scholarly journals Gastro-oesophageal reflux disease (GORD)

2009 ◽  
pp. 128-141
Keyword(s):  
Reflux Disease ◽  
Oesophageal Reflux ◽  
Oesophageal Reflux Disease

Gastro-oesophageal reflux disease

The Lancet ◽  
2006 ◽  
Vol 367 (9528) ◽  
pp. 2086-2100 ◽  
Author(s):  
Paul Moayyedi ◽  
Nicholas J Talley
Keyword(s):  
Reflux Disease ◽  
Oesophageal Reflux ◽  
Oesophageal Reflux Disease

scholarly journals The association between gastro-oesophageal reflux disease and subsequent rheumatoid arthritis occurrence: a nested case–control study from Taiwan

BMJ Open ◽  
2017 ◽  
Vol 7 (11) ◽  
pp. e016667 ◽  
Author(s):  
Herng-Ching Lin ◽  
Sudha Xirasagar ◽  
Cha-Ze Lee ◽  
Chung-Chien Huang ◽  
Chao-Hung Chen
Keyword(s):  
Rheumatoid Arthritis ◽  
Early Diagnosis ◽  
Reflux Disease ◽  
Treatment Guidelines ◽  
Population Based ◽  
Oesophageal Reflux ◽  
Study Patient ◽  
Oesophageal Reflux Disease ◽  
Increased Risk

ObjectiveGastro-oesophageal reflux disease (GORD) is a common comorbidity among patients with rheumatoid arthritis (RA). While GORD has been attributed to the antirheumatic medications, no studies of human cohorts have investigated a link between GORD and RA. This study investigates whether GORD is associated with a subsequent RA diagnosis over a 5-year follow-up using a population-based dataset.SettingTaiwanParticipantsWe used data from the Taiwan Longitudinal Health Insurance Database. The study group consisted of 13 645 patients with an ambulatory claim showing a GORD diagnosis. We used propensity score matching to select 13 645 comparison patients (one per study patient with GORD).InterventionWe tracked each patient’s claims over a 5-year period to identify those who subsequently received a diagnosis of RA. Cox proportional hazard (PH) regression modelling was used for analysis.ResultsOver 5-year follow-up, RA incidence rate per 1000 person-years was 2.81 among patients with GORD and 0.84 among the comparison group. Cox PH modelling showed that GORD was independently associated with a 2.84-fold increased risk of RA (95% CI 2.09 to 3.85) over 5-year follow-up, after adjusting for the number of ambulatory care visits within the year following the index date (to mitigate surveillance bias).ConclusionsWe observed that GORD might associate with subsequent RA occurrence. Because current treatment guidelines for RA emphasise early diagnosis and prompt treatment, the observed association between GORD and RA may help acquaint clinicians to patients with GORD with higher RA risk and facilitate early diagnosis and treatment.

Gastro-oesophageal reflux disease

The Lancet ◽  
2000 ◽  
Vol 356 (9223) ◽  
pp. 72-73 ◽  
Author(s):  
HG Gooszen
Keyword(s):  
Reflux Disease ◽  
Oesophageal Reflux ◽  
Oesophageal Reflux Disease
Sign in / Sign up

Export Citation Format

Share Document