Classification and Evaluation of the Overweight Patient

2003 ◽  
pp. 16-47 ◽  
Keyword(s):  
2010 ◽  
Vol 8 (5) ◽  
pp. 318-321 ◽  
Author(s):  
Elodie Descloux ◽  
Frédérique De Monbrison ◽  
Cécile Basselin ◽  
Thierry Vial ◽  
François Peyron

Endocrine ◽  
2000 ◽  
Vol 13 (2) ◽  
pp. 167-186 ◽  
Author(s):  
George A. Bray ◽  
Donna H. Ryan

Angiology ◽  
2003 ◽  
Vol 54 (2) ◽  
pp. 181-186 ◽  
Author(s):  
Saim Yologlu ◽  
Alpay Turan Sezgin ◽  
Ramazan Ozdemir ◽  
Nurzen Sezgin ◽  
Cemil Colak ◽  
...  

2003 ◽  
Vol 20 (s4) ◽  
pp. 10-13
Author(s):  
P. Peter ◽  
S. Kumar

2013 ◽  
Vol 47 (1) ◽  
pp. e4-e4
Author(s):  
Célia Lloret-Linares ◽  
Stéphane Mouly ◽  
Dan-Tranh Hoang-Nguyen ◽  
John Evans ◽  
Laurent Raskine ◽  
...  

OBJECTIVE To report a case of an overweight man with lymph node tuberculosis due to Mycobacterium bovis, a part of the Mycobacterium tuberculosis complex, treated with fixed-dose combination (FDC) chemotherapy. CASE REPORT Following guidelines, according to the patient's weight (92 kg), we prescribed the maximum recommended doses of isoniazid-rifampin-pyrazinamide FDC. It led initially to underdosing, with a poor clinical outcome, justifying increased doses and a complex regimen using separate drugs (isoniazid 600 mg, rifampin 1200 mg, and levofloxacin 1000 mg) to achieve therapeutic drug concentrations and clinical response. DISCUSSION Usually recommended doses of FDC chemotherapies may be inappropriate in overweight patients. We discuss here the different factors that may be involved in poor clinical outcomes, particularly the consequences of excess weight on drug metabolism: drug-drug interaction, FDC use, generic formulation use, intestinal malabsorption, and acetylation profile. CONCLUSIONS Therapeutic drug monitoring in overweight patients may be useful in the clinical setting to help clinicians individualize drug therapeutic regimens and optimize drug response, adherence, and safety.


2007 ◽  
Vol 59 (2) ◽  
pp. 151-184 ◽  
Author(s):  
George A. Bray ◽  
Frank L. Greenway

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