Pathophysiology of Gastroesophageal Reflux Disease: The Antireflux Barrier and Luminal Clearance Mechanisms

2000 ◽  
pp. 144-170
Keyword(s):  
Gastroesophageal Reflux Disease ◽  
Gastroesophageal Reflux ◽  
Reflux Disease ◽  
Antireflux Barrier

scholarly journals Endoscopic management of gastroesophageal reflux disease in 2012: What works and what doesn′t

2012 ◽  
Vol 03 (S 05) ◽  
pp. 013-016
Author(s):  
George Triadafilopoulos
Keyword(s):  
Gastroesophageal Reflux Disease ◽  
Gastroesophageal Reflux ◽  
Reflux Disease ◽  
Endoscopic Treatment ◽  
Endoscopic Therapy ◽  
Endoscopic Management ◽  
What Works ◽  
The Us ◽  
Multiple Devices ◽  
Antireflux Barrier

AbstractGastroesophageal reflux disease results primarily from the loss of an effective antireflux barrier, which forms a mechanical barrier against the retrograde movement of gastric contents. Multiple devices have been developed for the endoscopic treatment of GERD, using approaches such as sewing, transmural fasteners, endoscopic staplers, and thermal treatment. Devices that are currently commercially available for the endoscopic treatment of GERD in the US include: EndoCinch; EsophyX; Stretta. This article will highlight the endoscopic therapy of gastroesophageal reflux disease with focus on Stretta and EsophyX.

The role of nitric oxide in the development of gastroesophageal reflux disease against the backdrop of obesity

2021 ◽  
Vol 43 (3-4) ◽  
pp. 63-66
Author(s):  
O. M. Malіar ◽  
◽  
O .A. Oparin ◽  
Т. М. Oparinа ◽  
A. J. Novokhatnia ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Gastroesophageal Reflux Disease ◽  
Gastroesophageal Reflux ◽  
Reflux Esophagitis ◽  
Reflux Disease ◽  
Sulfanilic Acid ◽  
Control Group ◽  
Leading Position ◽  
Antireflux Barrier

Today gastroesophageal reflux disease (GERD) occupies a leading position among chronic diseases of the gastrointestinal tract. The prevalence of GERD in people with normal BMI ranges from 15 to 20%, with obesity – from 50% to 100%. The basis of GERD is a violation of the motor – evacuation function of the gastroesophageal zone, which is accompanied by a steady relaxation of the antireflux barrier. Nitric oxide (NO) plays an important role in this process. The aim of this work is to study the level of nitric oxide in patients with gastroesophageal reflux disease on the background of obesity and to assess its impact on the course of the disease. Materials and methods. The study involved 80 young people. Questionnaire was conducted using the GERDQ questionnaire, BMI, serum nitric oxide level by Griss spectrophotometric method with sulfanilic acid and 1-naphthylamine, FGDS to determine the severity of reflux esophagitis. Study participants were divided into 3 groups: patients with GERD with concomitant obesity, patients with GERD without concomitant pathology, the control group, which consisted of almost healthy individuals. Analyzing the obtained results, a significant increase in the concentration of nitric oxide in the blood of patients with GERD with concomitant obesity, compared with patients with GERD without concomitant pathology and the control group. There is a direct correlation between the level of nitric oxide in the blood and the severity of reflux esophagitis in patients with GERD with concomitant obesity. Further study of the role of nitric oxide in the pathogenesis of comorbid GERD and obesity will contribute to the development of improved methods for diagnosis, treatment and prediction of disorders.

Gastroesophageal Reflux Disease: A Gastroenterologist's Perspective

2011 ◽  
Vol 21 (3) ◽  
pp. 89-99
Author(s):  
Michael F. Vaezi
Keyword(s):  
Gastroesophageal Reflux Disease ◽  
Gastroesophageal Reflux ◽  
Reflux Disease ◽  
Best Practice ◽  
Clinical Care ◽  
Diagnostic Testing ◽  
Diagnostic Tools ◽  
Swallowing Function ◽  
Atypical Symptoms

Gastroesophageal reflux disease (GERD) is a commonly diagnosed condition often associated with the typical symptoms of heartburn and regurgitation, although it may present with atypical symptoms such as chest pain, hoarseness, chronic cough, and asthma. In most cases, the patient's reduced quality of life drives clinical care and diagnostic testing. Because of its widespread impact on voice and swallowing function as well as its social implications, it is important that speech-language pathologists (SLPs) understand the nature of GERD and its consequences. The purpose of this article is to summarize the nature of GERD and GERD-related complications such as GERD-related peptic stricture, Barrett's esophagus and adenocarcinoma, and laryngeal manifestations of GERD from a gastroenterologist's perspective. It is critical that SLPs who work with a multidisciplinary team understand terminology, diagnostic tools, and treatment to ensure best practice.

Laparoscopic antireflux surgery with routine hiatoplasty in the treatment of gastroesophageal reflux disease

2001 ◽  
Vol 120 (5) ◽  
pp. A480-A480
Author(s):  
F GRANDERATH ◽  
U SCHWEIGER ◽  
T KAMOLZ ◽  
T BAMMER ◽  
M PASIUT ◽  
...  
Keyword(s):  
Gastroesophageal Reflux Disease ◽  
Gastroesophageal Reflux ◽  
Reflux Disease ◽  
Antireflux Surgery ◽  
Laparoscopic Antireflux Surgery

One-week esomeprazole treatment; An effective contimatory test in patients with suspected gastroesophageal reflux disease

2001 ◽  
Vol 120 (5) ◽  
pp. A426-A426 ◽  
Author(s):  
F JOHNSSON ◽  
J HATTEBACK ◽  
A KLINTENBERG ◽  
J ROMAN ◽  
E TOOTH ◽  
...  
Keyword(s):  
Gastroesophageal Reflux Disease ◽  
Gastroesophageal Reflux ◽  
Reflux Disease
Sign in / Sign up

Export Citation Format

Share Document