Familial ovarian cancer

2004 ◽  
pp. 303-314
Author(s):  
Paul Pharoah ◽  
Bruce Ponder
Keyword(s):  
Ovarian Cancer ◽  
Familial Ovarian Cancer

The Tubal Fimbria Is a Preferred Site for Early Adenocarcinoma in Women With Familial Ovarian Cancer Syndrome

2006 ◽  
Vol 30 (2) ◽  
pp. 230-236 ◽  
Author(s):  
Fabiola Medeiros ◽  
Michael G Muto ◽  
Yonghee Lee ◽  
Julia A Elvin ◽  
Michael J Callahan ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Cancer Syndrome ◽  
Familial Ovarian Cancer ◽  
Early Adenocarcinoma

scholarly journals Variants in the Signaling Protein TSAd are Associated with Susceptibility to Ovarian Cancer in BRCA1/2 Negative High Risk Families

2012 ◽  
Vol 7 ◽  
pp. BMI.S10815 ◽  
Author(s):  
Ludmila Kaplun ◽  
Aviva Levine Fridman ◽  
Wei Chen ◽  
Nancy K. Levin ◽  
Sidra Ahsan ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
High Risk ◽  
Cancer Risk ◽  
Allelic Variation ◽  
High Risk Population ◽  
Ovarian Cancer Risk ◽  
Familial Ovarian Cancer ◽  
Cell Growth And Differentiation ◽  
Brca1 Brca2 ◽  
High Risk Families

A substantial fraction of familial ovarian cancer cases cannot be attributed to specific genetic factors. The discovery of additional susceptibility genes will permit a more accurate assessment of hereditary cancer risk and allow for monitoring of predisposed women in order to intervene at the earliest possible stage. We focused on a population with elevated familial breast and ovarian cancer risk. In this study, we identified a SNP rs926103 whose minor allele is associated with predisposition to ovarian but not breast cancer in a Caucasian high-risk population without BRCA1/ BRCA2 mutations. We have found that the allelic variation of rs926103, which alters amino acid 52 of the encoded protein SH2D2A/TSAd, results in differences in the activity of this protein involved in multiple signal transduction pathways, including regulation of immune response, tumor vascularization, cell growth, and differentiation. Our observation provides a novel candidate genetic biomarker of elevated ovarian cancer risk in members of high-risk families without BRCA1/2 mutations, as well as a potential therapeutic target, TSAd.

Catalysts to withdrawal from familial ovarian cancer screening for surgery and reactions to discontinued screening: a qualitative study

2012 ◽  
Vol 12 (1) ◽  
pp. 19-26 ◽  
Author(s):  
Kate J. Lifford ◽  
Alison Clements ◽  
Lindsay Fraser ◽  
Deborah Lancastle ◽  
Kate Brain
Keyword(s):  
Ovarian Cancer ◽  
Cancer Screening ◽  
Qualitative Study ◽  
Ovarian Cancer Screening ◽  
Familial Ovarian Cancer

scholarly journals Transmission of X-linked Ovarian Cancer: Characterization and Implications

Diagnostics ◽  
2020 ◽  
Vol 10 (2) ◽  
pp. 90
Author(s):  
John Lewis Etter ◽  
Kirsten Moysich ◽  
Shaun Kohli ◽  
Shashikant Lele ◽  
Kunle Odunsi ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
X Chromosome ◽  
Risk Allele ◽  
Significant Proportion ◽  
Distinct Pattern ◽  
Future Studies ◽  
Independent Locus ◽  
Familial Ovarian Cancer ◽  
Novel Target ◽  
Allele Transmission

We recently reported evidence that a strong, BRCA-independent locus on the X-chromosome may contribute to ovarian cancer predisposition in families ascertained from the Familial Ovarian Cancer Registry (Buffalo, NY, USA). While it has been estimated that approximately 20% of all ovarian cancer cases are hereditary, it is possible that a significant proportion of cases previously believed to be sporadic may, in fact, be X-linked. Such X-linked disease has a distinct pattern; it implies that a father will necessarily pass a risk allele to each of his daughters, increasing the prevalence of cancers clustered within a family. X-chromosome inactivation further influences the expression of X-linked alleles and may represent a novel target for screening and therapy. Herein, we review the current literature regarding X-linked ovarian cancer and interpret allele transmission-based models to characterize X-linked ovarian cancer and develop a framework for clinical and epidemiological familial ascertainment to inform the design of future studies.

Use of family history in a screening clinic for familial ovarian cancer

1992 ◽  
Vol 47 (2) ◽  
pp. 247-252 ◽  
Author(s):  
R. Houlston ◽  
T.H. Bourne ◽  
A. Davies ◽  
M.I. Whitehead ◽  
S. Campbell ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Family History ◽  
Familial Ovarian Cancer ◽  
Screening Clinic

Correlation in ages at death from familial ovarian cancer among sisters

1992 ◽  
Vol 47 (2) ◽  
pp. 253-254 ◽  
Author(s):  
Richard S. Houlston ◽  
Jayne Hampson ◽  
William P. Collins ◽  
Malcolm I. Whitehead ◽  
Stuart Campbell ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Familial Ovarian Cancer

A qualitative study of women's experiences of familial ovarian cancer screening

2013 ◽  
Vol 22 (11) ◽  
pp. 2576-2584 ◽  
Author(s):  
Kate J. Lifford ◽  
Alison Clements ◽  
Lindsay Fraser ◽  
Deborah Lancastle ◽  
Kate Brain ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Cancer Screening ◽  
Qualitative Study ◽  
Ovarian Cancer Screening ◽  
Women’S Experiences ◽  
Women's Experiences ◽  
Familial Ovarian Cancer
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