed a 27% improvement for patients in the IDT group, compared with a 12% improvement in the control group. Conclusions. In patients who respond to this treatment, IDT is cost effective in the long term despite high initial costs of implantable devices.

Corticosteroids in ARDS: The Never-Ending Story

2007 ◽  
Vol 42 (8) ◽  
pp. 691-701 ◽  
Author(s):  
Zachariah Thomas ◽  
Katarzyna Kimborowicz
Keyword(s):  
Health Care ◽  
Intensive Care Unit ◽  
Intensive Care ◽  
Drug Therapy ◽  
Critically Ill ◽  
Economic Outcomes ◽  
Critically Ill Patient ◽  
Adult Intensive Care Unit ◽  
Recent Advances ◽  
The Impact

This feature examines the impact of pharmacologic interventions on the treatment of the critically ill patient — an area of health care that has become increasingly complex. Recent advances in drug therapy (including evolving and controversial data) for adult intensive-care-unit patients will be reviewed and assessed in terms of clinical, humanistic, and economic outcomes.

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