Cytokines and Other Soluble Immune Mediators

2002 ◽  
pp. 35-47
Keyword(s):  
Immune Mediators

scholarly journals Environment‐Dependent Alterations of Immune Mediators in Urban and Rural South African Children with Atopic Dermatitis

Allergy ◽  
2021 ◽  
Author(s):  
Nonhlanhla Lunjani ◽  
Ge Tan ◽  
Anita Dreher ◽  
Milena Sokolowska ◽  
David Groeger ◽  
...  
Keyword(s):  
Atopic Dermatitis ◽  
South African ◽  
Rural South ◽  
African Children ◽  
Immune Mediators ◽  
South African Children

scholarly journals Proteomic Analysis of Synovial Fibroblasts and Articular Chondrocytes Co-Cultures Reveals Valuable VIP-Modulated Inflammatory and Degradative Proteins in Osteoarthritis

2021 ◽  
Vol 22 (12) ◽  
pp. 6441
Author(s):  
Selene Pérez-García ◽  
Valentina Calamia ◽  
Tamara Hermida-Gómez ◽  
Irene Gutiérrez-Cañas ◽  
Mar Carrión ◽  
...  
Keyword(s):  
Isotope Labeling ◽  
Articular Chondrocytes ◽  
Synovial Fibroblasts ◽  
Immune Mediators ◽  
Cartilage Extracellular Matrix ◽  
Fibronectin Fragments ◽  
Ecm Degradation ◽  
Key Events ◽  
First Time

Osteoarthritis (OA) is the most common musculoskeletal disorder causing a great disability and a reduction in the quality of life. In OA, articular chondrocytes (AC) and synovial fibroblasts (SF) release innate-derived immune mediators that initiate and perpetuate inflammation, inducing cartilage extracellular matrix (ECM) degradation. Given the lack of therapies for the treatment of OA, in this study, we explore biomarkers that enable the development of new therapeutical approaches. We analyze the set of secreted proteins in AC and SF co-cultures by stable isotope labeling with amino acids (SILAC). We describe, for the first time, 115 proteins detected in SF-AC co-cultures stimulated by fibronectin fragments (Fn-fs). We also study the role of the vasoactive intestinal peptide (VIP) in this secretome, providing new proteins involved in the main events of OA, confirmed by ELISA and multiplex analyses. VIP decreases proteins involved in the inflammatory process (CHI3L1, PTX3), complement activation (C1r, C3), and cartilage ECM degradation (DCN, CTSB and MMP2), key events in the initiation and progression of OA. Our results support the anti-inflammatory and anti-catabolic properties of VIP in rheumatic diseases and provide potential new targets for OA treatment.

scholarly journals Contributions of Electron Microscopy to Understand Secretion of Immune Mediators by Human Eosinophils

2010 ◽  
Vol 16 (6) ◽  
pp. 653-660 ◽  
Author(s):  
Rossana C.N. Melo ◽  
Ann M. Dvorak ◽  
Peter F. Weller
Keyword(s):  
Electron Microscopy ◽  
Transmission Electron Microscopy ◽  
Immune Responses ◽  
Innate Immune System ◽  
Innate Immune ◽  
Cell Secretion ◽  
The Past ◽  
Functional Capabilities ◽  
Immune Mediators ◽  
Transmission Electron

AbstractMechanisms governing secretion of proteins underlie the biologic activities and functions of human eosinophils, leukocytes of the innate immune system, involved in allergic, inflammatory, and immunoregulatory responses. In response to varied stimuli, eosinophils are recruited from the circulation into inflammatory foci, where they modulate immune responses through the release of granule-derived products. Transmission electron microscopy (TEM) is the only technique that can clearly identify and distinguish between different modes of cell secretion. In this review, we highlight the advances in understanding mechanisms of eosinophil secretion, based on TEM findings, that have been made over the past years and that have provided unprecedented insights into the functional capabilities of these cells.

Chemokines as Immune Mediators of Liver Diseases Related to the Metabolic Syndrome

2010 ◽  
Vol 28 (1) ◽  
pp. 192-196 ◽  
Author(s):  
Marie-Luise Berres ◽  
Andreas Nellen ◽  
Hermann E. Wasmuth
Keyword(s):  
Metabolic Syndrome ◽  
Liver Diseases ◽  
The Metabolic Syndrome ◽  
Immune Mediators

Houttuynia cordatamodulates oral innate immune mediators: potential role of herbal plant on oral health

Oral Diseases ◽  
2015 ◽  
Vol 21 (4) ◽  
pp. 512-518 ◽  
Author(s):  
S Satthakarn ◽  
WO Chung ◽  
A Promsong ◽  
W Nittayananta
Keyword(s):  
Oral Health ◽  
Potential Role ◽  
Innate Immune ◽  
Immune Mediators ◽  
Herbal Plant

scholarly journals Review on the Influence of Stress on Immune Mediators, Neuropeptides and Hormones with Relevance for Inflammatory Bowel Disease

Digestion ◽  
2002 ◽  
Vol 65 (3) ◽  
pp. 131-140 ◽  
Author(s):  
Jan H. Niess ◽  
Hubert Mönnikes ◽  
Axel U. Dignass ◽  
Burghard F. Klapp ◽  
Petra C. Arck
Keyword(s):  
Inflammatory Bowel Disease ◽  
Bowel Disease ◽  
Immune Mediators ◽  
Inflammatory Bowel
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