Role of Lipids in Skin Barrier Function

Author(s):  
Mitsuhiro Denda
2018 ◽  
Vol 138 (5) ◽  
pp. S115
Author(s):  
M. Ota ◽  
T. Sasaki ◽  
T. Ebihara ◽  
S. Murata ◽  
S. Kaneko ◽  
...  

2012 ◽  
Vol 7 (3) ◽  
pp. 247-257 ◽  
Author(s):  
Regina Fölster-Holst ◽  
Stephan Dähnhardt-Pfeiffer ◽  
Dorothee Dähnhardt ◽  
Ehrhardt Proksch

2021 ◽  
Vol 12 ◽  
Author(s):  
Tom Macleod ◽  
Anna Berekmeri ◽  
Charlie Bridgewood ◽  
Martin Stacey ◽  
Dennis McGonagle ◽  
...  

The skin barrier would not function without IL-1 family members, but their physiological role in the immunological aspects of skin barrier function are often overlooked. This review summarises the role of IL-1 family cytokines (IL-1α, IL-1β, IL-1Ra, IL-18, IL-33, IL-36α, IL-36β, IL-36γ, IL-36Ra, IL-37 and IL-38) in the skin. We focus on novel aspects of their interaction with commensals and pathogens, the important impact of proteases on cytokine activity, on healing responses and inflammation limiting mechanisms. We discuss IL-1 family cytokines in the context of IL-4/IL-13 and IL-23/IL-17 axis-driven diseases and highlight consequences of human loss/gain of function mutations in activating or inhibitory pathway molecules. This review highlights recent findings that emphasize the importance of IL-1 family cytokines in both physiological and pathological cutaneous inflammation and emergent translational therapeutics that are helping further elucidate these cytokines.


2021 ◽  
Vol 7 (2) ◽  
pp. 1-6
Author(s):  
Franck Juchaux ◽  

Alterations of skin barrier function affect quality of life and there is a need to develop dermatological/cosmetic treatments to reinforce or restore it. Inspiring of Hailey-Hailey disease, in which barrier alteration is due to a mutation of a Calcium-transporting protein (ATP2C1), we focused on the role of minerals and more especially those contained in Saint-Gervais Mont Blanc (SGMB) spring water to reinforce barrier function. Objectives: Demonstrate the interest to enrich SGMB spring water with manganese to improve both keratinocytes differentiation and barrier function. Methods: Effects of treatments on the expression of ATP2C1 and on the expression of key markers in keratinocyte differentiation and barrier function were studied by gene expression analysis on keratinocytes monolayers and also by measuring the protein expression of transglutaminase 1 using in situ immunofluorescence and image analysis in keratinocytes monolayers. Results: SGMB spring water stimulates transcriptomic expression of key markers involved in keratinocytes differentiation and barrier function while manganese gluconate has no effect. Combination of both dramatically enhances keratinocytes differentiation, in a synergistic way, at both transcriptomic and protein level. None of treatments modulated ATP2C1 expression. Conclusion: These results highlight the interest to enrich SGMB spring water with manganese to boost keratinocytes differentiation and barrier function.


2019 ◽  
Vol 139 (5) ◽  
pp. S56
Author(s):  
H. Masaki ◽  
N. Kikuchi ◽  
T. Mizutani ◽  
Y. Okano

2021 ◽  
Vol 4 (1) ◽  
Author(s):  
Gihyeon Kim ◽  
Misun Kim ◽  
Minji Kim ◽  
Changho Park ◽  
Youngmin Yoon ◽  
...  

AbstractAn unbalanced microbial ecosystem on the human skin is closely related to skin diseases and has been associated with inflammation and immune responses. However, little is known about the role of the skin microbiome on skin aging. Here, we report that the Streptococcus species improved the skin structure and barrier function, thereby contributing to anti-aging. Metagenomic analyses showed the abundance of Streptococcus in younger individuals or those having more elastic skin. Particularly, we isolated Streptococcus pneumoniae, Streptococcus infantis, and Streptococcus thermophilus from face of young individuals. Treatment with secretions of S. pneumoniae and S. infantis induced the expression of genes associated with the formation of skin structure and the skin barrier function in human skin cells. The application of culture supernatant including Streptococcal secretions on human skin showed marked improvements on skin phenotypes such as elasticity, hydration, and desquamation. Gene Ontology analysis revealed overlaps in spermidine biosynthetic and glycogen biosynthetic processes. Streptococcus-secreted spermidine contributed to the recovery of skin structure and barrier function through the upregulation of collagen and lipid synthesis in aged cells. Overall, our data suggest the role of skin microbiome into anti-aging and clinical applications.


2016 ◽  
Vol 242 ◽  
pp. 105-118 ◽  
Author(s):  
Katja Bäsler ◽  
Sophia Bergmann ◽  
Michael Heisig ◽  
Arne Naegel ◽  
Michaela Zorn-Kruppa ◽  
...  

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