Combating Infectious Diseases: Nanotechnology-based Drug Delivery

2012 ◽  
pp. 121-150
Keyword(s):  
Drug Delivery ◽  
Infectious Diseases

scholarly journals Emerging skin-targeted drug delivery strategies to engineer immunity: A focus on infectious diseases

2020 ◽  
pp. 1-17
Author(s):  
Emrullah Korkmaz ◽  
Stephen C. Balmert ◽  
Cara Donahue Carey ◽  
Geza Erdos ◽  
Louis D. Falo
Keyword(s):  
Drug Delivery ◽  
Infectious Diseases ◽  
Targeted Drug Delivery ◽  
Delivery Strategies ◽  
Targeted Drug

scholarly journals Application of Dendrimers for the Treatment of Infectious Diseases

Molecules ◽  
2018 ◽  
Vol 23 (9) ◽  
pp. 2205 ◽  
Author(s):  
Zandile Mhlwatika ◽  
Blessing Aderibigbe
Keyword(s):  
Drug Delivery ◽  
Drug Resistance ◽  
Infectious Diseases ◽  
Water Solubility ◽  
Three Dimensional ◽  
Parasitic Infections ◽  
Release Mechanism ◽  
Macromolecular Network ◽  
And Control ◽  
Drug Encapsulation Efficiency

Dendrimers are drug delivery systems that are characterized by a three-dimensional, star-shaped, branched macromolecular network. They possess ideal properties such as low polydispersity index, biocompatibility and good water solubility. They are made up of the interior and the exterior layers. The exterior layer consists of functional groups that are useful for conjugation of drugs and targeting moieties. The interior layer exhibits improved drug encapsulation efficiency, reduced drug toxicity, and controlled release mechanisms. These unique properties make them useful for drug delivery. Dendrimers have attracted considerable attention as drug delivery system for the treatment of infectious diseases. The treatment of infectious diseases is hampered severely by drug resistance. Several properties of dendrimers such as their ability to overcome drug resistance, toxicity and control the release mechanism of the encapsulated drugs make them ideal systems for the treatment of infectious disease. The aim of this review is to discuss the potentials of dendrimers for the treatment of viral and parasitic infections.

scholarly journals Highlights in Mesoporous Silica Nanoparticles as a Multifunctional Controlled Drug Delivery Nanoplatform for Infectious Diseases Treatment

2020 ◽  
Vol 37 (10) ◽  
Author(s):  
Gabriela Corrêa Carvalho ◽  
Rafael Miguel Sábio ◽  
Tais de Cássia Ribeiro ◽  
Andreia Sofia Monteiro ◽  
Daniela Vassalo Pereira ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Mesoporous Silica ◽  
Infectious Diseases ◽  
Silica Nanoparticles ◽  
Mesoporous Silica Nanoparticles ◽  
Controlled Drug Delivery

scholarly journals Recent trends on hydrogel based drug delivery systems for infectious diseases

2016 ◽  
Vol 4 (11) ◽  
pp. 1535-1553 ◽  
Author(s):  
Arti Vashist ◽  
Ajeet Kaushik ◽  
Atul Vashist ◽  
Rahul Dev Jayant ◽  
Asahi Tomitaka ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Infectious Diseases ◽  
Targeted Drug Delivery ◽  
Drug Delivery Systems ◽  
Therapeutic Agents ◽  
Delivery Systems ◽  
Recent Trends ◽  
Targeted Drug ◽  
Targeted Drug Delivery Systems

Hydrogel based drug delivery systems owe excellent potential as targeted drug delivery systems for the delivery of therapeutic agents and diagnostics for major infectious diseases.

scholarly journals Drug Delivery Systems for Infectious Diseases

Drug Delivery ◽  
2017 ◽  
pp. 349-372
Author(s):  
Maximiliano L. Cacicedo ◽  
Germán A. Islan ◽  
Pablo Gurman ◽  
Guillermo R. Castro
Keyword(s):  
Drug Delivery ◽  
Infectious Diseases ◽  
Drug Delivery Systems ◽  
Delivery Systems

Topical Drug Delivery of Anti-infectives Employing Lipid-Based Nanocarriers: Dermatokinetics as an Important Tool

2019 ◽  
Vol 24 (43) ◽  
pp. 5108-5128 ◽  
Author(s):  
Kanika Thakur ◽  
Gajanand Sharma ◽  
Bhupindar Singh ◽  
Om Prakash Katare
Keyword(s):  
Drug Delivery ◽  
Infectious Diseases ◽  
Patient Compliance ◽  
Skin Permeation ◽  
Skin Penetration ◽  
Topical Delivery ◽  
Controlled Drug Release ◽  
Topical Drug Delivery ◽  
Promising Strategy ◽  
Drug Resistant Strains

Background:The therapeutic approaches for the management of topical infections have always been a difficult approach due to lack of efficacy of conventional topical formulations, high frequency of topical applications and non-patient compliance. The major challenge in the management of topical infections lies in antibiotic resistance which leads to severe complications and hospitalizations resulting in economic burden and high mortality rates.Methods:Topical delivery employing lipid-based carriers has been a promising strategy to overcome the challenges of poor skin permeation and retention along with large doses which need to be administered systemically. The use of lipid-based delivery systems is a promising strategy for the effective topical delivery of antibiotics and overcoming drug-resistant strains in the skin. The major systems include transfersomes, niosomes, ethosomes, solid lipid nanoparticles, nanostructured lipid carriers, microemulsion and nanoemulsion as the most promising drug delivery approaches to treat infectious disorders. The main advantages of these systems include lipid bilayer structure which mimics the cell membrane and can fuse with infectious microbes. The numerous advantages associated with nanocarriers like enhanced efficacy, improvement in bioavailability, controlled drug release and ability to target the desired infectious pathogen have made these carriers successful.Conclusion:Despite the number of strides taken in the field of topical drug delivery in infectious diseases, it still requires extensive research efforts to have a better perspective of the factors that influence drug permeation along with the mechanism of action with regard to skin penetration and deposition. The final objective of the therapy is to provide a safe and effective therapeutic approach for the management of infectious diseases affecting topical sites leading to enhanced therapeutic efficacy and patient-compliance.

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