Triggers of Coronary Plaque Rupture Syndromes

2002 ◽  
pp. 238-257
Keyword(s):  
Plaque Rupture ◽  
Coronary Plaque

scholarly journals Circulating microRNAs as potential biomarkers for coronary plaque rupture

Oncotarget ◽  
2017 ◽  
Vol 8 (29) ◽  
pp. 48145-48156 ◽  
Author(s):  
Sufang Li ◽  
Chongyou Lee ◽  
Junxian Song ◽  
Changlin Lu ◽  
Jun Liu ◽  
...  
Keyword(s):  
Plaque Rupture ◽  
Coronary Plaque ◽  
Circulating Micrornas ◽  
Potential Biomarkers

scholarly journals Impact of Coronary Plaque Vulnerability on Acute Cardiovascular Events – Design of a CT-based 2-year Follow-up Study

2019 ◽  
Vol 4 (2) ◽  
pp. 64-71
Author(s):  
Noémi Mitra ◽  
Roxana Hodas ◽  
Evelin Szabó ◽  
Zsolt Parajkó ◽  
Theodora Benedek ◽  
...  
Keyword(s):  
Cardiovascular Events ◽  
Plaque Rupture ◽  
Coronary Plaque ◽  
Plaque Vulnerability ◽  
Mortality And Morbidity ◽  
Diagnostic Strategies ◽  
Major Cardiovascular Events ◽  
Artery Disease ◽  
Improve Patient

Abstract With coronary artery disease (CAD) projected to remain the leading cause of global mortality, prevention strategies seem to be the only effective approach able to reduce the burden and improve mortality and morbidity. At this moment, diagnostic strategies focus mainly on symptomatic patients, ignoring the occurrence of major cardiovascular events as the only manifestation of CAD. As two thirds of fatal myocardial infarction are resulting from plaque rupture, an approach based on the “vulnerable plaque” concept is mandatory in order to improve patient diagnosis, treatment, and, by default, prognosis. Given that the main studies focus on a plaque-centered approach, this is a prospective observational study that will perform a complex assessment of the features that characterize unstable coronary lesions, in terms of both local assessment via specific coronary computed tomography angiography markers of coronary plaque vulnerability and systemic approach based on serological markers of systemic inflammation in patients proved to be “vulnerable” by developing acute cardiovascular events.

scholarly journals Effect of postprandial hyperglycaemia on culprit plaque rupture in diabetic patients with non-ST segment elevation acute coronary syndrome

2020 ◽  
Vol 41 (Supplement_2) ◽  
Author(s):  
G Su ◽  
S.W Zhuang ◽  
T Zhang ◽  
H.X Yang ◽  
W.L Dai ◽  
...  
Keyword(s):  
Acute Coronary Syndrome ◽  
Hemoglobin A1c ◽  
Plaque Rupture ◽  
Coronary Plaque ◽  
Postprandial Hyperglycemia ◽  
Diabetic Patients ◽  
Funding Source ◽  
St Segment Elevation ◽  
Coronary Syndrome ◽  
St Segment

Abstract Background Postprandial hyperglycemia was reported to play a key role in established risk factors of coronary artery diseases (CAD) and cardiovascular events. Serum 1,5-anhydroglucitol (1,5-AG) levels are known to be a clinical marker of postprandial hyperglycemia and short-term glycemic excursions. Low serum 1,5-AG levels have been associated with occurrence of CAD; however, the relationship between 1,5-AG levels and coronary plaque rupture has not been fully elucidated. The aim of this study was to evaluate 1,5-AG as a predictor of coronary plaque rupture in diabetic patients with non-ST segment elevation acute coronary syndrome (NSTE-ACS). Methods A total of 132 diabetic patients with NSTE-ACS were included in this study. All patients underwent intravascular ultrasound examination, which revealed 38 patients with plaque rupture and 94 patients without plaque rupture in the culprit lesion. Fasting blood glucose (FBS), hemoglobin A1c (HbA1c) and 1,5-AG levels were measured before coronary angiography. Fasting urinary 8-iso-prostaglandin F2α (8-iso-PGF2α) level was measured and corrected by creatinine clearance. Results Patients with ruptured plaque had significantly lower serum 1,5-AG levels and a tendency of higher hemoglobin A1c levels than patients without ruptured plaque in our study population. In multivariate analysis, low 1,5-AG levels were an independent predictor of plaque rupture (odds ratio 3.3; p=0.006) in diabetic patients with NSTE-ACS, but HbA1c was not. The area under the receiver-operating characteristic curve for 1,5-AG (0.678, p=0.001) to predict plaque rupture was superior to that for HbA1c (0.618, p=0.034). Levels of 1,5-AG were significantly correlated with urinary 8-iso-PGF2α (r=−0.224, p=0.010). Conclusions Postprandial hyperglycaemia appeared to be superior to long-term average blood glucose levels in predicting plaque rupture in culprit lesions, which may be useful to assess the cardiovascular outcomes in diabetic patients. Funding Acknowledgement Type of funding source: Public Institution(s). Main funding source(s): Outstanding Clinical Discipline Project of Shanghai Pudong, Beijing Health Special Foundation

Nano Monitors for Identification of Vulnerable Cardio-vascular Plaque

2006 ◽  
Vol 926 ◽  
Author(s):  
Shalini Prasad ◽  
Thomas Barrett ◽  
John Carruthers
Keyword(s):  
Complex Disease ◽  
Plaque Rupture ◽  
Coronary Plaque ◽  
Label Free ◽  
Protein Markers ◽  
Protein Biomarkers ◽  
Alumina Membrane ◽  
Non Invasive ◽  
Highly Sensitive ◽  
Cardio Vascular

AbstractWe describe highly sensitive, non–invasive, label-free, electrical detection of protein biomarkers using nanoporous alumina membrane based electrochemical conductance based devices. The principle of operation of these sensors are based on electrochemical conductance varitions associated with the binding of antibody-antigen complexes to a metallic substrate.In these devices distinct pore clusters are selectively surface functionalized with specific antibodies, that are in turn are incorporated into micro scale arrays. Protein markers were routinely detected at nanomolar concentrations. This opens the potential for developing highly sensitive and selective biomarker detection assays in clinically relevant samples for diagnosis of complex disease state like vulnerable coronary plaque rupture that results in poor post surgical outcomes and other complex diseases.

scholarly journals Comparison of Coronary Plaque Rupture Between Stable Angina and Acute Myocardial Infarction

Circulation ◽  
2004 ◽  
Vol 110 (8) ◽  
pp. 928-933 ◽  
Author(s):  
Myeong-Ki Hong ◽  
Gary S. Mintz ◽  
Cheol Whan Lee ◽  
Young-Hak Kim ◽  
Seung-Whan Lee ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Acute Myocardial Infarction ◽  
Stable Angina ◽  
Plaque Rupture ◽  
Coronary Plaque

Coronary plaque rupture in patients with myocardial infarction after noncardiac surgery: Frequent and dangerous

2012 ◽  
Vol 222 (1) ◽  
pp. 191-195 ◽  
Author(s):  
Danielle Menosi Gualandro ◽  
Carlos Augusto Campos ◽  
Daniela Calderaro ◽  
Pai Ching Yu ◽  
Andre Coelho Marques ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Plaque Rupture ◽  
Coronary Plaque ◽  
Noncardiac Surgery
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