Antitumor Immune Memory and its Activation for Control of Residual Tumor Cells and Improvement of Patient Survival: A New Concept Derived from Translational Research with the Virus-Modified Tumor Vaccine ATV-NDV

2004 ◽  
pp. 497-548
Keyword(s):  
Translational Research ◽  
Tumor Cells ◽  
Patient Survival ◽  
Tumor Vaccine ◽  
Residual Tumor ◽  
Immune Memory

What are the risk factors for residual tumor cells after endoscopic complete resection in gastric epithelial neoplasia?

2014 ◽  
Vol 29 (2) ◽  
pp. 487-492 ◽  
Author(s):  
Gak Won Yun ◽  
Jie-Hyun Kim ◽  
Yong Chan Lee ◽  
Sang Kil Lee ◽  
Sung Kwan Shin ◽  
...  
Keyword(s):  
Risk Factors ◽  
Tumor Cells ◽  
Residual Tumor ◽  
Complete Resection ◽  
Gastric Epithelial Neoplasia

Identification of the signature genes and network of Reactive Oxygen Species (ROS) related genes and DNA repair genes in Lung Adenocarcinoma (LUAD)

2021 ◽  
Author(s):  
Ye Zhao ◽  
Hai-Ming Feng ◽  
Xiao-Ping Wei ◽  
Wei-Jian Yan ◽  
Bin Li ◽  
...  
Keyword(s):  
Reactive Oxygen Species ◽  
Dna Repair ◽  
Tumor Cell ◽  
Lung Adenocarcinoma ◽  
Tumor Cells ◽  
Patient Survival ◽  
Reactive Oxygen ◽  
Dna Repair Genes ◽  
Oxygen Species ◽  
Repair Genes

Abstract Reactive Oxygen Species (ROS) are present in high amount in patients with tumors, and these ROS can kill and destroy tumor cells. Thus, tumor cells upregulate ROS-related genes to protect themselves and reduce their destruction. Cancer cells already damaged by ROS can be repaired by expressing DNA repair genes consequently promoting their proliferation. In this work, lung adenocarcinoma (LUAD) transcriptome data in the TCGA database was analyzed and samples were clustered into 5 ROS-related categories and 6 DNA repair categories. Survival analysis revealed a significant difference in patient survival between the two classification methods. In addition, the samples corresponding to the two categories overlap, thus, the gene expression profile of the same sample with different categories and survival prognosis was further explored, and the connection between ROS-related genes and DNA repair genes was investigated. The interactive sample recombination classification was used, revealing that the patient's prognosis was worse when the ROS-related genes and DNA repair genes were expressed at the same time. The further research on the potential regulatory network of the two categories of genes and the correlation analysis revealed that ROS-related genes and DNA repair genes have a mutual regulatory relationship. The ROS-related genes NQO1, TXNRD1, and PRDX4 could establish links with other DNA repair genes through the DNA repair gene NEIL3, thereby increasing the growth of tumor cells and balancing the level of ROS, leading to tumor cell death and constant damage to the tumor cell repair system, thus prolonging patient survival. Thus, targeting ROS-related genes and DNA repair genes might be a promising strategy in the treatment of LUAD. Finally, a survival prognostic model of ROS-related genes and DNA repair genes was established (TERT, PRKDC, PTTG1, SMUG1, TXNRD1, CAT, H2AFX and PFKP), the risk score might be used as an independent prognostic factor in LUAD patients.

A New Recombinant Fibronectin/Cadherin Protein-Hydrophobically Modified Glycol Chitosan/Paclitaxel Layer-By-Layer Self-Assembly Strategy for the Postoperative Therapy of Osteosarcoma and Correlated Bone Injury

2021 ◽  
Vol 17 (9) ◽  
pp. 1765-1777
Author(s):  
Zaiyang Liu ◽  
Yiqun Wu ◽  
Hongjuan Dai ◽  
Shasha Li ◽  
Ying Zhu ◽  
...  
Keyword(s):  
Fusion Protein ◽  
Tumor Cells ◽  
Self Assembly ◽  
Blood Circulation ◽  
Residual Tumor ◽  
Layer By Layer ◽  
Glycol Chitosan ◽  
Hydrophobically Modified ◽  
Bone Injury

Osteosarcoma is one of the most aggressive cancers which greatly threatens the health of adolescents and surgery is difficult to resect the whole piece of tumor tissue. The residual tumor cells might proliferate at the tumor site and invade into the blood circulation, leading to tumor recurrence and metastasis. Besides, the invasion of tumor cells could also lead to bone injury. We designed a recombinant fibronectin-cadherin fusion protein/hydrophobically modified glycol chitosan-PTX nanoparticles (rFN-CDH/HGC-PTX) layer-by-layer self-assembly polymer based on biphasic calcium phosphate ceramic (BCP) (BCP-PEI-(rFN/CDH-PTX/HGC)n-rFN/CDH). The SEM, FTIR, XPS and contact angle experiments proved the successful synthesis of the polymer. The chemotherapy drug PTX and bone-repairing-related rFN/CDH fusion protein could be stably released within one week and the in vitro experiments exhibited the efficacy of the polymer to kill residual tumor cells and promote the proliferation of osteoblast, confirming that our polymer was a superior material for postoperative osteosarcoma therapy.

Methods to Study Primary Tumor Cells and Residual Tumor Cells in Mouse Models of Oncogene Dependence

2015 ◽  
pp. 381-394
Author(s):  
Caroline Botta ◽  
Cedric Darini ◽  
Guillaume Darrasse-Jèze ◽  
Katrina Podsypanina
Keyword(s):  
Tumor Cells ◽  
Mouse Models ◽  
Primary Tumor ◽  
Residual Tumor

scholarly journals Tumor vaccine composed of C-class CpG oligodeoxynucleotides and irradiated tumor cells induces long-term antitumor immunity

2010 ◽  
Vol 11 (1) ◽  
pp. 45 ◽  
Author(s):  
Petra Cerkovnik ◽  
Barbara Novakovic ◽  
Vida Stegel ◽  
Srdjan Novakovic
Keyword(s):  
Tumor Cells ◽  
Antitumor Immunity ◽  
Tumor Vaccine ◽  
Cpg Oligodeoxynucleotides
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