Wilms tumour and other childhood renal tumours

2003 ◽  
pp. 141-153 ◽  
Keyword(s):  
Wilms Tumour ◽  
Renal Tumours

Imaging of Solid Kidney Tumours in Children

1995 ◽  
Vol 36 (3) ◽  
pp. 254-260 ◽  
Author(s):  
C. Hugosson ◽  
R. Nyman ◽  
B. Jacobsson ◽  
H. Jorulf ◽  
K. Sackey ◽  
...  
Keyword(s):  
Mr Imaging ◽  
Clear Cell ◽  
Wilms Tumour ◽  
Rhabdoid Tumour ◽  
Contrast Enhanced Ct ◽  
Contrast Enhanced ◽  
Renal Tumours ◽  
Enhanced Ct ◽  
Mr Characteristics

Eighteen children aged 6 months to 12 years with 20 solid renal tumours; 13 Wilms' tumours (WT), 2 clear cell sarcomas of the kidney, 1 malignant rhabdoid tumour of the kidney and 2 cases of bilateral nephroblastomatosis with Wilms' tumour underwent evaluation with US, CT and MR imaging. Contrast-enhanced CT and non-enhanced MR were equally accurate in determining the size and origin of the tumour but were unreliable in separation of stages I, II and III. US could only accurately assess the size of the tumours. MR characteristics varied somewhat between WTs and non-WTs but contrast-enhanced MR imaging might be useful for separation of WTs from nephroblastomatosis.

scholarly journals Immunohistochemical expression of p53 oncoprotein in Wilms tumour in relation to histological components, histological types and preoperative chemotherapy

2008 ◽  
Vol 136 (Suppl. 4) ◽  
pp. 298-306 ◽  
Author(s):  
Slavisa Djuricic ◽  
Dragomir Djokic ◽  
Dragana Vujic ◽  
Gordana Basta-Jovanovic ◽  
Vera Todorovic ◽  
...  
Keyword(s):  
Preoperative Chemotherapy ◽  
Nuclear Staining ◽  
Immunohistochemical Detection ◽  
Wilms Tumour ◽  
Immunohistochemical Expression ◽  
Single Institution ◽  
Histological Types ◽  
Renal Tumours ◽  
Stromal Component

INTRODUCTION. There have been only few studies of immunoexpression of p53 in Wilms tumour (WT), and their results are somewhat contradictory. OBJECTIVE. The aim of the study was to determine p53 immunohistochemical expression in WT in relation to its histological components, histological prognostic types classified according to the SIOP Working Classification of Renal Tumours of Childhood (2001), and influence of preoperative chemotherapy. METHOD. The analyses are based on 79 primary WTs treated in single institution according to SIOP protocols between 1983-2001. For the immunohistochemical detection of p53, the monoclonal p53 antibody (DO-7, DAKO) was used. Semiquantitative grading of nuclear staining was done. RESULTS. The immunoexpression of p53 was significantly higher in the blastemal and epithelial than in the stromal component (p<0.001). It was significantly correlated to WT histological prognostic types (p=0.039). The exensivity of p53 immunoexpression was higher in anaplastic components but a difference between WT type of diffuse anaplasia and all other types was nonsignificant (p=0.10). Five blastemal type WTs were p53 immunopositive and four immunonegative. There was no difference in p53 immunopositivity between WT treated with the preoperative chemotherapy and primary resected WT (p=0.88). CONCLUSION. The immunoexpression of p53 in WT was significantly higher in the blastemal and epithelial than in the stromal component. It was in significant correlation with histological types of WT. The anaplastic component had noticeable but statistically not significantly higher p53 immunoexpression than non-anaplastic. The preoperative chemotherapy did not modify p53 immunoexpression of WT which had been found in other similar studies.

Renal Tumours other than Wilms' Tumour in the Paediatric Age Group

1983 ◽  
Vol 38 (03) ◽  
pp. 163-168
Author(s):  
I. Oesch ◽  
M. Bettex ◽  
A. Zimmermann
Keyword(s):  
Age Group ◽  
Wilms Tumour ◽  
Renal Tumours ◽  
Paediatric Age

scholarly journals Renal tumours of childhood: The last 100 years and where to from here

2008 ◽  
Vol 136 (Suppl. 2) ◽  
pp. 142-151
Author(s):  
Gordan Vujanic
Keyword(s):  
Molecular Biology ◽  
Response To Treatment ◽  
Wilms Tumour ◽  
Rhabdoid Tumour ◽  
Treatment Groups ◽  
Molecular Features ◽  
Appropriate Treatment ◽  
Renal Tumours ◽  
Multicentre Trials ◽  
Histopathological Studies

Renal tumours of childhood represent a fascinating group of tumours in which very significant discoveries have been made in the last 100 years, leading to better understanding of these not only tumours but also tumour in general. By studying a large series of renal tumours of childhood collected through international multicentre trials, their clinico-pathological features have been better recognised resulting in more appropriate treatment and better prognosis, numerous new tumour entities have been identified, and thank to new molecular biology studies and techniques, many tumour genes and genetic abnormalities which are important in tumorigenesis have been found. The most common renal tumour of childhood is Wilms? tumour, which is now regarded as the most treatable tumour in children with overall survival of 90%. New multicentre trials are focused on reduction of treatment in order to avoid longterm sequalae of treatment, but without jeopardising these excellent survival results. Histopathological studies are searching for subtypes of Wilms? tumour, which could be treated with milder therapy, and in a recently launched trial patients will be stratified in different treatment groups on the basis of molecular features of their tumours. Molecular biology studies have helped us recognising that some renal tumours are identical to tumours of other sites (such as cellular mesoblastic nephroma and infantile fibrosarcoma of soft tissue, renal and extra-renal rhabdoid tumour), as well as that some tumours of other sites may also occur in the kidney (primitive neuroectodermal tumour, desmoplastic small round cell tumour, synovial sarcoma). Finally, some new, kidney-specific entities have been recognised too (metanephric stromal tumour, metanephric adenofibroma, anaplastic sarcoma of the kidney). It is very likely that new advances in molecular biology will result in identification of features, which are going to be even more important in predicting tumour behaviour, response to treatment and prognosis.

scholarly journals Diagnostic utility of Wilms′ tumour-1 protein (WT-1) immunostaining in paediatric renal tumours

2016 ◽  
Vol 143 (7) ◽  
pp. 59 ◽  
Author(s):  
Kiran Mishra ◽  
Surbhi Goyal ◽  
Urvee Sarkar ◽  
Satendra Sharma ◽  
Anita Kumari
Keyword(s):  
Diagnostic Utility ◽  
Wilms Tumour ◽  
Renal Tumours

Renal tumours

2019 ◽  
pp. 383-388
Author(s):  
Lesley Rees ◽  
Nicholas J.A Webb ◽  
Detlef Bockenhauer ◽  
Marilynn G. Punaro
Keyword(s):  
Renal Tumour ◽  
Wilms Tumour ◽  
Renal Tumours

Wilms tumour is the commonest renal tumour, and may be associated with syndromes. Overall the prognosis is good, but that is not the case for the rarer renal tumours.

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