UV-Vis Spectrophotometrical and Analytical Methodology for the Determination of Singlet Oxygen in New Antibacterials Drugs

2016 ◽  
pp. 35-49
Keyword(s):  
Singlet Oxygen ◽  
Analytical Methodology

UV-Vis Spectrophotometrical and Analytical Methodology for the Determination of Singlet Oxygen in New Antibacterials Drugs

2007 ◽  
Vol 2 ◽  
pp. 117739010700200 ◽  
Author(s):  
Tamara Zoltan ◽  
Franklin Vargas ◽  
Carla Izzo
Keyword(s):  
Reactive Oxygen Species ◽  
Singlet Oxygen ◽  
Nalidixic Acid ◽  
Reactive Oxygen ◽  
Oxygen Species ◽  
Inexpensive Method ◽  
Analytical Methodology ◽  
First Time

We have determined and quantified spectrophotometrically the capacity of producing reactive oxygen species (ROS) as 1O2 during the photolysis with UV-A light of 5 new synthesized naphthyl ester derivates of well-known quinolone antibacterials (nalidixic acid (1), cinoxacin (2), norfloxacin (3), ciprofloxacin (4) and enoxacin (5)). The ability of the naphthyl ester derivatives (6-10) to generate singlet oxygen were detecting and for the first time quantified by the histidine assay, a sensitive, fast and inexpensive method. The following tendency of generation of singlet oxygen was observed: compounds 7 >10 > 6 > 8 > 9 >> parent drugs 1-5.

scholarly journals Application of Bar Adsorptive Microextraction for the Determination of Levels of Tricyclic Antidepressants in Urine Samples

Molecules ◽  
2021 ◽  
Vol 26 (11) ◽  
pp. 3101
Author(s):  
Mariana N. Oliveira ◽  
Oriana C. Gonçalves ◽  
Samir M. Ahmad ◽  
Jaderson K. Schneider ◽  
Laiza C. Krause ◽  
...  
Keyword(s):  
Tricyclic Antidepressants ◽  
Matrix Effects ◽  
Activated Carbons ◽  
Process Efficiency ◽  
Gas Chromatography Mass Spectrometry ◽  
Selected Ion Monitoring ◽  
Experimental Conditions ◽  
Analytical Methodology ◽  
Low Efficiency

This work entailed the development, optimization, validation, and application of a novel analytical approach, using the bar adsorptive microextraction technique (BAμE), for the determination of the six most common tricyclic antidepressants (TCAs; amitriptyline, mianserin, trimipramine, imipramine, mirtazapine and dosulepin) in urine matrices. To achieve this goal, we employed, for the first time, new generation microextraction devices coated with convenient sorbent phases, polymers and novel activated carbons prepared from biomaterial waste, in combination with large-volume-injection gas chromatography-mass spectrometry operating in selected-ion monitoring mode (LVI-GC-MS(SIM)). Preliminary assays on sorbent coatings, showed that the polymeric phases present a much more effective performance, as the tested biosorbents exhibited low efficiency for application in microextraction techniques. By using BAμE coated with C18 polymer, under optimized experimental conditions, the detection limits achieved for the six TCAs ranged from 0.2 to 1.6 μg L−1 and, weighted linear regressions resulted in remarkable linearity (r2 > 0.9960) between 10.0 and 1000.0 μg L−1. The developed analytical methodology (BAμE(C18)/LVI-GC-MS(SIM)) provided suitable matrix effects (90.2–112.9%, RSD ≤ 13.9%), high recovery yields (92.3–111.5%, RSD ≤ 12.3%) and a remarkable overall process efficiency (ranging from 84.9% to 124.3%, RSD ≤ 13.9%). The developed and validated methodology was successfully applied for screening the six TCAs in real urine matrices. The proposed analytical methodology proved to be an eco-user-friendly approach to monitor trace levels of TCAs in complex urine matrices and an outstanding analytical alternative in comparison with other microextraction-based techniques.

Development and validation of an analytical methodology for the determination of p,p′-DDT, p,p′-DDE and p,p′-DDD in fish oil pills

2007 ◽  
Vol 86 (2) ◽  
pp. 183-188 ◽  
Author(s):  
Juan José Berzas Nevado ◽  
Rosa Carmen Rodríguez Martín-Doimeadiós ◽  
Francisco Javier Guzmán Bernardo ◽  
Nuria Rodríguez Fariñas
Keyword(s):  
Fish Oil ◽  
Analytical Methodology ◽  
Development And Validation

Determination of the quantum yield of singlet oxygen sensitized by halogenated boron difluoride dipyrromethenes

2017 ◽  
Vol 51 (3) ◽  
pp. 175-181 ◽  
Author(s):  
R. T. Kuznetsova ◽  
Iu. V. Aksenova ◽  
D. E. Bashkirtsev ◽  
A. S. Shulev ◽  
E. V. Antina ◽  
...  
Keyword(s):  
Quantum Yield ◽  
Singlet Oxygen ◽  
Boron Difluoride

Fast Analytical Methodology Based on Mass Spectrometry for the Determination of Volatile Biomarkers in Saliva

2011 ◽  
Vol 84 (1) ◽  
pp. 379-385 ◽  
Author(s):  
Miguel del Nogal Sánchez ◽  
Elena Hernández García ◽  
José Luis Pérez Pavón ◽  
Bernardo Moreno Cordero
Keyword(s):  
Mass Spectrometry ◽  
Analytical Methodology ◽  
Volatile Biomarkers

scholarly journals Determination of Spiroxamine Residues in Grapes, Must, and Wine by Gas Chromatography/Ion Trap-Mass Spectrometry

2005 ◽  
Vol 88 (6) ◽  
pp. 1834-1839 ◽  
Author(s):  
Nicholas G Tsiropoulos ◽  
Konstantinos Liapis ◽  
Dimitrios T Likas ◽  
George E Miliadis
Keyword(s):  
Mass Spectrometry ◽  
Gas Chromatography ◽  
Ion Trap ◽  
Extraction Procedure ◽  
Ion Trap Mass Spectrometry ◽  
Limit Of Quantification ◽  
Analytical Methodology ◽  
White Wines ◽  
Relative Standard

Abstract Analytical methodology was developed and validated for the determination of spiroxamine residues in grapes, must, and wine by gas chromatography/ion trap-mass spectrometry (GC/IT-MS). Two extraction procedures were used: the first involved grapes, must, and wine extraction with alkaline cyclohexane–dichloromethane (9 + 1, v/v) solution, and the second grape extraction with acetone, dichloromethane, and petroleum ether. In both procedures, the extract was centrifuged, evaporated to dryness, and reconstituted in cyclohexane or 2,2,4-trimethylpentane–toluene (9 + 1, v/v), respectively. Spiroxamine diastereomers A and B were determined by GC/IT-MS, and a matrix effect was observed in the case of grapes but not in must and wine. Recovery of spiroxamine from fortified samples at 0.02 to 5.0 mg/kg ranged from 78–102% for grapes and must, with relative standard deviation (RSD) <13%; for red and white wines, recoveries ranged from 90 to 101% with RSD <9%. The limit of quantification was 0.02 mg/kg for grapes, must, and wine or 0.10 mg/kg for grapes, depending on the extraction procedure used.

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