Hantaan Virus

2016 ◽  
pp. 677-688
Keyword(s):  
Hantaan Virus

Antigenic subunits of Hantaan virus expressed by baculovirus and vaccinia virus recombinants.

1990 ◽  
Vol 64 (7) ◽  
pp. 3162-3170 ◽  
Author(s):  
C S Schmaljohn ◽  
Y K Chu ◽  
A L Schmaljohn ◽  
J M Dalrymple
Keyword(s):  
Vaccinia Virus ◽  
Hantaan Virus

New class of hantaan virus inhibitors based on conjugation of the isoindole fragment to (+)-camphor or (−)-fenchone hydrazonesv

2021 ◽  
Vol 40 ◽  
pp. 127926
Author(s):  
Olga I. Yarovaya ◽  
Kseniya S. Kovaleva ◽  
Anna A. Zaykovskaya ◽  
Liudmila N. Yashina ◽  
Nadezda S. Scherbakova ◽  
...  
Keyword(s):  
Hantaan Virus ◽  
New Class

Elevated sICAM-1 levels in patients with hemorrhagic fever with renal syndrome caused by Hantaan virus

2010 ◽  
Vol 29 (12) ◽  
pp. 1507-1511 ◽  
Author(s):  
Qunying Han ◽  
Lei Zhang ◽  
Zhengwen Liu ◽  
Wen Kang ◽  
Sai Lou ◽  
...  
Keyword(s):  
Hemorrhagic Fever ◽  
Hantaan Virus

scholarly journals Multiplex PCR-Based Nanopore Sequencing and Epidemiological Surveillance of Hantaan orthohantavirus in Apodemus agrarius, Republic of Korea

Viruses ◽  
2021 ◽  
Vol 13 (5) ◽  
pp. 847
Author(s):  
Kyungmin Park ◽  
Seung-Ho Lee ◽  
Jongwoo Kim ◽  
Jingyeong Lee ◽  
Geum-Young Lee ◽  
...  
Keyword(s):  
Whole Genome Sequencing ◽  
Genome Sequencing ◽  
Republic Of Korea ◽  
Hantaan Virus ◽  
Genomic Sequences ◽  
Whole Genome ◽  
Nanopore Sequencing ◽  
Apodemus Agrarius ◽  
Copy Numbers ◽  
Nanopore Sequencer

Whole-genome sequencing of infectious agents enables the identification and characterization of emerging viruses. The MinION device is a portable sequencer that allows real-time sequencing in fields or hospitals. Hantaan orthohantavirus (Hantaan virus, HTNV), harbored by Apodemus agrarius, causes hemorrhagic fever with renal syndrome (HFRS) and poses a critical public health threat worldwide. In this study, we aimed to evaluate the feasibility of using nanopore sequencing for whole-genome sequencing of HTNV from samples having different viral copy numbers. Amplicon-based next-generation sequencing was performed in A. agrarius lung tissues collected from the Republic of Korea. Genomic sequences of HTNV were analyzed based on the viral RNA copy numbers. Amplicon-based nanopore sequencing provided nearly full-length genomic sequences of HTNV and showed sufficient read depth for phylogenetic analysis after 8 h of sequencing. The average identity of the HTNV genome sequences for the nanopore sequencer compared to those of generated from Illumina MiSeq revealed 99.8% (L and M segments) and 99.7% (S segment) identities, respectively. This study highlights the potential of the portable nanopore sequencer for rapid generation of accurate genomic sequences of HTNV for quicker decision making in point-of-care testing of HFRS patients during a hantavirus outbreak.

A Phase 1 clinical trial of Hantaan virus and Puumala virus M-segment DNA vaccines for hemorrhagic fever with renal syndrome

Vaccine ◽  
2012 ◽  
Vol 30 (11) ◽  
pp. 1951-1958 ◽  
Author(s):  
Ellen F. Boudreau ◽  
Matthew Josleyn ◽  
Diane Ullman ◽  
Diana Fisher ◽  
Lonnie Dalrymple ◽  
...  
Keyword(s):  
Clinical Trial ◽  
Dna Vaccines ◽  
Phase 1 ◽  
Hemorrhagic Fever ◽  
Hantaan Virus ◽  
Puumala Virus ◽  
Phase 1 Clinical Trial

scholarly journals An Efficient Method for Isolation of Hantaan Virus through Serial Passages in Suckling Mice

Intervirology ◽  
2013 ◽  
Vol 56 (3) ◽  
pp. 172-177 ◽  
Author(s):  
J.-L. Li ◽  
J.-X. Ling ◽  
L.-J. Chen ◽  
F. Wei ◽  
F. Luo ◽  
...  
Keyword(s):  
Efficient Method ◽  
Hantaan Virus ◽  
Suckling Mice

scholarly journals Peptide Antagonists That Inhibit Sin Nombre Virus and Hantaan Virus Entry through the β3-Integrin Receptor

2005 ◽  
Vol 79 (12) ◽  
pp. 7319-7326 ◽  
Author(s):  
Richard S. Larson ◽  
David C. Brown ◽  
Chunyan Ye ◽  
Brian Hjelle
Keyword(s):  
Viral Entry ◽  
Sequence Similarity ◽  
Chinese Hamster Ovary Cells ◽  
Chinese Hamster ◽  
Phage Display Library ◽  
Hantaan Virus ◽  
Sin Nombre Virus ◽  
Fab Fragment ◽  
Ovary Cells

ABSTRACT Specific therapy is not available for the treatment of hantavirus cardiopulmonary syndrome caused by Sin Nombre virus (SNV). The entry of pathogenic hantaviruses into susceptible human cells is dependent upon expression of the αvβ3 integrin, and transfection of human β3 integrin is sufficient to confer infectibility onto CHO (Chinese hamster ovary) cells. Furthermore, pretreatment of susceptible cells with anti-β3 antibodies such as c7E3 or its Fab fragment ReoPro prevents hantavirus entry. By using repeated selection of a cyclic nonamer peptide phage display library on purified αvβ3, we identified 70 peptides that were competitively eluted with ReoPro. Each of these peptides was examined for its ability to reduce the number of foci of SNV strain SN77734 in a fluorescence-based focus reduction assay according to the method of Gavrilovskaya et al. (I. N. Gavrilovskaya, M. Shepley, R. Shaw, M. H. Ginsberg, and E. R. Mackow, Proc. Natl. Acad. Sci. USA 95:7074-7079, 1998). We found that 11 peptides reduced the number of foci to a greater extent than did 80 μg/ml ReoPro when preincubated with Vero E6 cells. In addition, 8 of the 70 peptides had sequence similarity to SNV glycoproteins. We compared all 18 peptide sequences (10 most potent, 7 peptides with sequence similarity to hantavirus glycoproteins, and 1 peptide that was in the group that displayed the greatest potency and had significant sequence similarity) for their abilities to inhibit SNV, Hantaan virus (HTNV), and Prospect Hill virus (PHV) infection. There was a marked trend for the peptides to inhibit SNV and HTNV to a greater extent than they inhibited PHV, a finding that supports the contention that SNV and HTNV use β3 integrins and PHV uses a different receptor, β1 integrin. We then chemically synthesized the four peptides that showed the greatest ability to neutralize SNV. These peptides inhibited viral entry in vitro as free peptides outside of the context of a phage. Some combinations of peptides proved more inhibitory than did individual peptides. In all, we have identified novel peptides that inhibit entry by SNV and HTNV via β3 integrins and that can be used as lead compounds for further structural optimization and consequent enhancement of activity.

scholarly journals A Case of Graves' Disease Combined with Hantaan Virus Infection

2009 ◽  
Vol 24 (1) ◽  
pp. 158 ◽  
Author(s):  
Heung Yong Jin ◽  
Seon Mee Kang ◽  
So Young Kim ◽  
Ji Hyun Park ◽  
Hong Sun Baek ◽  
...  
Keyword(s):  
Virus Infection ◽  
Hantaan Virus ◽  
Graves Disease
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