Role of Allergen-Specific Immunotherapy in Childhood Asthma

2005 ◽  
pp. 481-524
Keyword(s):  
Childhood Asthma ◽  
Specific Immunotherapy ◽  
Allergen Specific Immunotherapy

Effect of Vitamin D Adjuvant and Allergen Specific Immunotherapy on Serum IL-10 and IL-17 Levels in Childhood Asthma: A Controlled Clinical Trial

2021 ◽  
Vol 30 (1) ◽  
pp. 175-181
Author(s):  
Lobna A. El-Korashi ◽  
Ola E. Nafea ◽  
Lamiaa G. Zake ◽  
Faika Arab ◽  
Reham H. Anis
Keyword(s):  
Childhood Asthma ◽  
Specific Immunotherapy ◽  
Pediatric Asthma ◽  
Serum Levels ◽  
Atopic Asthma ◽  
Subcutaneous Immunotherapy ◽  
Controlled Clinical Trial ◽  
Inhaled Corticosteroid ◽  
Allergen Specific Immunotherapy ◽  
Few Data

Background: 1, 25-dihydroxy vitamin D3 (VitD3) can improve the effect of allergenspecific immunotherapy (SIT). Few data is available about its role in childhood asthma. Objective: To assess the immunological and clinical efficacy of VitD3 as an adjuvant to allergen specific immunotherapy in pediatric asthma. Methodology: Sixty nine children with atopic asthma were divided into three groups: a group received subcutaneous immunotherapy (SCIT) in combination with VitD3 (n=23), another group received SCIT alone (n=23), and the last group VitD3 alone (n=23). All children were assessed at baseline, and six months for rate of inhaled corticosteroid (ICS) discontinuation, and serum levels of IL-10, and IL-17A. Results: In the SCIT + vitD3, ICS discontinuation rate was higher compared to VitD3 alone group and SCIT alone group at the end of 6th month (P=0.555 and 0.016 respectively). The combined SCIT+ VitD3 group showed significant increase of serum IL-10 level in comparison to SCIT alone group and VitD3 alone group (P=0.000) and significant decrease in serum IL-17A level compared to VitD3 alone group (P= 0.011) Conclusion: VitD3 enhance the clinical and immunological outcomes of SIT in pediatric asthma. Further investigation is needed to evaluate this effect in a larger scale to confirm its role as an adjunct to SIT.

The Role of Anti-IgE Therapy in Combination with Allergen Specific Immunotherapy for Seasonal Allergic Rhinitis

BioDrugs ◽  
2007 ◽  
Vol 21 (6) ◽  
pp. 403-410 ◽  
Author(s):  
Philippe Stock ◽  
Claudia Rolinck-Werninghaus ◽  
Ulrich Wahn ◽  
Eckard Hamelmann
Keyword(s):  
Allergic Rhinitis ◽  
Seasonal Allergic Rhinitis ◽  
Specific Immunotherapy ◽  
Allergen Specific Immunotherapy

scholarly journals ASIT – A SOLUTION IN ALLERGY TREATMENT

2017 ◽  
pp. 116-119
Author(s):  
S. V. TSAREV
Keyword(s):  
Side Effects ◽  
Specific Immunotherapy ◽  
Sublingual Immunotherapy ◽  
Allergic Diseases ◽  
Action Mechanism ◽  
Allergen Specific Immunotherapy ◽  
Allergy Treatment ◽  
Paediatric Practice ◽  
Indications For Use

This article discusses the place and role of an allergen-specific immunotherapy in the treatment of allergic diseases. It provides an action mechanism, indications for use, contraindications, and side effects of an allergen-specific immunotherapy. A comparison of different methodologies for an allergen-specific immunotherapy was made. The advantages of sublingual allergen-specificimmunotherapy in paediatric practice were demonstrated. Provides data on the efficiency and safety of pollinosis sublingual immunotherapy with sensitization to grass

Immunomodulatory Role of Histamine H2 Receptor in Allergen-Specific Immunotherapy

2011 ◽  
Vol 144 (4) ◽  
pp. 500-505 ◽  
Author(s):  
Ji-Hyeon Shin ◽  
Byung-Guk Kim ◽  
Sung Won Kim ◽  
Jin-Hee Cho ◽  
Yong-Jin Park ◽  
...  
Keyword(s):  
Specific Immunotherapy ◽  
Allergen Specific Immunotherapy ◽  
Histamine H2 Receptor ◽  
H2 Receptor
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