Intrapartum antibiotic prophylaxis for group B streptococci

2010 ◽  
pp. 210-211
Author(s):  
Leroy C Edozien
Keyword(s):  
Antibiotic Prophylaxis ◽  
Group B Streptococci ◽  
Intrapartum Antibiotic Prophylaxis ◽  
Intrapartum Antibiotic ◽  
Group B

scholarly journals Removal of Group B Streptococci Colonizing the Vagina and Oropharynx of Mice with a Bacteriophage Lytic Enzyme

2005 ◽  
Vol 49 (1) ◽  
pp. 111-117 ◽  
Author(s):  
Qi Cheng ◽  
Daniel Nelson ◽  
Shiwei Zhu ◽  
Vincent A. Fischetti
Keyword(s):  
Antibiotic Prophylaxis ◽  
Pregnant Women ◽  
Bacterial Colonization ◽  
Lytic Enzyme ◽  
Neonatal Meningitis ◽  
Group B Streptococci ◽  
Intrapartum Antibiotic Prophylaxis ◽  
Intrapartum Antibiotic ◽  
Group B

ABSTRACT Group B streptococci (GBS) are the leading cause of neonatal meningitis and sepsis worldwide. The current treatment strategy is limited to intrapartum antibiotic prophylaxis in pregnant women to prevent early-onset neonatal diseases, but considering the potential for antibiotic resistance, the risk of losing control over the disease is high. To approach this problem, we have developed a bacteriophage (phage) lytic enzyme to remove colonizing GBS. Bacteriophage muralytic enzymes, termed lysins, are highly evolved molecules designed to degrade the cell wall of host bacteria to release phage particles from the bacterial cytoplasm. Several different lysins have been developed to specifically kill bacterial pathogens both on mucosal surfaces and in blood and represent a novel approach to control infection. A lysin cloned from a phage infecting GBS was found to contain two putative catalytic domains and one putative binding domain, which is similar to the domain organization of some staphylococcal phage lysins. The lysin (named PlyGBS) was recombinantly expressed in Escherichia coli, and purified PlyGBS efficiently killed all tested GBS serotypes in vitro. In a mouse model, a single dose of PlyGBS significantly reduced bacterial colonization in both the vagina and oropharynx. As an alternative strategy for intrapartum antibiotic prophylaxis, this approach may be used to reduce vaginal GBS colonization in pregnant women before delivery or to decontaminate newborns, thus reducing the incidence of GBS-associated neonatal meningitis and sepsis.

Effects of Intrapartum Antibiotic Prophylaxis on Neonatal Acquisition of Group B Streptococci

2017 ◽  
Vol 190 ◽  
pp. 169-173.e1 ◽  
Author(s):  
Meiwa Toyofuku ◽  
Miyuki Morozumi ◽  
Mariko Hida ◽  
Yoshitake Satoh ◽  
Hiroshi Sakata ◽  
...  
Keyword(s):  
Antibiotic Prophylaxis ◽  
Group B Streptococci ◽  
Intrapartum Antibiotic Prophylaxis ◽  
Intrapartum Antibiotic ◽  
Group B

scholarly journals A study of the prevalence of group B streptococci in the third trimester of pregnancy

2019 ◽  
Vol 8 (10) ◽  
pp. 3911
Author(s):  
Vikas Tambe ◽  
Versha Shokeen ◽  
Himadri Bal ◽  
Ajita Mishra
Keyword(s):  
Antibiotic Prophylaxis ◽  
Neonatal Sepsis ◽  
Cross Sectional Study ◽  
Third Trimester ◽  
Group B Streptococci ◽  
Cross Sectional ◽  
Intrapartum Antibiotic Prophylaxis ◽  
Key Factor ◽  
Intrapartum Antibiotic ◽  
Group B

Background: Group B Streptococci (GBS) is an important cause of early onset neonatal sepsis and the maternal colonization of this organism is a key factor in the occurrence of GBS associated morbidity and mortality in the newborns. Timely recognition of its presence in the genital tract of a pregnant women and intrapartum antibiotic prophylaxis can significantly bring down the burden of the disease in neonates. A cross sectional study was conducted on  antenatal women during 35-37weeks of gestation to evaluate the prevalence of Group B Streptococci in third trimester of pregnancy and explore the feasibility of including GBS screening in the routine antenatal investigation protocol.Methods: 200 antenatal women satisfying the exclusion/inclusion criteria were recruited for the study. Vaginal and perianal swabs were collected using sterile swab sticks and inoculated using the specified media. Beta hemolysis and typical colonies were looked for under microscope. Positive cases were subjected to intrapartum antibiotic prophylaxis and the neonates were observed for 72 hours to look for any signs of sepsis.Results: It was found that 2% of the women screened were positive for GBS .While none of the newborns of the 4 positive cases showed any signs of sepsis.Conclusions: Prophylactic intrapartum prophylaxis against GBS has shown to decrease the chances of neonatal sepsis but more detailed and robust studies are required before incorporating routine screening in our antenatal care system.

Avoiding Inadequate Intrapartum Antibiotic Prophylaxis for Group B Streptococci

2016 ◽  
Vol 128 (3) ◽  
pp. 598-603 ◽  
Author(s):  
Sarah Bienenfeld ◽  
Laura G. Rodriguez-Riesco ◽  
Kent D. Heyborne
Keyword(s):  
Antibiotic Prophylaxis ◽  
Group B Streptococci ◽  
Intrapartum Antibiotic Prophylaxis ◽  
Intrapartum Antibiotic ◽  
Group B
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