Solubility of Pharmaceutical Solids

1995 ◽  
pp. 321-386 ◽  
Author(s):  
David Grant
Keyword(s):  
Pharmaceutical Solids

Surface characterization of pharmaceutical solids

2021 ◽  
Vol 138 ◽  
pp. 116228
Author(s):  
Amanpreet Kaur ◽  
Dnyaneshwar P. Kale ◽  
Arvind K. Bansal
Keyword(s):  
Surface Characterization ◽  
Pharmaceutical Solids

Wettability of pharmaceutical solids: its measurement and influence on wet granulation

2002 ◽  
Vol 206 (1-3) ◽  
pp. 547-554 ◽  
Author(s):  
D Zhang ◽  
J.H Flory ◽  
S Panmai ◽  
U Batra ◽  
M.J Kaufman
Keyword(s):  
Wet Granulation ◽  
Pharmaceutical Solids

Hygroscopicity and Hydrates in Pharmaceutical Solids

2018 ◽  
pp. 159-188
Author(s):  
Susan M. Reutzel-Edens ◽  
Doris E. Braun ◽  
Ann W. Newman
Keyword(s):  
Pharmaceutical Solids

scholarly journals Stability of Amorphous Pharmaceutical Solids: Crystal Growth Mechanisms and Effect of Polymer Additives

2012 ◽  
Vol 14 (3) ◽  
pp. 380-388 ◽  
Author(s):  
Ye Sun ◽  
Lei Zhu ◽  
Tian Wu ◽  
Ting Cai ◽  
Erica M. Gunn ◽  
...  
Keyword(s):  
Crystal Growth ◽  
Polymer Additives ◽  
Growth Mechanisms ◽  
Pharmaceutical Solids

Bubble-induced fast crystal growth of indomethacin polymorphs in a supercooled liquid

2021 ◽  
Vol 54 (5) ◽  
Author(s):  
Qin Shi ◽  
Fang Li ◽  
Jia Xu ◽  
Lingling Wu ◽  
Junbo Xin ◽  
...  
Keyword(s):  
Crystal Growth ◽  
Physical Stability ◽  
Pharmaceutical Formulations ◽  
Supercooled Liquid ◽  
Pharmaceutical Solids ◽  
Liquid Bubble ◽  
Different Temperatures ◽  
Surface Crystal

Physical stability is one of the main challenges when developing robust amorphous pharmaceutical formulations. This article reports fast crystal growth behaviors of the γ and α forms of indomethacin (IMC) initiated by bubbles in the interior of a supercooled liquid. Bubble-induced crystal growth of γ-IMC exhibits approximately the same kinetics as its surface crystal growth, supporting the view that bubble-induced crystal growth is a surface-facilitated process. In contrast, the rates of bubble-induced crystal growth of α-IMC are much faster than those of its surface crystal growth. These results indicate that the bubble-induced crystal growth not only depends on the interface created by the bubble but also strongly correlates with the true cavitation of the bubble. Moreover, bubble-induced fast crystal growth of γ- and α-IMC can be terminated at different temperatures by cooling. These outcomes are meaningful for the in-depth understanding of physical stability and pre-formulation study of amorphous pharmaceutical solids showing surface-facilitated crystal growth.

scholarly journals PVP-H2O2 Complex as a New Stressor for the Accelerated Oxidation Study of Pharmaceutical Solids

Pharmaceutics ◽  
2019 ◽  
Vol 11 (9) ◽  
pp. 457 ◽  
Author(s):  
Dattatray Modhave ◽  
Brenda Barrios ◽  
Amrit Paudel
Keyword(s):  
Hydrogen Peroxide ◽  
Solid State ◽  
Pharmaceutical Products ◽  
Screening Methods ◽  
Forced Degradation ◽  
Pharmaceutical Solids ◽  
Drug Degradation ◽  
Oxidation Study ◽  
Degradation Reactions ◽  
Forced Oxidation

Reactive impurities, such as hydrogen peroxide in excipients, raise a great concern over the chemical stability of pharmaceutical products. Traditional screening methods of spiking impurities into solid drug-excipient mixtures oversimplify the micro-environment and the physical state of such impurities in real dosage form. This can lead to an inaccurate prediction of the long-term product stability. This study presents the feasibility of using a polyvinylpyrrolidone-hydrogen peroxide complex (PVP-H2O2) as an oxidative agent for the solid state forced degradation of a selected drug, vortioxetine HBr. The PVP-H2O2 complex was prepared and characterized using FT-IR spectroscopy. The tablet compacts were made using a mixture of solid PVP-H2O2 complex and crystalline vortioxetine HBr powder. The compacts were exposed to 40 °C/75% RH condition in open and closed states for different time intervals. The extent and the type of drug degradation were analysed using LC and LC-MS. The extent of degradation was higher in the samples stored at the open state as compared to the close state. The solution state forced oxidation was conducted to verify the peroxide induced degradation reactions. The results evidence the utility of the proposed solid-state stressor and the method for screening the sensitivity of drugs to the excipient reactive impurities involving peroxides in solid-state.

Three-Dimensional NMR Spectroscopy of Fluorinated Pharmaceutical Solids under Ultrafast Magic Angle Spinning

2019 ◽  
Vol 91 (9) ◽  
pp. 6217-6224 ◽  
Author(s):  
Xingyu Lu ◽  
Daniel Skomski ◽  
Karen C. Thompson ◽  
Michael J. McNevin ◽  
Wei Xu ◽  
...  
Keyword(s):  
Nmr Spectroscopy ◽  
Three Dimensional ◽  
Magic Angle Spinning ◽  
Magic Angle ◽  
Pharmaceutical Solids ◽  
Angle Spinning
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