Toxicity Testing and Risk Assessment

2001 ◽  
pp. 163-182
Keyword(s):  
Risk Assessment ◽  
Toxicity Testing

The zebrafish embryo model in environmental risk assessment—applications beyond acute toxicity testing

2008 ◽  
Vol 15 (5) ◽  
pp. 394-404 ◽  
Author(s):  
Stefan Scholz ◽  
Stephan Fischer ◽  
Ulrike Gündel ◽  
Eberhard Küster ◽  
Till Luckenbach ◽  
...  
Keyword(s):  
Risk Assessment ◽  
Acute Toxicity ◽  
Environmental Risk ◽  
Environmental Risk Assessment ◽  
Zebrafish Embryo ◽  
Toxicity Testing ◽  
Acute Toxicity Testing

Hormesis - Implications for risk assessment caloric intake (body weight) as an exemplar

1998 ◽  
Vol 17 (8) ◽  
pp. 454-459 ◽  
Author(s):  
Angelo Turturro ◽  
Bruce Hass ◽  
Ronald W Hart
Keyword(s):  
Risk Assessment ◽  
Caloric Intake ◽  
Toxicity Testing ◽  
Risk Assessments ◽  
Specific Information ◽  
Response Curves ◽  
Hormetic Effect ◽  
The Impact ◽  
Hormetic Response

Hormesis can be considered as a parameter which has a non-monotonic relationship with some endpoint. Since caloric intake is such a parameter, and the impact of this parameter on risk assessment has been fairly well characterized, it can provide clues as to how to integrate the information from a hormetic parameter into risk assessments for toxicants. Based on the work with caloric intake, one could: (a) define a biomarker for hormetic effect; (b) integrate specific information on when in the animals lifespan the parameter is active to influence parameters such as survival; (c) evaluate component effects of the overall hormetic response; and (d) address the consequences of a non-monotonic relationship between the hormetic parameter and endpoints critical for risk assessment. These impacts on risk assessments have been characterized for chronic tests, but are also true for short-term tests. A priority is the characterization of the dose-response curves for hormetic parameters. This quantification will be critical in utilizing them in risk assessment. With this information, one could better quantitatively address the changes one expects to result from the hormetic parameter, and limit the uncertainty and variability which occurs in toxicity testing.

Advances in Toxicity Testing Herald Improvements and Challenges for Risk Assessment

Risk Analysis ◽  
2009 ◽  
Vol 29 (4) ◽  
pp. 490-491 ◽  
Author(s):  
Joyce S. Tsuji ◽  
Michael R. Garry
Keyword(s):  
Risk Assessment ◽  
Toxicity Testing

Toxicity Testing in the 21st Century: Implications for Human Health Risk Assessment

Risk Analysis ◽  
2009 ◽  
Vol 29 (4) ◽  
pp. 474-479 ◽  
Author(s):  
Daniel Krewski ◽  
Melvin E. Andersen ◽  
Ellen Mantus ◽  
Lauren Zeise
Keyword(s):  
Risk Assessment ◽  
Health Risk ◽  
Human Health ◽  
Health Risk Assessment ◽  
21St Century ◽  
Human Health Risk ◽  
Toxicity Testing ◽  
Human Health Risk Assessment
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