Inherited Cancer Syndromes

Family Practice News ◽

10.1016/s0300-7073(07)71097-6 ◽

2007 ◽

Vol 37 (17) ◽

pp. 42

Author(s):

GREG FEERO

Keyword(s):

Inherited Cancer ◽

Cancer Syndromes

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Book Review Inherited Cancer Syndromes: Current Clinical Management Edited by C. Neal Ellis. 552 pp. New York, Springer-Verlag, 2004. $69. 0-387-40246-2

New England Journal of Medicine ◽

10.1056/nejm200411113512026 ◽

2004 ◽

Vol 351 (20) ◽

pp. 2137-2138

Author(s):

Randall W. Burt

Keyword(s):

New York ◽

Clinical Management ◽

Inherited Cancer ◽

Cancer Syndromes

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Trends in use of bilateral prophylactic mastectomy vs high-risk surveillance in unaffected carriers of inherited breast cancer syndromes in the Inherited Cancer Registry (ICARE)

Breast Cancer Research and Treatment ◽

10.1007/s10549-018-5057-7 ◽

2018 ◽

Vol 174 (1) ◽

pp. 39-45 ◽

Cited By ~ 3

Author(s):

Danielle A. Henry ◽

Marie C. Lee ◽

Deanna Almanza ◽

Kamran A. Ahmed ◽

Weihong Sun ◽

...

Keyword(s):

Breast Cancer ◽

High Risk ◽

Cancer Registry ◽

Prophylactic Mastectomy ◽

Inherited Cancer ◽

Bilateral Prophylactic Mastectomy ◽

Inherited Breast Cancer ◽

Cancer Syndromes

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Oral Cancer-related Inherited Cancer Syndromes: A Comprehensive Review

The Journal of Contemporary Dental Practice ◽

10.5005/jp-journals-10024-1880 ◽

2016 ◽

Vol 17 (6) ◽

pp. 504-510 ◽

Cited By ~ 11

Author(s):

Akshit Batra ◽

Sujata Yerawadekar

Keyword(s):

Oral Cancer ◽

Genetic Disorders ◽

Genetic Mutation ◽

Oral Potentially Malignant Disorders ◽

Comprehensive Review ◽

Li Fraumeni Syndrome ◽

Inherited Cancer ◽

Dental Practitioners ◽

Potentially Malignant ◽

Cancer Syndromes

ABSTRACT Oral squamous cell carcinoma is the most common malignancy of the oral cavity, which is usually preceded by a myriad of oral potentially malignant disorders (OPMDs). In the classification of OPMDs, inherited cancer syndromes (ICSs) were proposed as one of the categories. Inherited cancer syndromes are genetic disorders in which inherited genetic mutation in one or more genes predispose the affected individuals to the development of cancer and may also cause its early onset. Many of these syndromes are caused by mutations in tumor suppressor genes, oncogenes, and genes involved in angiogenesis. General dental practitioners frequently come across OPMDs in their day-to-day practice. It becomes of paramount importance to have knowledge about these rare but prognostically important OPMDs. With this view in mind, in this article, efforts have been made to comprehensively discuss about various ICSs that have higher potential of transformation into oral cancer. The ICSs discussed in this article are xeroderma pigmentosum (XP), ataxia telangiectasia (AT), Bloom syndrome (BS), Fanconi's anemia (FA), and Li–Fraumeni syndrome (LFS), with special emphasis on signs, symptoms, and genetic considerations. How to cite this article Sarode GS, Batra A, Sarode SC, Yerawadekar S, Patil S. Oral Cancer-related Inherited Cancer Syndromes: A Comprehensive Review. J Contemp Dent Pract 2016;17(6):504-510.

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“Comment on: S.S. Prime et al. ‘A review of inherited cancer syndromes and their relevance to oral squamous cell carcinoma’ Oral Oncology 2001; 37(1) 1–16” by A. Patrikidou, M. Harris, J. Bennett, P. Abou-Sleiman, J.D.A. Delhanty

Oral Oncology ◽

10.1016/s1368-8375(02)00016-7 ◽

2002 ◽

Vol 38 (4) ◽

pp. 405

Keyword(s):

Squamous Cell Carcinoma ◽

Oral Squamous Cell Carcinoma ◽

Cell Carcinoma ◽

Squamous Cell ◽

Inherited Cancer ◽

Oral Oncology ◽

Cancer Syndromes

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Surveillance of Individuals with a Family History of Pancreatic Cancer and Inherited Cancer Syndromes: A Strategy for Detecting Early Pancreatic Cancers

Diagnostics ◽

10.3390/diagnostics9040169 ◽

2019 ◽

Vol 9 (4) ◽

pp. 169

Author(s):

Matsubayashi ◽

Kiyozumi ◽

Ishiwatari ◽

Uesaka ◽

Kikuyama ◽

...

Keyword(s):

Pancreatic Cancer ◽

Family History ◽

Early Stage ◽

Developed Countries ◽

Familial Pancreatic Cancer ◽

Cancer Syndrome ◽

Inherited Cancer ◽

Clinicopathological Findings ◽

History Of ◽

Cancer Syndromes

A family history of pancreatic cancer (PC) is a risk factor of PC, and risk levels increase as affected families grow in number and/or develop PC at younger ages. Familial pancreatic cancer (FPC) is defined as a client having at least two PC cases in a first degree relatives. In the narrow sense, FPC does not include some inherited cancer syndromes that are known to increase the risks of PC, such as Peutz–Jeghers syndrome (PJS), hereditary pancreatitis (HP), hereditary breast ovarian cancer syndrome (HBOC), and so on. FPC accounts for 5%–10% of total PC diagnoses and is marked by several features in genetic, epidemiological, and clinicopathological findings that are similar to or distinct from conventional PC. Recent advances in genetic medicine have led to an increased ability to identify germline variants of cancer-associated genes. To date, high-risk individuals (HRIs) in many developed countries, including FPC kindreds and inherited cancer syndromes, are screened clinically to detect and treat early-stage PC. This article highlights the concept of FPC and the most recent data on its detection.

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