Noninvasive Insulin-Delivery Systems: Options and Progress to Date

2002 ◽  
pp. 253-268
Keyword(s):  
Insulin Delivery ◽  
Delivery Systems

Strategies to improve insulin delivery through oral route: A review

2021 ◽  
Vol 18 ◽  
Author(s):  
Rohini Bhattacharya ◽  
Asha P. Johnson ◽  
Shailesh T. ◽  
Mohamed Rahamathulla ◽  
Gangadharappa H. V.
Keyword(s):  
Diabetes Mellitus ◽  
Drug Delivery ◽  
Drug Delivery Systems ◽  
Polymeric Micelles ◽  
Insulin Delivery ◽  
Peptide Hormone ◽  
Diabetes Mellitus Type 1 ◽  
Delivery Systems ◽  
Oral Insulin ◽  
Subcutaneous Route

: Diabetes mellitus is found to be among the most suffered and lethal diseases for mankind. Diabetes mellitus type-1 is caused by the demolition of pancreatic islets responsible for the secretion of insulin. Insulin is the peptide hormone (anabolic] that regulates the metabolism of carbohydrates, fats, and proteins. Upon the breakdown of the natural process of metabolism, the condition leads to hyperglycemia (increased blood glucose levels]. Hyperglycemia demands outsourcing of insulin. The subcutaneous route was found to be the most stable route of insulin administration but faces patient compliance problems. Oral Insulin delivery systems are the patient-centered and innovative novel drug delivery system, eliminating the pain caused by the subcutaneous route of administration. Insulin comes in contact across various barriers in the gastrointestinal tract, which has been discussed in detail in this review. The review describes about the different bioengineered formulations, including microcarriers, nanocarriers, Self-Microemulsifying drug delivery systems (SMEDDs), Self-Nanoemulsifying drug delivery systems (SNEDDs), polymeric micelles, cochleates, etc. Surface modification of the carriers is also possible by developing ligand anchored bioconjugates. A study on evaluation has shown that the carrier systems facilitate drug encapsulation without tampering the properties of insulin. Carrier-mediated transport by the use of natural, semi-synthetic, and synthetic polymers have shown efficient results in drug delivery by protecting insulin from harmful environment. This makes the formulation readily acceptable for a variety of populations. The present review focuses on the properties, barriers present in the GI tract, overcome the barriers, strategies to formulate oral insulin formulation by enhancing the stability and bioavailability of insulin.

scholarly journals The future of open- and closed-loop insulin delivery systems

2008 ◽  
Vol 60 (1) ◽  
pp. 1-13 ◽  
Author(s):  
Terry G. Farmer ◽  
Thomas F. Edgar ◽  
Nicholas A. Peppas
Keyword(s):  
Closed Loop ◽  
Insulin Delivery ◽  
Delivery Systems ◽  
The Future

Mucosal insulin delivery systems based on complexation polymer hydrogels: effect of particle size on insulin enteral absorption

2004 ◽  
Vol 97 (1) ◽  
pp. 115-124 ◽  
Author(s):  
Mariko Morishita ◽  
Takahiro Goto ◽  
Nicholas A Peppas ◽  
Jeffery I Joseph ◽  
Marc C Torjman ◽  
...  
Keyword(s):  
Particle Size ◽  
Insulin Delivery ◽  
Delivery Systems ◽  
Polymer Hydrogels ◽  
Enteral Absorption ◽  
Effect Of Particle Size

scholarly journals Automated Insulin Delivery Systems: Hopes and Expectations of Family Members

2018 ◽  
Vol 20 (3) ◽  
pp. 222-228 ◽  
Author(s):  
Kimberly P. Garza ◽  
Aneta Jedraszko ◽  
Lindsey E.G. Weil ◽  
Diana Naranjo ◽  
Katharine D. Barnard ◽  
...  
Keyword(s):  
Family Members ◽  
Insulin Delivery ◽  
Delivery Systems

Automated insulin delivery systems for people with type 1 diabetes

2021 ◽  
pp. 181-198
Author(s):  
Mert Sevil ◽  
Mudassir Rashid ◽  
Iman Hajizadeh ◽  
Mohammad Reza Askari ◽  
Nicole Hobbs ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
Insulin Delivery ◽  
Delivery Systems

scholarly journals Determining Physical Activity Characteristics From Wristband Data for Use in Automated Insulin Delivery Systems

2020 ◽  
Vol 20 (21) ◽  
pp. 12859-12870 ◽  
Author(s):  
Mert Sevil ◽  
Mudassir Rashid ◽  
Zacharie Maloney ◽  
Iman Hajizadeh ◽  
Sediqeh Samadi ◽  
...  
Keyword(s):  
Physical Activity ◽  
Insulin Delivery ◽  
Delivery Systems
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