Bronchoalveolar lavage in drug-induced lung disease

2010 ◽  
pp. 32-42 ◽  
Author(s):  
Francesco Bonella ◽  
Esra Uzaslan ◽  
Josune Guzman ◽  
Ulrich Costabel
Keyword(s):  
Bronchoalveolar Lavage ◽  
Lung Disease ◽  
Drug Induced

Bronchoalveolar lavage in drug-induced lung disease

2004 ◽  
Vol 25 (1) ◽  
pp. 25-35 ◽  
Author(s):  
Ulrich Costabel ◽  
Esra Uzaslan ◽  
Josune Guzman
Keyword(s):  
Bronchoalveolar Lavage ◽  
Lung Disease ◽  
Drug Induced

Granulomatous Reaction to Pneumocystis jirovecii Diagnosed in a Bronchoalveolar Lavage: A Case Report

2015 ◽  
Vol 59 (3) ◽  
pp. 284-288 ◽  
Author(s):  
Antoine Nobile ◽  
Antonio Valenti ◽  
John-David Aubert ◽  
Catherine Beigelman ◽  
Igor Letovanec ◽  
...  
Keyword(s):  
Bronchoalveolar Lavage ◽  
Lung Disease ◽  
Lung Biopsy ◽  
Hematological Malignancies ◽  
Pathological Finding ◽  
Open Lung Biopsy ◽  
Pneumocystis Jirovecii ◽  
Granulomatous Reaction ◽  
Rapid Improvement ◽  
Drug Induced

Background: Granulomatous reaction to Pneumocystis jirovecii is a rare but well-known pathological finding encountered in the setting of immunosuppression, HIV infection being the most common cause. It can also potentially complicate the treatment of hematological malignancies, typically when drugs lowering the count and function of lymphocytes are used. Lung biopsy is considered the gold standard for the diagnosis of granulomatous P. jirovecii pneumonia, whereas the diffuse alveolar form is usually detected cytologically in bronchoalveolar lavage (BAL). Case: A female patient pursuing R-CHOP chemotherapy for the treatment of multiple hematological malignancies developed a rapidly progressing dyspnea. Chest CT scans revealed a worsening of a known infiltrative lung disease thought to be secondary to her chemotherapy. Alterations compatible with a drug-induced interstitial lung disease and well-formed focally necrotizing granulomas were observed on an open lung biopsy, but no microorganism was identified with special stains. Eventually, a granulomatous reaction to P. jirovecii was found in a BAL and allowed appropriate treatment with rapid improvement of the dyspnea. Conclusion: Because granulomas are tissue-bound structures, they are rarely described in BAL. This article describes the first reported cytological diagnosis of a granulomatous reaction to P. jirovecii and the potential diagnostic interest of such a peculiar finding.

scholarly journals Serum Metabolomic Profiles of Rheumatoid Arthritis Patients With Acute-Onset Diffuse Interstitial Lung Disease

2019 ◽  
Vol 14 ◽  
pp. 117727191987047 ◽  
Author(s):  
Hiroshi Furukawa ◽  
Shomi Oka ◽  
Kota Shimada ◽  
Atsushi Hashimoto ◽  
Akiko Komiya ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Interstitial Lung Disease ◽  
Lung Disease ◽  
Stable State ◽  
Area Under The Curve ◽  
Stable Condition ◽  
Hierarchical Cluster ◽  
Acute Onset ◽  
Serum Samples ◽  
Drug Induced

Objective: Acute-onset diffuse interstitial lung disease (AoDILD) includes acute exacerbation of interstitial lung disease (ILD), drug-induced ILD, and Pneumocystis pneumonia, and frequently occurs in patients with rheumatoid arthritis (RA). Since AoDILD causes a poor prognosis in RA, biomarkers for AoDILD were eagerly desired. Metabolomic analyses were extensively performed in cancer patients and successfully generated better diagnostic biomarkers. In the present study, serum metabolomic profiles of AoDILD in RA were investigated to generate better potential metabolomic biomarkers. Methods: Serum samples of 10 RA patients with AoDILD were collected on admission and in a stable state, more than 3 months before the admission. Serum metabolomic analyses were conducted on the samples from these RA patients with AoDILD. Results: Apparently distinct serum metabolomic profiles in AoDILD were not observed in univariate or hierarchical cluster analyses. Partial least squares-discriminant analysis (PLS-DA) was performed to select candidate metabolites based on variable importance in projection (VIP) scores. The PLS-DA model generated from the four metabolites with VIP scores more than 2.25 (mannosamine, alliin, kynurenine, and 2-hydroxybutyric acid) could successfully discriminate AoDILD from the stable condition (area under the curve: 0.962, 95% confidence interval: 0.778–1.000). Conclusion: It was demonstrated that metabolomic profiling was useful to generate better biomarkers in AoDILD.

Cytochrome P450 polymorphisms and drug-induced interstitial lung disease

2011 ◽  
Vol 7 (12) ◽  
pp. 1547-1560 ◽  
Author(s):  
Martin Schwaiblmair ◽  
Werner Behr ◽  
Wolfgang Foerg ◽  
Thomas Berghaus
Keyword(s):  
Cytochrome P450 ◽  
Interstitial Lung Disease ◽  
Lung Disease ◽  
Drug Induced

Development of an Air-Fluid Level after Bronchoalveolar Lavage in Fibrocystic Lung Disease

CHEST Journal ◽  
1991 ◽  
Vol 100 (6) ◽  
pp. 1743-1744
Author(s):  
Petre C. Hill ◽  
Monte A. Herman ◽  
Prashant Kumar Rohatgi
Keyword(s):  
Bronchoalveolar Lavage ◽  
Lung Disease ◽  
Fluid Level

scholarly journals Drug-Induced Interstitial Lung Disease from a Misdiagnosed Infection

2018 ◽  
Vol 11 ◽  
pp. 117863611879837
Author(s):  
Patrick Twohig ◽  
Jaclyn Rivington
Keyword(s):  
Interstitial Lung Disease ◽  
Lung Disease ◽  
Drug Induced
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