Multiscale Simulation of Nanoparticle Transport in Deformable Tissue during an Infusion Process in Hyperthermia Treatments of Cancers

2012 ◽  
pp. 69-96
Author(s):  
Ronghui Ma ◽  
Di Su ◽  
Liang Zhu
Keyword(s):  
Multiscale Simulation ◽  
Nanoparticle Transport

scholarly journals Downscaled Finite Element Modeling of Metal Targets for Surface Roughness Level under Pulsed Laser Irradiation

2021 ◽  
Vol 11 (3) ◽  
pp. 1253
Author(s):  
Evaggelos Kaselouris ◽  
Kyriaki Kosma ◽  
Yannis Orphanos ◽  
Alexandros Skoulakis ◽  
Ioannis Fitilis ◽  
...  
Keyword(s):  
Surface Roughness ◽  
Finite Element ◽  
Surface Acoustic Waves ◽  
Pulsed Laser ◽  
Multiscale Simulation ◽  
Experimental Methodology ◽  
Computational Domain ◽  
Area Of Interest ◽  
Depth Analysis ◽  
Laser Solid Interactions

A three-dimensional, thermal-structural finite element model, originally developed for the study of laser–solid interactions and the generation and propagation of surface acoustic waves in the macroscopic level, was downscaled for the investigation of the surface roughness influence on pulsed laser–solid interactions. The dimensions of the computational domain were reduced to include the laser-heated area of interest. The initially flat surface was progressively downscaled to model the spatial roughness profile characteristics with increasing geometrical accuracy. Since we focused on the plastic and melting regimes, where structural changes occur in the submicrometer scale, the proposed downscaling approach allowed for their accurate positioning. Additionally, the multiscale simulation results were discussed in relation to experimental findings based on white light interferometry. The combination of this multiscale modeling approach with the experimental methodology presented in this study provides a multilevel scientific tool for an in-depth analysis of the influence of heat parameters on the surface roughness of solid materials and can be further extended to various laser–solid interaction applications.

scholarly journals Streamline-based simulation of nanoparticle transport in field-scale heterogeneous subsurface systems

2021 ◽  
Vol 148 ◽  
pp. 103842
Author(s):  
Bin Wang ◽  
Yin Feng ◽  
John Blears ◽  
Karsten Thompson ◽  
Richard Hughes
Keyword(s):  
Field Scale ◽  
Nanoparticle Transport

scholarly journals Nonlinear multiscale simulation of instabilities due to growth of an elastic film on a microstructured substrate

2020 ◽  
Vol 90 (11) ◽  
pp. 2397-2412
Author(s):  
Iman Valizadeh ◽  
Oliver Weeger
Keyword(s):  
Deformation Gradient ◽  
Multiscale Simulation ◽  
Numerical Results ◽  
Unit Cell ◽  
Homogeneous Material ◽  
Two Phase ◽  
Biological Phenomena ◽  
Elastic Film ◽  
Living Tissues ◽  
Analytical Approaches

Abstract The objective of this contribution is the numerical investigation of growth-induced instabilities of an elastic film on a microstructured soft substrate. A nonlinear multiscale simulation framework is developed based on the FE2 method, and numerical results are compared against simplified analytical approaches, which are also derived. Living tissues like brain, skin, and airways are often bilayered structures, consisting of a growing film on a substrate. Their modeling is of particular interest in understanding biological phenomena such as brain development and dysfunction. While in similar studies the substrate is assumed as a homogeneous material, this contribution considers the heterogeneity of the substrate and studies the effect of microstructure on the instabilities of a growing film. The computational approach is based on the mechanical modeling of finite deformation growth using a multiplicative decomposition of the deformation gradient into elastic and growth parts. Within the nonlinear, concurrent multiscale finite element framework, on the macroscale a nonlinear eigenvalue analysis is utilized to capture the occurrence of instabilities and corresponding folding patterns. The microstructure of the substrate is considered within the large deformation regime, and various unit cell topologies and parameters are studied to investigate the influence of the microstructure of the substrate on the macroscopic instabilities. Furthermore, an analytical approach is developed based on Airy’s stress function and Hashin–Shtrikman bounds. The wavelengths and critical growth factors from the analytical solution are compared with numerical results. In addition, the folding patterns are examined for two-phase microstructures and the influence of the parameters of the unit cell on the folding pattern is studied.

Multiscale simulation of nanostructures based on spatial secant model: a discrete hyperelastic approach

2008 ◽  
Vol 42 (4) ◽  
pp. 557-567 ◽  
Author(s):  
Dong Qian ◽  
Qingjin Zheng ◽  
Rodney S. Ruoff
Keyword(s):  
Multiscale Simulation

Multiscale simulation of a power-cooling system

2017 ◽  
Author(s):  
Daniele Cerroni ◽  
Roberto Da Vià ◽  
Sandro Manservisi ◽  
Filippo Menghini
Keyword(s):  
Cooling System ◽  
Multiscale Simulation
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