Robotics, laryngeal transplantation, gene therapy, growth factors and facial transplantation

Stell and Maran's Textbook of Head and Neck Surgery and Oncology Fifth edition ◽

10.1201/b13389-69 ◽

2012 ◽

pp. 1099-1112

Author(s):

David Grant ◽

Michael Hinni ◽

Martin Birchall

Keyword(s):

Gene Therapy ◽

Growth Factors ◽

Facial Transplantation

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Growth Factor Therapy for Parkinson’s Disease: Alternative Delivery Systems

Journal of Parkinson s Disease ◽

10.3233/jpd-212662 ◽

2021 ◽

pp. 1-7

Author(s):

Sarah Jarrin ◽

Abrar Hakami ◽

Ben Newland ◽

Eilís Dowd

Keyword(s):

Parkinson’S Disease ◽

Gene Therapy ◽

Parkinson's Disease ◽

Growth Factors ◽

Growth Factor ◽

Ex Vivo ◽

Brain Regions ◽

Delivery Systems ◽

Alternative Delivery

Despite decades of research and billions in global investment, there remains no preventative or curative treatment for any neurodegenerative condition, including Parkinson’s disease (PD). Arguably, the most promising approach for neuroprotection and neurorestoration in PD is using growth factors which can promote the growth and survival of degenerating neurons. However, although neurotrophin therapy may seem like the ideal approach for neurodegenerative disease, the use of growth factors as drugs presents major challenges because of their protein structure which creates serious hurdles related to accessing the brain and specific targeting of affected brain regions. To address these challenges, several different delivery systems have been developed, and two major approaches—direct infusion of the growth factor protein into the target brain region and in vivo gene therapy—have progressed to clinical trials in patients with PD. In addition to these clinically evaluated approaches, a range of other delivery methods are in various degrees of development, each with their own unique potential. This review will give a short overview of some of these alternative delivery systems, with a focus on ex vivo gene therapy and biomaterial-aided protein and gene delivery, and will provide some perspectives on their potential for clinical development and translation.

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Growth factor gene therapy for Alzheimer disease

Neurosurgical FOCUS ◽

10.3171/foc.2002.13.5.6 ◽

2002 ◽

Vol 13 (5) ◽

pp. 1-5 ◽

Cited By ~ 12

Author(s):

Mark H. Tuszynski ◽

Hoi Sang U ◽

John Alksne ◽

Roy A. Bakay ◽

Mary Margaret Pay ◽

...

Keyword(s):

Gene Therapy ◽

Nervous System ◽

Growth Factors ◽

Growth Factor ◽

Alzheimer Disease ◽

Neuronal Degeneration ◽

Significant Advance ◽

Factor Gene ◽

Growth Factor Gene ◽

Effective Manner

The capacity to prevent neuronal degeneration and death during the course of progressive neurological disorders such as Alzheimer disease (AD) would represent a significant advance in therapy. Nervous system growth factors are families of naturally produced proteins that, in animal models, exhibit extensive potency in preventing neuronal death due to a variety of causes, reversing age-related atrophy of neurons, and ameliorating functional deficits. The main challenge in translating growth factor therapy to the clinic has been delivery of growth factors to the brain in sufficient concentrations to influence neuronal function. One means of achieving growth factor delivery to the central nervous system in a highly targeted, effective manner may be gene therapy. In this article the authors summarize the development and implementation of nerve growth factor gene delivery as a potential means of reducing cell loss in AD.

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PHYSICAL EXERCISE IN THE PROMOTION OF GENE THERAPY AUXILIARY EFFECT

Revista Brasileira de Medicina do Esporte ◽

10.1590/1517-8692202127082021_0360 ◽

2021 ◽

Vol 27 (8) ◽

pp. 779-782

Author(s):

Wei Shen ◽

Xiaojun Liang

Keyword(s):

Gene Therapy ◽

Growth Factors ◽

Growth Factor ◽

Physical Exercise ◽

Fracture Healing ◽

Bone Morphogenetic Protein ◽

Bone Growth ◽

Transforming Growth Factor ◽

Transforming Growth Factors ◽

Morphogenetic Protein

ABSTRACT Introduction: In recent years, genetic engineering has made outstanding contributions to sports, and it has played a huge role in promoting the development of sports-related fields. Objective: We analyze the tissue source of bone growth and healing by studying the role of bone morphogenetic protein and transforming growth factors in fracture injuries caused by sports. Methods: We established a human fracture model to express the shape and content of bone morphogenetic protein and transforming growth factor during fracture healing. Results: In the fracture healing stage caused by different sports, the expression levels of the two genes are different. Bone morphogenetic protein has a high content in the osteogenesis stage of the membrane, while transforming growth factor is high in the cartilage ossification stage. Conclusion: Gene therapy for fractures caused by physical exercise has certain advantages. Osteoblasts and chondrocytes are involved in the synthesis of transforming growth factors. Level of evidence II; Therapeutic studies - investigation of treatment results.

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