Brain abnormalities in bipolar disorder

2005 ◽  
pp. 21-25
Author(s):  
E Monkul ◽  
Jair Soares
Keyword(s):  
Bipolar Disorder ◽  
Brain Abnormalities

P.0278 Structural brain abnormalities associated with cognitive impairments in bipolar disorder

2021 ◽  
Vol 53 ◽  
pp. S201
Author(s):  
J. Macoveanu ◽  
K.O. Freeman ◽  
H.L. Kjærstad ◽  
G.M. Knudsen ◽  
L.V. Kessing ◽  
...  
Keyword(s):  
Bipolar Disorder ◽  
Cognitive Impairments ◽  
Brain Abnormalities ◽  
Structural Brain

scholarly journals The Association Between Familial Risk and Brain Abnormalities Is Disease Specific: An ENIGMA-Relatives Study of Schizophrenia and Bipolar Disorder

2019 ◽  
Vol 86 (7) ◽  
pp. 545-556 ◽  
Author(s):  
Sonja M.C. de Zwarte ◽  
Rachel M. Brouwer ◽  
Ingrid Agartz ◽  
Martin Alda ◽  
André Aleman ◽  
...  
Keyword(s):  
Bipolar Disorder ◽  
Familial Risk ◽  
Brain Abnormalities ◽  
Disease Specific

Fronto-Limbic Brain Abnormalities in Juvenile Onset Bipolar Disorder

2005 ◽  
Vol 58 (7) ◽  
pp. 525-531 ◽  
Author(s):  
Sheila C. Caetano ◽  
Rene L. Olvera ◽  
David Glahn ◽  
Manoela Fonseca ◽  
Steven Pliszka ◽  
...  
Keyword(s):  
Bipolar Disorder ◽  
Brain Abnormalities ◽  
Juvenile Onset

scholarly journals Structural brain abnormalities in bipolar disorder: what meta-analyses tell us

2010 ◽  
Vol 196 (3) ◽  
pp. 245-246 ◽  
Author(s):  
Antonio Vita ◽  
Luca De Peri ◽  
Emilio Sacchetti
Keyword(s):  
Bipolar Disorder ◽  
Brain Abnormalities ◽  
Meta Analyses ◽  
Structural Brain

Adolescents With Bipolar Disorder Have Brain Abnormalities on fMRI

2003 ◽  
Author(s):  
H. P. Blumberg ◽  
A. Martin ◽  
J. Kaufman ◽  
H. -C. Leung ◽  
P. Skudlarski ◽  
...  
Keyword(s):  
Bipolar Disorder ◽  
Brain Abnormalities

Structural brain abnormalities in patients with type I bipolar disorder and suicidal behavior

2017 ◽  
Vol 265 ◽  
pp. 9-17 ◽  
Author(s):  
Dante G.G. Duarte ◽  
Maila de Castro L. Neves ◽  
Maicon R. Albuquerque ◽  
Gustavo Turecki ◽  
Yang Ding ◽  
...  
Keyword(s):  
Bipolar Disorder ◽  
Suicidal Behavior ◽  
Type I ◽  
Brain Abnormalities ◽  
Structural Brain

Mood disorders – review of structural MRI studies

2003 ◽  
Vol 15 (6) ◽  
pp. 368-380 ◽  
Author(s):  
E. Serap Monkul ◽  
Gin S. Malhi ◽  
Jair C. Soares
Keyword(s):  
Bipolar Disorder ◽  
Mood Disorders ◽  
Unipolar Depression ◽  
Structural Mri ◽  
Common Finding ◽  
Brain Abnormalities ◽  
Prefrontal Cortical ◽  
Manual Search ◽  
Structural Abnormalities ◽  
Prospective Longitudinal

Background:Mood disorders are related to considerable morbidity and mortality, and although there is little doubt that they are brain-based disorders, their neural correlates still remain elusive. A neuro-anatomic model of mood regulation comprising the prefrontal cortex, amygdala-hippocampus complex, thalamus, basal ganglia, and connections among these areas has been proposed.Objective:We reviewed the evidence for regional brain abnormalities in bipolar disorder, and attempted to integrate available findings into a comprehensive pathophysiological model of illness.Methods:A computerized Medline Ovid search was conducted for the period 1966–2002, and complemented by a manual search of bibliographical references from recent reviews. Articles meeting specified criteria were included.Results:Hyperintense lesions in cortical and subcortical regions are the most consistently reported and widely studied structural abnormalities. Smaller prefrontal cortical volume is a common finding in bipolar disorder and unipolar depression. Enlarged amygdala (in bipolar disorder) and smaller hippocampus (in unipolar depression) have been reported by several groups. Decreased volumes (in unipolar depression) and increased or unaltered volumes (in bipolar disorder) of striatal structures have been reported.Conclusions:Bipolar and unipolar mood disorders are associated with detectable structural brain abnormalities. The histopathology underlying such anatomical changes remains to be elucidated. To reach more definitive conclusions about neuroanatomical changes that take place during the course of mood disorders, prospective longitudinal studies are needed. Also, integration with functional imaging is necessary in order to elucidate the relevance of identified structural abnormalities.

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