Thromboembolism prophylaxis

2010 ◽  
pp. 169-172
Author(s):  
Leroy C Edozien
Keyword(s):  
Thromboembolism Prophylaxis

Impact of Weight-Band Dosing of Tinzaparin for Venous Thromboembolism Prophylaxis on Persistent Wound Drainage in Adult Patients Undergoing Hip and Knee Arthroplasty

2021 ◽  
pp. 106002802110242
Author(s):  
Cassandra Cooper ◽  
Ouida Antle ◽  
Jennifer Lowerison ◽  
Deonne Dersch-Mills ◽  
Ashley Kenny
Keyword(s):  
Body Weight ◽  
Venous Thromboembolism ◽  
Knee Arthroplasty ◽  
Total Joint Arthroplasty ◽  
Joint Arthroplasty ◽  
Thromboembolism Prophylaxis ◽  
Wound Drainage ◽  
Increased Risk ◽  
Significant Difference ◽  
The Impact

Background: Persistent wound drainage and venous thromboembolism (VTE) are potential complications of total joint arthroplasty, and these risks can be challenging to balance in clinical practice. Anecdotal observation has suggested that following joint arthroplasty, persistent wound drainage occurs more frequently with higher body weight and higher doses of tinzaparin when compared with lower body weight and lower doses of tinzaparin. Objective: The overall purpose of this study was to describe the impact of a tinzaparin weight-band dosing table for VTE prophylaxis on wound healing, thrombosis, and bleeding outcomes in patients undergoing total joint arthroplasty. Methods: This retrospective chart review included patients who underwent total hip or knee arthroplasty and received tinzaparin for thromboprophylaxis per their weight-banding category. The primary outcome was the incidence of persistent wound drainage. Secondary outcomes include the occurrence of VTE and clinically important bleeding during hospital admission. Results: A total of 231 patients were included in the analysis. There was no significant difference in persistent wound drainage between the 3 weight categories, and there were no differences in rates of VTE or clinically important bleeding. Concurrent use of low-dose acetylsalicylic acid was associated with a 3-fold increased risk of persistent wound drainage (risk ratio = 3.35; 95% CI = 2.14-5.24; P = 0.00003). Conclusion and Relevance: In joint arthroplasty patients, we observed no significant difference in rates of persistent wound drainage between various weight categories receiving different weight-banded doses of tinzaparin. Our results do not suggest that the current weight-band dosing table for tinzaparin needs to be adjusted to optimize patient outcomes.

Letter: Commentary: What We Might or Might Not Know About Venous Thromboembolism Prophylaxis in Neurosurgery

Neurosurgery ◽  
2021 ◽  
Author(s):  
Paul Nyquist ◽  
Fernando Goldenberg ◽  
Cynthia Bautista ◽  
Benjamin Miller ◽  
Draga Jichici ◽  
...  
Keyword(s):  
Venous Thromboembolism ◽  
Thromboembolism Prophylaxis ◽  
Venous Thromboembolism Prophylaxis

scholarly journals No Difference Between Low- and Regular-dose Aspirin for Venous Thromboembolism Prophylaxis After THA

2019 ◽  
Vol 477 (2) ◽  
pp. 396-402 ◽  
Author(s):  
Mhamad Faour ◽  
Nicolas S. Piuzzi ◽  
David P. Brigati ◽  
Alison K. Klika ◽  
Michael A. Mont ◽  
...  
Keyword(s):  
Venous Thromboembolism ◽  
Thromboembolism Prophylaxis ◽  
Venous Thromboembolism Prophylaxis ◽  
Dose Aspirin
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